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  • 商陆皂苷元

    Phytolaccagenin

    商陆皂苷元
    产品编号 CFN99844
    CAS编号 1802-12-6
    分子式 = 分子量 C31H48O7 = 532.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Phytolacca acinosa Roxb
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    商陆皂苷元 CFN99844 1802-12-6 10mg QQ客服:1413575084
    商陆皂苷元 CFN99844 1802-12-6 20mg QQ客服:1413575084
    商陆皂苷元 CFN99844 1802-12-6 50mg QQ客服:1413575084
    商陆皂苷元 CFN99844 1802-12-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Center for protein Engineering (CIP) (Belgium)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Kyoto University (Japan)
  • Uniwersytet Gdański (Poland)
  • The Institute of Cancer Research (United Kingdom)
  • University of Stirling (United Kingdom)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Helsinki (Finland)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Gyeongsang National University (Korea)
  • University of Mysore (India)
  • University of Otago (New Zealand)
  • Monash University Malaysia (Malaysia)
  • University of Cincinnati (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(7):1625.
  • Nutr Res Pract2019, 13:e45
  • Toxicol In Vitro.2022, 81:105346.
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Phytochemistry.2021, 181:112539.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Molecules2021, 26(1),230
  • Phytother Res.2019, 33(4):1104-1113
  • Molecules.2020, 25(18):4283.
  • Molecules.2022, 27(22):7997.
  • Food Chemistry: X2023, 101032.
  • Institute of Food Science & Technology2021, 56(11).
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Molecules.2020, 25(21):5087.
  • Braz J Med Biol Res. 2016, 49(7)
  • Food Chem.2019, 274:345-350
  • Phytother Res.2020, 34(4):788-795.
  • Int J Biol Macromol.2019, 126:653-661
  • Food Bioscience2022, 50:102187.
  • Natural Product Communications2020, doi: 10.1177.
  • Wageningen University & Research2018, January 2018
  • Plants (Basel).2021, 10(4):702.
  • Int J Mol Sci.2022, 23(11):6104.
  • ...
  • 生物活性
    Description: Phytolaccagenin has promising antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi, it also shows inhibitory effects on lipopolysaccharide-induced NO production, and haemolytic activities.
    Targets: Antifection | NO
    In vitro:
    Nat. Prod. Commun.,2010, 5(7):1013-8.
    Antifungal activity of saponin-rich extracts of Phytolacca dioica and of the sapogenins obtained through hydrolysis.[Pubmed: 20734930]

