远志皂苷元

Senegenin

	产品编号	CFN99109
	CAS编号	2469-34-3
	分子式 = 分子量	C₃₀H₄₅ClO₆ = 537.14
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The roots of Polygala tenuifolia Willd.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
远志皂苷元	CFN99109	2469-34-3	10mg	QQ客服：3257982914
远志皂苷元	CFN99109	2469-34-3	20mg	QQ客服：3257982914
远志皂苷元	CFN99109	2469-34-3	50mg	QQ客服：3257982914
远志皂苷元	CFN99109	2469-34-3	100mg	QQ客服：3257982914

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Senegenin has anti-apoptotic,anti-oxidative,and neuroprotective activities, it might be a potential agent for prevention and treatment of postoperative cognitive dysfunction (POCD) or other neurodegenerative diseases. It also be a potential therapeutic agent against sepsis. Senegenin decreased the levels of TNF-α ,IL-1β, NF-κB.

Targets:

TNF-α | IL Receptor | NF-kB | JNK

In vitro:

Zhong Yao Cai. 2013 Sep;36(9):1477-80.

Neurotrophic effects of senegenin.[Pubmed: 24620696]

To study the neurotrophic effects of senegenin on the expression of MAP2 mRNA and BDNF mRNA in cultured cerebral cortical neurons.
METHODS AND RESULTS:
The newborn rat cerebral cortex neurons were cultured in vitro. LDH assay was used to investigate the effect of senegenin on the neuronal viability and reverse transcription polymerase chain reaction (RT-PCR) was carried out to determine the expression level of MAP2 mRNA and BDNF mRNA. LDH assay showed that senegenin at the concentration of 0. 5 micromol/L,1 micromol/L and 2 micromol/L could obviously enhance the survival of cells and the survival rates were in dose-dependent manner to some extent. Moreover, the low, medium and high concentrations of senegenin significantly increased the expression of MAP2 mRNA and BDNF mRNA.
CONCLUSIONS:
The study suggests that suitable dose of senegenin can increase the expression of MAP2 mRNA and BDNF mRNA in cultured cerebral cortical neurons, and its mechanism needs further study.

In vivo:

Inflammation. 2016 Apr;39(2):900-6.

Senegenin Ameliorate Acute Lung Injury Through Reduction of Oxidative Stress and Inhibition of Inflammation in Cecal Ligation and Puncture-Induced Sepsis Rats.[Pubmed: 26945584 ]

The purpose of this study was to assess the protective effect of senegenin on acute lung injury (ALI) in rats induced by sepsis.
METHODS AND RESULTS:
Rat ALI model was reproduced by cecal ligation and puncture (CLP). All rats were randomly divided into five groups: group 1 (control), group 2 (CLP), group 3 (CLP + senegenin 15 mg/kg), group 4 (CLP + senegenin 30 mg/kg), and group 5 (CLP + senegenin 60 mg/kg). CLP + senegenin groups received senegenin by gavage daily for consecutive 5 days, respectively, while the mice in control and CLP groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of lung tissue myeloperoxidase (MPO), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were determined. Meanwhile, the nuclear factor-kappa B (NF-κB) activation, tumor necrosis factor-alpha (TNF-α), and interleukin-1β (IL-1β) levels were studied. The results demonstrated that senegenin treatment significantly attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, protein leak, infiltration of leukocytes, and MPO activity. In addition, senegenin markedly decreased MDA content and increased SOD activity and GSH level. Serum levels of TNF-α and IL-1β were also decreased by senegenin administration. Furthermore, senegenin administration inhibited the nuclear translocation of NF-κB in the lungs.
CONCLUSIONS:
These findings indicate that senegenin exerts protective effects on CLP-induced septic rats. Senegenin may be a potential therapeutic agent against sepsis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2alpha,3alpha,24-三羟基-12-烯-28-齐墩果酸; 2,3,24-Trihydroxyolean-12-en-28-oic acid	CFN99628	150821-16-2	C₃₀H₄₈O₅ = 488.7	5mg	QQ客服：1457312923
贝萼皂苷元；贝萼甙元; Bayogenin	CFN90314	6989-24-8	C₃₀H₄₈O₅ = 488.70	20mg	QQ客服：215959384
贝萼皂苷元甲酯; Bayogenin methyl ester	CFN92819	22425-81-6	C₃₁H₅₀O₅ = 502.4	5mg	QQ客服：215959384
儿茶酚; Caulophyllogenin	CFN91135	52936-64-8	C₃₀H₄₈O₅ = 488.7	5mg	QQ客服：1413575084
远志酸; Polygalacic acid	CFN99108	22338-71-2	C₃₀H₄₈O₆ = 504.71	5mg	QQ客服：2056216494
桔梗皂苷元; Platycodigenin	CFN92207	22327-82-8	C₃₀H₄₈O₇ = 520.7	10mg	QQ客服：1457312923
美商陆酸; Phytolaccagenic acid	CFN91881	54928-05-1	C₃₁H₄₈O₆ = 516.71	5mg	QQ客服：3257982914
商陆皂苷元; Phytolaccagenin	CFN99844	1802-12-6	C₃₁H₄₈O₇ = 532.7	20mg	QQ客服：2056216494
远志酸; Polygalic acid	CFN92195	1260-04-4	C₂₉H₄₄O₆ = 488.7	20mg	QQ客服：1413575084
苜蓿酸; Medicagenic acid	CFN93933	599-07-5	C₃₀H₄₆O₆ = 502.68	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8617 mL	9.3086 mL	18.6171 mL	37.2342 mL	46.5428 mL
5 mM	0.3723 mL	1.8617 mL	3.7234 mL	7.4468 mL	9.3086 mL
10 mM	0.1862 mL	0.9309 mL	1.8617 mL	3.7234 mL	4.6543 mL
50 mM	0.0372 mL	0.1862 mL	0.3723 mL	0.7447 mL	0.9309 mL
100 mM	0.0186 mL	0.0931 mL	0.1862 mL	0.3723 mL	0.4654 mL

远志皂苷元

Senegenin

信息支持

联系方式