| In vitro: |
| Nat Prod Commun. 2013 Aug;8(8):1115-6. | | A new nervogenic acid glycoside with pro-coagulant activity from Liparis nervosa.[Pubmed: 24079181] |
METHODS AND RESULTS:
In an effort to identify hemostatic components from Liparis nervosa (Thunb.) Lindl. using a bioactivity-guided fractionation approach, the n-BuOH extract was found to promote ADP-induced platelet aggregation and two compounds were isolated from the active extract.
METHODS AND RESULTS:
Compound 1 was a new Nervogenic acid glycoside and the structure was elucidated as 3,5-bis(3-methyl-but-2-enyl)-4-O-[beta-D-xylopyranosyl-(1 -->2)-beta-D-glucopyranosyl]-benzoic acid by extensive spectroscopic measurements.
Adenosine (2) was isolated from this plant for the first time. Compound 1 also showed good pro-coagulant activity in vitro. | | Planta Med. 2013 Mar;79(3-4):281-7. | | New nervogenic acid derivatives from Liparis nervosa.[Pubmed: 23322560] |
METHODS AND RESULTS:
Ten new Nervogenic acid derivatives (1-4, 6-11) and one known compound (5) have been isolated from Liparis nervosa. Their structures were determined using extensive spectroscopic analysis, including 1D and 2D NMR experiments.
CONCLUSIONS:
Compounds 3, 4, 9, 10, and 11 were evaluated for their cytotoxicity against A549, H460, Hela, MCF-7, Caco2, and HepG2 human cancer cell lines. | | Food Sci.Technol. Int.(Tokyo),1997, 3(3):285-9. | | Antioxidative Constituents from the Aerial Part of Piper elongatum VAHL.[Reference: WebLink] |
METHODS AND RESULTS:
Six aromatic compounds, asebogenin (1), 2',6'-dihydroxy-4'-methoxydihydrochalcone (2), 3-geranyl-4-methoxy-benzoic acid (3), 3-geranyl-4-hydroxybenzoic acid (4), Nervogenic acid (5) and 2,2-dimethyl-6-carboxyl-8-prenyl-chromene (6) were isolated from the methanol extract of the aerial part of Piper elongatum VAHL., whose leaves are used as a folk medicine in South America. The structures of 1-6 were elucidated by MS, 1H-NMR and 13C-NMR spectroscopies, and chemical evidence.
CONCLUSIONS:
Among these compounds, 1 showed stronger antioxidative activity than that of α-tocopherol, and 4 and 5 exhibited higher activity than that of t-butyl-4-hydroxyanisole (BHA) using the ferric thiocyanate method. |
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