| In vitro: |
| J Ethnopharmacol. 2004 Aug;93(2-3):243-6. | | Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.[Pubmed: 15234759 ] |
METHODS AND RESULTS:
The methylene chloride extract of the root of Angelicae dahuricae showed high protective activity against 2,2'-azobis (2-aminodinopropane) dihydrochloride (AAPH)-induced cellular damage. From this extract, 11 furanocoumarins were isolated, namely oxypeucedanin hydrate, 9-hydroxy-4-methoxypsoralen, byakangelicin, pabulenol, alloisoimperatorin, Neobyakangelicol, byakangelicol, oxypeucedanin, imperatorin, phellotorin and isoimperatorin, respectively.
CONCLUSIONS:
Among these 11 furanocoumarins, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin displayed potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. | | Planta Med. 1982 Jul;45(3):183-7. | | Effects of various coumarins from roots of Angelica dahurica on actions of adrenaline, ACTH and insulin in fat cells.[Reference: WebLink] |
METHODS AND RESULTS:
Experiments were carried out on the effects of various coumarins on the actions of adrenaline, adrenocorticotropic hormone (ACTH) and insulin in fat cells isolated from rats. Furocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin, phellopterin activated adrenaline-induced lipolysis. Furocoumarins such as oxypeucedanin hydrate, imperatorin and phellopterin also activated ACTH-induced lipolysis. On the other hand, furocoumarins such as byak-angelicin, Neobyakangelicol and isopimpinellin strongly inhibited insulin-stimulated lipogenesis.
CONCLUSIONS:
Therefore, the crude drug “Byakushi” may activate the actions of lipolytic hormones and selectively inhibit the effects of anti-lipolytic hormones. |
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