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  • 新北美圣草苷

    Neoeriocitrin

    新北美圣草苷
    产品编号 CFN92304
    CAS编号 13241-32-2
    分子式 = 分子量 C27H32O15 = 596.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus sinensis (L.) Osbeck
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新北美圣草苷 CFN92304 13241-32-2 10mg QQ客服:2159513211
    新北美圣草苷 CFN92304 13241-32-2 20mg QQ客服:2159513211
    新北美圣草苷 CFN92304 13241-32-2 50mg QQ客服:2159513211
    新北美圣草苷 CFN92304 13241-32-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • S.N.D.T. Women's University (India)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Weizmann Institute of Science (Israel)
  • University of Beira Interior (Portugal)
  • Kyung Hee University (Korea)
  • Shanghai University of TCM (China)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Mahidol University (Thailand)
  • University of Pretoria (South Africa)
  • Imperial College London (United Kingdom)
  • University of Medicine and Pharmacy (Romania)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Prolif.2021, 54(8):e13083.
  • Plant Archives2020, 2(1),2929-2934
  • J Ginseng Res.2020, 44(4):611-618.
  • J Chromatogr A.2022, 1685:463640.
  • Front Pharmacol.2021, 12:764297.
  • Molecules. 2013, 18(11):14105-21
  • Eur J Pharmacol.2022, 917:174744.
  • Sci Rep.2015, 5:13194
  • JOTCSA.2023, 10(4); 893-902.
  • J Immunol.2023, ji2200727.
  • J Ethnopharmacol.2019, 236:31-41
  • American Association for Anatomy2020, doi: 10.1002.
  • Pharmaceutics.2020, 12(9):845.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Biosci. Rep.2020, 10.1024
  • Neurotox Res.2020, 38(1):163-174.
  • Univerzita Karlova2022, 228192.
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Eur J Pharmacol.2021, 906:174220.
  • Mol Med Rep.2022, 25(1):8.
  • Acta horticulturae2017, 1158:257-268
  • Nat Prod Commun.2017, 12(5):771-778
  • J Appl Microbiol.2022, 132(2):949-963.
  • ...
  • 生物活性
    Description: Neoeriocitrin has antioxidant capacity, it could rescue the inhibition effect of cell differentiation induced by PD98059 to some degree.Neoeriocitrin may be a new promising candidate drug for treatment of osteoporosis.
    Targets: LDL | Runx2 | COLI | OCN
    In vitro:
    Phytomedicine. 2011 Aug 15;18(11):985-9.
    Comparison of neoeriocitrin and naringin on proliferation and osteogenic differentiation in MC3T3-E1.[Pubmed: 21741227]
    Naringin is considered the main effective compound of Drynaria Rhizome, which is used commonly in the treatment of osteoporosis in traditional Chinese medicine. However, we found neoeriocitrin, a new compound isolated from Drynaria Rhizome, showed a better activity than naringin on proliferation and osteogenic differentiation in MC3T3-E1.
    METHODS AND RESULTS:
    Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2μg/ml. Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2, COLI and OCN expression by 56%, 37% and 14% respectively than naringin. Furthermore, neoeriocitrin could rescue the inhibition effect of cell differentiation induced by PD98059 to some degree.
    CONCLUSIONS:
    Therefore, neoeriocitrin may be a new promising candidate drug for treatment of osteoporosis.
    J Agric Food Chem. 2005 Mar 23;53(6):2009-14.
    Antioxidant activity of citrus limonoids, flavonoids, and coumarins.[Pubmed: 15769128 ]

