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  • 新橙皮苷


    产品编号 CFN99125
    CAS编号 13241-33-3
    分子式 = 分子量 C28H34O15 = 610.56
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus aurantium L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    新橙皮苷 CFN99125 13241-33-3 10mg QQ客服:1457312923
    新橙皮苷 CFN99125 13241-33-3 20mg QQ客服:1457312923
    新橙皮苷 CFN99125 13241-33-3 50mg QQ客服:1457312923
    新橙皮苷 CFN99125 13241-33-3 100mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • Weizmann Institute of Science (Israel)
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  • ...
  • 生物活性
    Description: Neohesperidin, a natural new nutrition sweetener, has antioxidant (IC50=22.31ug/mL), anti-inflammatory, and neuroprotective effects. It can attenuate cerebral ischemia-reperfusion injury via the inhibition of neuronal and oxidative stress through the regulation of the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway, it may be useful for the treatment and/or protection of gastritis.
    Targets: Beta Amyloid | ROS | Calcium Channel | HO-1 | Nrf2 | Akt | Caspase | Bcl-2/Bax | TNF-α | COX
    In vitro:
    Curr Alzheimer Res. 2015;12(5):424-33.
    Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity.[Pubmed: 25938872]
    Being one of the hallmarks of Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress.
    In this work, among the 35 chemical components of Chinese herbal medicines (CHMs) being screened for inhibitors of Aβ aggregation, four of them, namely albiflorin, aloeemodin, neohesperidin and physcion, were found for the first time to exhibit a potent inhibitory effect on Aβ(1-40) and Aβ(1-42) aggregation. Their neuroprotective capability on primary hippocampal neuronal cells was also investigated by MTT assay, ROS assay and intracellular calcium(II) ion concentration measurement.
    It was interesting to find that physcion was rather toxic to neuronal cells while albiflorin, aloeemodin and neohesperidin reduced the toxicity and ROS induced by both monomeric and oligomeric Aβ species. In addition, albiflorin was particularly powerful in maintaining the intracellular Ca(2+) concentration.
    In vivo:
    J Asian Nat Prod Res. 2013 Sep;15(9):1023-37.
    Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway.[Pubmed: 23952707]
    Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. On the basis of this fact, antioxidative agents have been demonstrated to be neuroprotective. Neohesperidin (NH) is abundant in citrus flavonoids and possesses reactive oxygen species scavenging activity and neuroprotective effects in vitro. However, little is known about its effects on cerebral ischemia-reperfusion injury and the underlying mechanisms.
    In this study, we use a rat model of middle cerebral artery occlusion (MCAO) to investigate the neuroprotective effects of NH. NH significantly improved neurological functions and attenuated MCAO-induced infarct volume, pathological changes, and neuronal loss. Moreover, it enhanced antioxidant capacity and suppressed oxidative stress in the brain. NH inhibited the MCAO-induced upregulation of Bax, cytochrome c, and cleaved caspase-9 and -3, as well as the downregulation of Bcl-2. Interestingly, NH treatment upregulated heme oxygenase-1 (HO-1) in a concentration-dependent manner, which was due to the NH-mediated activation of the protein kinase B (Akt)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. NH also abolished the MCAO-induced inhibition of the Akt/Nrf2 pathway.
    In conclusion, NH attenuates cerebral ischemia-reperfusion injury via the inhibition of neuronal apoptosis and oxidative stress through the regulation of the apoptotic pathway and the Akt/Nrf2/HO-1 pathway. NH might be a promising preventive agent for ischemic stroke.
    Phytother Res. 2009 Dec;23(12):1748-53
    Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.[Pubmed: 19367677]

    The effects of Poncirus trifoliata (P. trifoliata) (Ponciri Fructus, PF) extract and its constituents such as neohesperidin and poncirin on gastritis in rats and human gastric cancer cells were investigated. The PF 70% ethanol extracts (1 g) showed approximately 11.38% of acid-neutralizing capacities and cytotoxicity (IC50=85.39 microg/mL) against human AGS gastric cancer cells. In addition, neohesperidin exhibited antioxidant activity (IC50=22.31 microg/mL) in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) and poncirin (100 mg/kg) significantly inhibited 55.0% and 60.0% of HCl/ethanol-induced gastric lesions, respectively, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH.
    From these results, it could be suggested that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6378 mL 8.1892 mL 16.3784 mL 32.7568 mL 40.946 mL
    5 mM 0.3276 mL 1.6378 mL 3.2757 mL 6.5514 mL 8.1892 mL
    10 mM 0.1638 mL 0.8189 mL 1.6378 mL 3.2757 mL 4.0946 mL
    50 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.6551 mL 0.8189 mL
    100 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.3276 mL 0.4095 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橙皮苷; Hesperidin CFN98839 520-26-3 C28H34O15 = 610.6 20mg QQ客服:215959384
    3''-O-咖啡酰橙皮苷; 3''-O-Caffeoylhesperidin CFN95564 N/A C37H40O18 = 772.7 5mg QQ客服:2159513211
    橙皮素5-O-葡萄糖苷; Hesperetin 5-O-glucoside CFN96023 69651-80-5 C22H24O11 = 464.4 5mg QQ客服:2056216494
    桃苷; Persicoside CFN97908 28978-03-2 C23H26O11 = 478.5 5mg QQ客服:1413575084
    甲基橙皮甙; 甲基橙皮苷; Methyl hesperidin CFN99584 11013-97-1 C29H36O15 = 624.59 20mg QQ客服:1413575084
    地奥司明杂质8; Diosmin Impurity 8 CFN95309 28719-21-3 C30H38O15 = 638.6 10mg QQ客服:2056216494
    (R)-5,3'-二甲基橙皮苷; (R)-5,3'-Dimethyl hesperidin CFN95310 N/A C30H38O15 = 638.6 5mg QQ客服:2056216494
    新橙皮苷; Neohesperidin CFN99125 13241-33-3 C28H34O15 = 610.56 20mg QQ客服:215959384
    圣草酚-8-葡萄糖苷; Eriodictyol-8-glucoside CFN91942 153733-96-1 C21H22O11 = 450.39 5mg QQ客服:215959384
    (R)-圣草酚-8-C-beta-D-葡萄糖苷; (R)-Eriodictyol-8-C-beta-D-glucopyranoside CFN91943 1023271-51-3 C21H22O11 = 450.39 5mg QQ客服:215959384





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