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  • 盐酸毛果芸香碱

    Pilocarpine Hydrochloride

    盐酸毛果芸香碱
    产品编号 CFN93245
    CAS编号 54-71-7
    分子式 = 分子量 C11H17ClN2O2 = 244.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Pilocarpus microphyllus (Jaborandi).
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    盐酸毛果芸香碱 CFN93245 54-71-7 10mg QQ客服:2056216494
    盐酸毛果芸香碱 CFN93245 54-71-7 20mg QQ客服:2056216494
    盐酸毛果芸香碱 CFN93245 54-71-7 50mg QQ客服:2056216494
    盐酸毛果芸香碱 CFN93245 54-71-7 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Research Council of Canada (Canada)
  • Medical University of Gdansk (Poland)
  • University of the Basque Country (Spain)
  • Chinese University of Hong Kong (China)
  • Indian Institute of Science (India)
  • Celltrion Chemical Research Institute (Korea)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidade de Franca (Brazil)
  • Shanghai University of TCM (China)
  • University of Brasilia (Brazil)
  • University of Eastern Finland (Finland)
  • Chulalongkorn University (Thailand)
  • University of Wollongong (Australia)
  • VIT University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(6):466.
  • Environ Toxicol.2023, 38(5):1174-1184.
  • Environ Toxicol.2022, 37(3):514-526.
  • Phytomedicine.2019, 67:153159
  • Foods.2023, 12(6):1227.
  • Int J Mol Sci.2019, 20(21):E5488
  • Anticancer Res.2024, 44(3):1033-1044.
  • VNU Journal of Science2023, No. 20.
  • Antioxidants (Basel).2020, 9(4):284.
  • Molecules.2023, 28(8):3503.
  • Int J Mol Sci.2021, 22(16):8641.
  • Front Pharmacol.2020, 11:683.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Phytomedicine.2016, 23(4):331-9
  • Environ Toxicol.2019, 34(4):513-520.
  • Chemistry of Natural Compounds2018, 204-206
  • Int. J. of Food Properties2017, S108-S118
  • Pak J Pharm Sci.2023, 36(1):51-57.
  • Int J Mol Sci.2021, 22(2):770.
  • Phytomedicine.2015, 22(4):498-503
  • Sci Rep.2015, 5:13194
  • Korean J. Medicinal Crop Sci.2023, 31(6):388-395.
  • Cells.2023, 12(3):395.
  • ...
  • 生物活性
    Description: Pilocarpine hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome. It has acaricidal activity.
    In vitro:
    Rev Bras Parasitol Vet. 2016 Jun 7;25(2):248-53.
    In vitro effects of Pilocarpus microphyllus extracts and pilocarpine hydrochloride on Rhipicephalus (Boophilus) microplus.[Pubmed: 27334829 ]
    The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and Pilocarpine Hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus.
    METHODS AND RESULTS:
    High performance liquid chromatography (HPLC) was performed to quantify these compounds. Larval packet and adult immersion tests were conducted with different concentrations. Five AE and EE concentrations, ranging from 6.2 to 100.0 mg mL-1, and six concentrations of Pilocarpine Hydrochloride, ranging from 0.7 to 24.0 mg mL-1, were tested. The lethal concentration (LC50) of each extract for larvae and engorged females was calculated through Probit analysis. The concentration of Pilocarpine Hydrochloride obtained from the EE and the AE was 1.3 and 0.3% (m/m), respectively. Pilocarpine Hydrochloride presented the highest acaricidal activity on larvae (LC50 2.6 mg mL-1) and engorged females (LC50 11.8 mg mL-1) of R.(B.) microplus, followed by the EE which presented LC50 of 56.4 and 15.9 mg mL-1, for larvae and engorged females, respectively.
    CONCLUSIONS:
    Such results indicate that Pilocarpine Hydrochloride has acaricidal activity, and may be the primary compound responsible for this activity by P. microphyllus EE.
    In vivo:
    Journal of Japanese Society of Oral Medicine,2009,15(1):1-8.
    Effect of Pilocarpine Hydrochloride Against Dry Mouth Associated with Sjogren's Syndrome.[Reference: WebLink]

    METHODS AND RESULTS:
    To evaluate the effect of Pilocarpine Hydrochloride for the treatment of dry mouth in patients with Sjögren's syndrome, 37 patients received 5 mg of Pilocarpine Hydrochloride three times daily, once after each meal, for 12 weeks. The increase in the saliva secretional capacity, the subjective and objective assessment of mouth dryness, and the subjective assessment of mouth dryness using a visual analogue scale;(VAS) were evaluated in this study. An improvement in all the subjects was observed beginning 4 weeks after the administration of Pilocarpine Hydrochloride. Twelve patients stopped taking pilocarpine because of adverse effects, mainly excessive sweating and nausea. However, no severe adverse effects occurred among the patients who continued treatment.
    CONCLUSIONS:
    Thus, Pilocarpine Hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0865 mL 20.4323 mL 40.8647 mL 81.7294 mL 102.1617 mL
    5 mM 0.8173 mL 4.0865 mL 8.1729 mL 16.3459 mL 20.4323 mL
    10 mM 0.4086 mL 2.0432 mL 4.0865 mL 8.1729 mL 10.2162 mL
    50 mM 0.0817 mL 0.4086 mL 0.8173 mL 1.6346 mL 2.0432 mL
    100 mM 0.0409 mL 0.2043 mL 0.4086 mL 0.8173 mL 1.0216 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    泽兰黄酮-7-O-葡萄糖苷; Nepetin 7-O-beta-D-glucopyranoside CFN91514 1627598-00-8 C22H24O12 = 480.4 5mg QQ客服:2159513211
    大豆皂苷Ab; Soyasaponin Ab CFN90773 118194-13-1 C67H104O33 = 1437.6 5mg QQ客服:2159513211
    Taxcultine; Taxcultine CFN96640 153415-46-4 C44H53NO14 = 819.90 5mg QQ客服:2056216494
    黄独素D; Diosbulbin D CFN97140 66756-57-8 C19H20O6 = 344.4 5mg QQ客服:2056216494

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