| Description: |
Byakangelicin is found in extracts of the root of Angelica dahurica, used in Korea and China as a traditional medicine to treat colds, headache and toothache, it can inhibit the effects of sex hormones, it may increase the catabolism of endogenous hormones, it induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes. Byakangelicin is effective for the treatment of sugar cataracts and diabetic neuropathy in rats. Byakangelicin could as insecticides and insect antifeedant for the control of Lepidoptera and Homoptera showed a significant effect. |
| Targets: |
P450 (e.g. CYP17) | Sodium Channel | ATPase | Potassium Channel |
| In vitro: |
| CN 103109822 A[P]. 2013. | | Application of byakangelicin used as agricultural insect antifeedant and pesticide.[Reference: WebLink] | | The invention discloses an application of byakangelicin used as an agricultural pesticide and an insect antifeedant. The byakangelicin has an obvious effect of preventing and controlling lepidopterous insects and homoptera when being used as the pesticide and the insect antifeedant, and also has the characteristics of low toxicity without any residues or pollutions when being used as the agricultural pesticide, so that environmental protection is favored. |
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| In vivo: |
| Phytomedicine. 1998 Apr;5(2):121-7. | | Effect of byakangelicin, an aldose reductase inhibitor, on galactosemic cataracts, the polyol contents and Na(+), K(+)ATPase activity in sciatic nerves of strepto-zotocin-induced diabetic rats.[Pubmed: 23195764] | Byakangelicin, a main furanocoumarin constituent isolated and characterized as an aldose reductase inhibitor from the roots of Angelica dahurica, was evaluated for usefulness in the treatment of galactosemic cataract and diabetic complications in animal experiments.
METHODS AND RESULTS:
Cataract formation and galactitol accumulation in the lenses of rats fed a 30% galactose diet were significantly prevented by intragastric (i.g.) administration of byakangelicin at a dose of 100 mg/kg for 14 days. Administration of the drug for 18 days was found to suppress sorbitol accumulation and cause a significant reversal of depleted myo-inositol contents as well as Na(+),K(+)ATPase activity in the sciatic nerves of streptozotocin-induced diabetic rats.
CONCLUSIONS:
These results indicate that in rats, byakangelicin is effective for the treatment of sugar cataracts and diabetic neuropathy and hence might be useful as a lead compound for the development of new type drugs for clinical use. |
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