    METHODS AND RESULTS:
    A variety of in vitro models such as beta-carotene-linoleic acid, 1,1-diphenyl-2-picryl hydrazyl (DPPH), superoxide, and hamster low-density lipoprotein (LDL) were used to measure the antioxidant activity of 11 citrus bioactive compounds. The compounds tested included two limonoids, limonin (Lim) and limonin 17-beta-D-glucopyranoside (LG); eight flavonoids, apigenin (Api), scutellarein (Scu), kaempferol (Kae), rutin trihydrate (Rut), neohesperidin (Neh), neoeriocitrin (Nee), naringenin (Ngn), and naringin(Ng); and a coumarin (bergapten). The above compounds were tested at concentration of 10 microM in all four methods. It was found that Lim, LG, and Ber inhibited <7%, whereas Scu, Kae, and Rut inhibited 51.3%, 47.0%, and 44.4%, respectively, using the beta-carotene-linoleate model system. Lim, LG, Rut, Scu, Nee, and Kae showed 0.5% 0.25%, 32.2%, 18.3%, 17.2%, and 12.2%, respectively, free radical scavenging activity using the DPPH method. In the superoxide model, Lim, LG, and Ber inhibited the production of superoxide radicals by 2.5-10%, while the flavonoids such as Rut, Scu, Nee, and Neh inhibited superoxide formation by 64.1%, 52.1%, 48.3%, and 37.7%, respectively. However, LG did not inhibit LDL oxidation in the hamster LDL model. But, Lim and Ber offered some protection against LDL oxidation, increasing lag time to 345 min (3-fold) and 160 min (33% increase), respectively, while both Rut and Nee increased lag time to 2800 min (23-fold). Scu and Kae increased lag time to 2140 min (18-fold) and 1879 min (15.7-fold), respectively. In general, it seems that flavonoids, which contain a chromanol ring system, had stronger antioxidant activity as compared to limonoids and bergapten, which lack the hydroxy groups.
    CONCLUSIONS:
    The present study confirmed that several structural features were linked to the strong antioxidant activity of flavonoids. This is the first report on the antioxidant activity of limonin, limonin glucoside, and neoeriocitrin.
    J Sep Sci . 2020 Apr;43(8):1531-1543.
    Extraction and isolation of acetylcholinesterase inhibitors from Citrus limon peel using an in vitro method[Pubmed: 31999045]
    Abstract A simple and efficient ultrafiltration-liquid chromatography-mass spectrometry-based method was developed for the rapid screening and identification of ligands from Citrus limon peel, which are suitable acetylcholinesterase inhibitors. Subsequently, the anti-Alzheimer's activity of these compounds was assessed using a PC12 cell model. Six major compounds, viz. neoeriocitrin, isonaringin, naringin, hesperidin, neohesperidin, and limonin, were identified as potent acetylcholinesterase inhibitors. A continuous and efficient online method, which involved the use of a microwave-assisted extraction device, solvent concentration tank, and centrifugal partition chromatography column, was developed for the scale-up of these compounds, and the obtained compounds presented high purity. Next, their bioactivity was evaluated using a PC12 cell model. This novel approach, which was based on ultrafiltration-liquid chromatography-mass spectrometry, microwave-assisted extraction online coupled with solvent concentration tank, and centrifugal partition chromatography along with in vitro evaluation, could represent a powerful tool for the screening and extraction of acetylcholinesterase inhibitors from complex matrices, and could be a useful platform for the large-scale production of bioactive and nutraceutical ingredients. Keywords: Alzheimer's disease; acetylcholinesterase inhibitors; centrifugal partition chromatography; citrus limon.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3822 mL 16.7645 mL 33.5289 mL 41.9111 mL
    5 mM 0.3353 mL 1.6764 mL 3.3529 mL 6.7058 mL 8.3822 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3529 mL 4.1911 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6706 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    圣草次甙; 圣草次苷; Eriocitrin CFN99718 13463-28-0 C27H32O15 = 596.53 20mg QQ客服:215959384
    橙皮素7-O-葡萄糖苷; Hesperetin 7-O-glucoside CFN98405 31712-49-9 C22H24O11 = 464.4 10mg QQ客服:3257982914
    橙皮苷; Hesperidin CFN98839 520-26-3 C28H34O15 = 610.6 20mg QQ客服:1413575084
    3''-O-咖啡酰橙皮苷; 3''-O-Caffeoylhesperidin CFN95564 N/A C37H40O18 = 772.7 5mg QQ客服:1413575084
    橙皮素5-O-葡萄糖苷; Hesperetin 5-O-glucoside CFN96023 69651-80-5 C22H24O11 = 464.4 5mg QQ客服:3257982914
    桃苷; Persicoside CFN97908 28978-03-2 C23H26O11 = 478.5 5mg QQ客服:1413575084
    甲基橙皮甙; 甲基橙皮苷; Methyl hesperidin CFN99584 11013-97-1 C29H36O15 = 624.59 20mg QQ客服:2159513211
    地奥司明杂质8; Diosmin Impurity 8 CFN95309 28719-21-3 C30H38O15 = 638.6 10mg QQ客服:2056216494
    (R)-5,3'-二甲基橙皮苷; (R)-5,3'-Dimethyl hesperidin CFN95310 N/A C30H38O15 = 638.6 5mg QQ客服:1457312923
    新橙皮苷; Neohesperidin CFN99125 13241-33-3 C28H34O15 = 610.56 20mg QQ客服:1457312923

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