    METHODS AND RESULTS:
    A saponin-rich extract of Phytolacca dioica L. berries, its acid hydrolysate, and its major aglycone, phytolaccagenin, were assayed for antifungal activity against ATCC standard cultures of Candida albicans and Cryptococcus neoformans, and against clinical isolates of these fungi. The activity of the extract was either low or negligible, but the hydrolysate, containing the sapogenins, including phytolaccagenin, and also pure phytolaccagenin, showed promising antifungal potency.
    CONCLUSIONS:
    Hydrolysis of a natural product extract is shown to be a useful modification leading to improved bioactivity.
    In vivo:
    J Pharm Biomed Anal . 2015 Mar 25;107:82-8.
    Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study[Pubmed: 25575173]
    Abstract Radix Phytolaccae (the dried root of Phytolacca acinosa Roxb. or Phytolacca americana L.) is widely used in East Asian countries for the treatment of inflammation-related diseases. The active component of Radix Phtolaccae is Phytolcaccagenin a triterpenoid saponin. Phytolcaccagenin has anti-inflammatory activities that exceed those of Esculentoside A and its derivatives regarding suppression of LPS-induced inflammation, and has a lower toxicity profile with less hemolysis. To date, no information is available about analytical method and pharmacokinetic studies of phytolaccagenin. To explore PK profile of this compound, a HPLC-MS/MS assay of phytolaccagenin in rat plasma was developed and validated. The method was fully validated according to FDA Guidance for industry. The detection was performed by a triple-quadrupole tandem mass spectrometer with multiple reactions monitoring (MRM) in positive ion mode via electrospray ionization. The monitored transitions were m/z 533.2>515.3 for Phytolcaccagenin, and 491.2>473.2 for I.S. The analysis was performed on a Symmetry C18 column (4.6 mm × 50 mm, 3.5 μm) using gradient elution with the mobile phase consisting of acetonitrile and 0.1% formic acid water at a flow rate of 1 ml/min with a 1:1 splitter ratio. The method was validated with a LLOQ of 20 ng/ml and an ULOQ of 1000 ng/ml. The response versus concentration data were fitted with 1/x weighting and the correlation coefficient (r) were greater than 0.999. The average matrix effect and the average extraction recovery were acceptable. This validation in rat plasma demonstrated that phytolaccagenin was stable for 30 days when stored below -20°C, for 6h at room temperature (RT, 22°C), for 12 h at RT for prepared control samples in auto-sampler vials, and during three successive freeze/thaw cycles results at -20°C. The validated method has been successfully applied to an intravenous bolus pharmacokinetic study of phytolaccagenin in male Sprague-Dawley rats (10 mg/kg, i.v.). Blood samples taken from 0 to 24h after injection were collected, and data analyzed with WinNonlin. The half-life and clearance were 1.4±0.9 h and 2.1±1.1 L/h/kg, respectively. Keywords: Anti-inflammatory; HPLC–MS/MS; Pharmacokinetic study; Phytolaccagenin; Validation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8772 mL 9.3861 mL 18.7723 mL 37.5446 mL 46.9307 mL
    5 mM 0.3754 mL 1.8772 mL 3.7545 mL 7.5089 mL 9.3861 mL
    10 mM 0.1877 mL 0.9386 mL 1.8772 mL 3.7545 mL 4.6931 mL
    50 mM 0.0375 mL 0.1877 mL 0.3754 mL 0.7509 mL 0.9386 mL
    100 mM 0.0188 mL 0.0939 mL 0.1877 mL 0.3754 mL 0.4693 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-beta-O-顺式-对-香豆酰马期里酸; 3-beta-O-(cis-p-Coumaroyl)maslinic acid CFN92208 69297-40-1 C39H54O6 = 618.9 5mg QQ客服:215959384
    Eucalyptolic acid; Eucalyptolic acid CFN92275 189272-68-2 C40H56O7 = 648.9 5mg QQ客服:1457312923
    脱氢山楂酸; Camaldulenic acid CFN96017 71850-15-2 C30H46O4 = 470.7 5mg QQ客服:2056216494
    阿江榄仁酸; Arjunic acid CFN98397 31298-06-3 C30H48O5 = 488.7 5mg QQ客服:215959384
    阿江榄仁酸; Arjunolic acid CFN98690 465-00-9 C30H48O5 = 488.7 5mg QQ客服:2056216494
    阿江榄仁素; Arjungenin CFN95039 58880-25-4 C30H48O6 = 504.7 20mg QQ客服:215959384
    3-O-香豆酰阿江榄仁酸; 3-O-Coumaroylarjunolic acid CFN96829 171864-20-3 C39H54O7 = 634.85 5mg QQ客服:2056216494
    2,3-二羟基-12-齐墩果烯-28-酸; 2,3-Dihydroxy-12-oleanen-28-oic acid CFN98310 26563-68-8 C30H48O4 = 472.7 5mg QQ客服:1457312923
    2,3,23-三羟基-12-齐墩果烯-28-酸; 2,3,23-Trihydroxy-12-oleanen-28-oic acid CFN99041 102519-34-6 C30H48O5 = 488.7 5mg QQ客服:3257982914
    2alpha,3alpha,24-三羟基-12-烯-28-齐墩果酸; 2,3,24-Trihydroxyolean-12-en-28-oic acid CFN99628 150821-16-2 C30H48O5 = 488.7 5mg QQ客服:2159513211

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