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  • 毛冬青皂苷 A

    • 毛冬青皂苷 A

    Ilexsaponin A

    毛冬青皂苷 A
    		产品编号 CFN90995
    CAS编号 108524-93-2
    分子式 = 分子量 C36H56O11 = 664.83
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Ilex pubescens Hook. et Arn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毛冬青皂苷 A CFN90995 108524-93-2 1mg QQ客服：3257982914
    毛冬青皂苷 A CFN90995 108524-93-2 5mg QQ客服：3257982914
    毛冬青皂苷 A CFN90995 108524-93-2 10mg QQ客服：3257982914
    毛冬青皂苷 A CFN90995 108524-93-2 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Vienna (Austria)
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  • Universitas islam negeri Jakarta (Indonesia)
  • University of Eastern Finland (Finland)
  • Worcester Polytechnic Institute (USA)
  • Chulalongkorn University (Thailand)
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  • CSIRO - Agriculture Flagship (Australia)
  • University of Indonesia (Indonesia)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Fitoterapia.2024, 175:105958.
  • National Academy Science Letters2023, s40009.
  • Natural Product Communications2020, doi: 10.1177.
  • Nat Prod Sci.2014, 20(3):182-190
  • Biomed Pharmacother.2020, 131:110673.
  • LWT2020, 124:109163
  • Int J Mol Sci.2023, 24(23):17118.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Genes Genomics.2020, 10.1007
  • Food Research International2023, 113792.
  • Antioxidants (Basel).2020, 9(4):284.
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • Chem Biol Interact.2020, 328:109200.
  • Metabolites.2023, 13(5):625.
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • PLoS One.2022, 17(4):e0267007.
  • Sci Rep. 2018, 1-9
  • Front Pharmacol.2022, 13:919230.
  • Food Analytical Methods2017, 10:3225-3234
  • Anal Sci.2019, 35(12):1317-1325
  • Drug Chem Toxicol.2020, 1-12.
  • Hortic Res.2023, 10(4):uhad039.
  • Molecules.2023, 28(2):727.
  • ...
    • 生物活性
    Description: Ilexsaponin A shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
    Targets: Bcl-2/Bax | Caspase | Akt
    In vitro:
    PLoS One. 2017 Feb 9;12(2):e0170984.
    Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.[Pubmed: 28182689]
    The protective effects of Ilexsaponin A on ischemia-reperfusion-induced myocardial injury were investigated.
    METHODS AND RESULTS:
    Myocardial ischemia/reperfusion model was established in male Sprague-Dawley rats. Myocardial injury was evaluated by TTC staining and myocardial marker enzyme leakage. The in vitro protective potential of Ilexsaponin A was assessed on hypoxia/reoxygenation cellular model in neonatal rat cardiomyocytes. Cellular viability and apoptosis were evaluated by MTT and TUNEL assay. Caspase-3, cleaved caspase-3, bax, bcl-2, p-Akt and Akt protein expression levels were detected by western-blot. Ilexsaponin A treatment was able to attenuate the myocardial injury in ischemia/reperfusion model by reducing myocardial infarct size and lower the serum levels of LDH, AST and CK-MB. The in vitro study also showed that Ilexsaponin A treatment could increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes. Proapoptotic proteins including caspase-3, cleaved caspase-3 and bax were significantly reduced and anti-apoptotic protein bcl-2 was significantly increased by Ilexsaponin A treatment in hypoxia/reoxygenation cardiomyocytes. Moreover, Ilexsaponin A treatment was able to increase the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model.
    CONCLUSIONS:
    Coupled results from both in vivo and in vitro experiments indicate that Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5041 mL 7.5207 mL 15.0414 mL 30.0829 mL 37.6036 mL
    5 mM 0.3008 mL 1.5041 mL 3.0083 mL 6.0166 mL 7.5207 mL
    10 mM 0.1504 mL 0.7521 mL 1.5041 mL 3.0083 mL 3.7604 mL
    50 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6017 mL 0.7521 mL
    100 mM 0.015 mL 0.0752 mL 0.1504 mL 0.3008 mL 0.376 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-O-反式对香豆酰委陵菜酸; 3-O-trans-p-Coumaroyltormentic acid CFN97843 121064-78-6 C39H54O7 = 634.86 5mg QQ客服：2159513211
    铁冬青酸; Rutundic acid CFN98547 20137-37-5 C30H48O5 = 488.71 20mg QQ客服：1457312923
    Rotundanonic acid; Rotundanonic acid CFN96850 173357-19-2 C30H46O5 = 486.69 5mg QQ客服：1457312923
    具栖冬青苷; Pedunculoside CFN99701 42719-32-4 C36H58O10 = 650.84 20mg QQ客服：3257982914
    3,6,19,23-四羟基-12-熊果-28-酸; 3,6,19,23-Tetrahydroxy-12-ursen-28-oic acid CFN97476 91095-51-1 C30H48O6 = 504.7 5mg QQ客服：2056216494
    3,6,19-三羟基-23-氧代-12-乌苏烯-28-酸; 3,6,19-Trihydroxy-23-oxo-12-ursen-28-oic acid CFN99403 131984-82-2 C30H46O6 = 502.7 5mg QQ客服：1413575084
    3,19-二羟基-6,23-二氧代-12-乌苏烯-28-酸; 3,19-Dihydroxy-6,23-dioxo-12-ursen-28-oic acid CFN98299 261768-88-1 C30H44O6 = 500.7 5mg QQ客服：1413575084
    毛冬青皂苷 A; Ilexsaponin A CFN90995 108524-93-2 C36H56O11 = 664.83 10mg QQ客服：2159513211

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