具栖冬青苷

Pedunculoside

	产品编号	CFN99701
	CAS编号	42719-32-4
	分子式 = 分子量	C₃₆H₅₈O₁₀ = 650.84
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The barks of Ilex rotunda Thunb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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具栖冬青苷	CFN99701	42719-32-4	10mg	QQ客服：215959384
具栖冬青苷	CFN99701	42719-32-4	20mg	QQ客服：215959384
具栖冬青苷	CFN99701	42719-32-4	50mg	QQ客服：215959384
具栖冬青苷	CFN99701	42719-32-4	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Perugia (Italy)

Sapienza University of Rome (Italy)

Uniwersytet Jagielloński w Krakowie (Poland)

Nanjing University of Chinese Medicine (China)

Weizmann Institute of Science (Israel)

Universidad de La Salle (Mexico)

University of Amsterdam (Netherlands)

The Institute of Cancer Research (United Kingdom)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Guangzhou Institutes of Biomedicine and Health (China)

University of Fribourg (Switzerland)

Macau University of Science and Technology (China)

University of Melbourne (Australia)

S.N.D.T. Women's University (India)

More...

Description:

Pedunculoside shows significant hypocholesterolemic and anti-inflammatory activities, it shows potential nitric oxide inhibitory activities with the IC50 value ranging from 14.92 uM to 52.23 uM.

Targets:

In vitro:

Planta Med. 2013 May;79(8):687-92.

Inhibitory activity of chemical constituents from Arenaria serpyllifolia on nitric oxide production.[Pubmed: 23670630]

Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-β-D-glucopyranoside (1), one new lignan, 3-(β-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new γ-pyrones, japonicumone A 4'-O-β-D-glucopyranoside (3), japonicumone B 3'-O-β-D-glucopyranoside (4), and japonicumone B 4'-O-β-D-glucopyranoside (5), together with eight known compounds (6-13) were isolated from the whole plants of Arenaria serpyllifolia.
METHODS AND RESULTS:
Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1-5, sacranoside A (9), and pedunculoside (13) showed potential nitric oxide inhibitory activities with IC50 values ranging from 14.92 µM to 52.23 µM.

In vivo:

Pharm. Biol.,1999, 37(1):37- 41.

Hypolipidemic Activity of Pedunculoside, A Constituent of Ilex doniana.[Reference: WebLink]

Pedunculoside, an ester glucoside of 3ß, 19a, 23-trihydroxyurs-12-en-28-oic acid, was isolated from the leaves of Ilex doniana DC. On dietary administration to hyperlipidemic albino rats, it showed significant hypocholesterolemic activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-O-反式对香豆酰委陵菜酸; 3-O-trans-p-Coumaroyltormentic acid	CFN97843	121064-78-6	C₃₉H₅₄O₇ = 634.86	5mg	QQ客服：2159513211
铁冬青酸; Rutundic acid	CFN98547	20137-37-5	C₃₀H₄₈O₅ = 488.71	20mg	QQ客服：3257982914
Rotundanonic acid; Rotundanonic acid	CFN96850	173357-19-2	C₃₀H₄₆O₅ = 486.69	5mg	QQ客服：215959384
具栖冬青苷; Pedunculoside	CFN99701	42719-32-4	C₃₆H₅₈O₁₀ = 650.84	20mg	QQ客服：1413575084
3,6,19,23-四羟基-12-熊果-28-酸; 3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid	CFN97476	91095-51-1	C₃₀H₄₈O₆ = 504.7	5mg	QQ客服：2056216494
3,6,19-三羟基-23-氧代-12-乌苏烯-28-酸; 3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid	CFN99403	131984-82-2	C₃₀H₄₆O₆ = 502.7	5mg	QQ客服：215959384
3,19-二羟基-6,23-二氧代-12-乌苏烯-28-酸; 3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid	CFN98299	261768-88-1	C₃₀H₄₄O₆ = 500.7	5mg	QQ客服：3257982914
毛冬青皂苷 A; Ilexsaponin A	CFN90995	108524-93-2	C₃₆H₅₆O₁₁ = 664.83	10mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5365 mL	7.6824 mL	15.3648 mL	30.7295 mL	38.4119 mL
5 mM	0.3073 mL	1.5365 mL	3.073 mL	6.1459 mL	7.6824 mL
10 mM	0.1536 mL	0.7682 mL	1.5365 mL	3.073 mL	3.8412 mL
50 mM	0.0307 mL	0.1536 mL	0.3073 mL	0.6146 mL	0.7682 mL
100 mM	0.0154 mL	0.0768 mL	0.1536 mL	0.3073 mL	0.3841 mL