环萜酚酸

Cannabichromenic acid

	产品编号	CFN91611
	CAS编号	185505-15-1
	分子式 = 分子量	C₂₂H₃₀O₄ = 358.47
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The herbs of Cannabis sativa.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
环萜酚酸	CFN91611	185505-15-1	1mg	QQ客服：3257982914
环萜酚酸	CFN91611	185505-15-1	5mg	QQ客服：3257982914
环萜酚酸	CFN91611	185505-15-1	10mg	QQ客服：3257982914
环萜酚酸	CFN91611	185505-15-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Cannabichromenic acid is a new antibiotic active against gram-positive bacteria, including MRSA.

In vitro:

Antibiotics (Basel) . 2020 Aug 16;9(8):523.

Rapid Antibacterial Activity of Cannabichromenic Acid against Methicillin-Resistant Staphylococcus aureus[Pubmed: 32824356]

Methicillin-resistant Staphylococcus aureus (MRSA) has proven to be an imminent threat to public health, intensifying the need for novel therapeutics. Previous evidence suggests that cannabinoids harbour potent antibacterial activity. In this study, a group of previously inaccessible phytocannabinoids and synthetic analogues were examined for potential antibacterial activity. The minimum inhibitory concentrations and dynamics of bacterial inhibition, determined through resazurin reduction and time-kill assays, revealed the potent antibacterial activity of the phytocannabinoids against gram-positive antibiotic-resistant bacterial species, including MRSA. One phytocannabinoid, cannabichromenic acid (CBCA), demonstrated faster and more potent bactericidal activity than vancomycin, the currently recommended antibiotic for the treatment of MRSA infections. Such bactericidal activity was sustained against low-and high-dose inoculums as well as exponential- and stationary-phase MRSA cells. Further, mammalian cell viability was maintained in the presence of CBCA. Finally, microscopic evaluation suggests that CBCA may function through the degradation of the bacterial lipid membrane and alteration of the bacterial nucleoid. The results of the current study provide encouraging evidence that cannabinoids may serve as a previously unrecognised resource for the generation of novel antibiotics active against MRSA.

In vivo:

J Nat Prod. 2019 Nov 22;82(11):3047-3055.

Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome[Pubmed: 31686510]

Cannabis sativa produces a complex mixture of many bioactive molecules including terpenophenolic compounds known as phytocannabinoids. Phytocannabinoids come in neutral forms (e.g., Δ9-tetrahydrocannabinol, THC; cannabidiol, CBD; etc.) or as acid precursors, which are dominant in the plant (e.g., Δ9-tetrahydrocannabinolic acid, THCA; cannabidiolic acid, CBDA; etc.). There is increasing interest in unlocking the therapeutic applications of the phytocannabinoid acids; however, the present understanding of the basic pharmacology of phytocannabinoid acids is limited. Herein the brain and plasma pharmacokinetic profiles of CBDA, THCA, cannabichromenic acid (CBCA), cannabidivarinic acid (CBDVA), cannabigerolic acid (CBGA), and cannabigerovarinic acid (CBGVA) were examined following intraperitoneal administration in mice. Next it was examined whether CBDA was anticonvulsant in a mouse model of Dravet syndrome (Scn1aRX/+ mice). All the phytocannabinoid acids investigated were rapidly absorbed with plasma tmax values of between 15 and 45 min and had relatively short half-lives (<4 h). The brain-plasma ratios for the acids were very low at ≤0.04. However, when CBDA was administered in an alternate Tween 80-based vehicle, it exhibited a brain-plasma ratio of 1.9. The anticonvulsant potential of CBDA was examined using this vehicle, and it was found that CBDA significantly increased the temperature threshold at which the Scn1aRX/+ mice had a generalized tonic-clonic seizure.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
大麻色原烯; Cannabichromene	CFN98039	20675-51-8	C₂₁H₃₀O₂ = 314.5	5mg	QQ客服：2056216494
次色酚酸; Cannabichromevarinic acid	CFN91609	64898-02-8	C₂₀H₂₆O₄ = 330.42	5mg	QQ客服：1413575084
环萜酚酸; Cannabichromenic acid	CFN91611	185505-15-1	C₂₂H₃₀O₄ = 358.47	5mg	QQ客服：1413575084
茅术色烯; Atractylochromene	CFN95162	203443-33-8	C₁₇H₂₂O₂ = 258.4	10mg	QQ客服：3257982914
Denudaquinol; Denudaquinol	CFN91935	1189105-40-5	C₁₉H₂₆O₄ = 318.41	5mg	QQ客服：2056216494
4-羟基-3,5-双(3-甲基-2-丁烯-1-基)苯甲酸; Nervogenic acid	CFN99828	17622-86-5	C₁₇H₂₂O₃ = 274.4	5mg	QQ客服：2056216494
4-羟基-3-(3-甲基-2-丁烯酰基)-5-(3-甲基-2-丁烯基)苯甲酸; 4-Hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)benzoic acid	CFN99652	155051-85-7	C₁₇H₂₀O₄ = 288.3	5mg	QQ客服：2159513211
2,2-二甲基-8-(3-甲基-2-丁烯基)-2H-苯并吡喃-6-羧酸; 2,2-Dimethyl-8-prenylchromene 6-carboxylic acid	CFN99633	151731-50-9	C₁₇H₂₀O₃ = 272.3	5mg	QQ客服：2056216494
次萜酚酸; Cannabigerovarinic acid	CFN91610	64924-07-8	C₂₀H₂₈O₄ = 332.43	5mg	QQ客服：2056216494
大麻萜酚; Cannabigerol	CFN98287	25654-31-3	C₂₁H₃₂O₂ = 316.5	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7896 mL	13.9482 mL	27.8963 mL	55.7927 mL	69.7408 mL
5 mM	0.5579 mL	2.7896 mL	5.5793 mL	11.1585 mL	13.9482 mL
10 mM	0.279 mL	1.3948 mL	2.7896 mL	5.5793 mL	6.9741 mL
50 mM	0.0558 mL	0.279 mL	0.5579 mL	1.1159 mL	1.3948 mL
100 mM	0.0279 mL	0.1395 mL	0.279 mL	0.5579 mL	0.6974 mL

环萜酚酸

Cannabichromenic acid

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