大果桉醛C

Macrocarpal C

	产品编号	CFN99469
	CAS编号	142628-53-3
	分子式 = 分子量	C₂₈H₃₈O₅ = 454.6
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Sesquiterpenoids
	植物来源	The branches of Eucalyptus globulus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
大果桉醛C	CFN99469	142628-53-3	1mg	QQ客服：1457312923
大果桉醛C	CFN99469	142628-53-3	5mg	QQ客服：1457312923
大果桉醛C	CFN99469	142628-53-3	10mg	QQ客服：1457312923
大果桉醛C	CFN99469	142628-53-3	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Helsinki (Finland)

Mendel University in Brno (Czech Republic)

Colorado State University (USA)

Shanghai University of TCM (China)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Universidad Veracuzana (Mexico)

The Vancouver Prostate Centre (VPC) (Canada)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Semmelweis Unicersity (Hungary)

Cornell University (USA)

Max Rubner-Institut (MRI) (Germany)

The University of Newcastle (Australia)

Aarhus University (Denmark)

University of Fribourg (Switzerland)

More...

Description:

Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.

Targets:

ROS | Antifection

In vitro:

Am J Chin Med. 2010;38(5):1005-14.

Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification.[Pubmed: 20821830]

Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification.
METHODS AND RESULTS:
Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst Macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro.
CONCLUSIONS:
This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

Chin Med. 2015 Nov 21;10:34.

Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes.[Pubmed: 26594235 ]

The fresh leaves of Eucalyptus globulus Labill. (Lan An) have been used in Chinese medicine for many years to treat dermatomycosis. Macrocarpal C was isolated from this herb and identified as its major antifungal component by bioassay-guided purification. This study aims to investigate the antifungal activity of Macrocarpal C against Trichophyton mentagrophytes, which can cause tinea pedis.
METHODS AND RESULTS:
The suppression in the growth of T. mentagrophytes following its treatment with Macrocarpal C was associated with an increase in the permeability of the fungal membrane (P = 0.0043 when compared to control); an increase in the production of intracellular ROS (P = 0.0063); and the induction of apoptosis as a consequence of DNA fragmentation (P = 0.0007). CONCLUSION:
CONCLUSIONS:
This study demonstrated that the antifungal action of Macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
大果桉醛C; Macrocarpal C	CFN99469	142628-53-3	C₂₈H₃₈O₅ = 454.6	5mg	QQ客服：2056216494
大果桉醛A; Macrocarpal A	CFN99413	132951-90-7	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：3257982914
大果桉醛B; Macrocarpal B	CFN99472	142698-60-0	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：2159513211
大果桉醛D; Macrocarpal D	CFN99471	142647-71-0	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：3257982914
桉树脑; Eucalyptone	CFN99813	172617-99-1	C₂₈H₃₈O₇ = 486.6	5mg	QQ客服：215959384
大果桉醛N; Macrocarpal N	CFN99008	221899-21-4	C₂₈H₃₈O₇ = 486.6	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1997 mL	10.9987 mL	21.9974 mL	43.9947 mL	54.9934 mL
5 mM	0.4399 mL	2.1997 mL	4.3995 mL	8.7989 mL	10.9987 mL
10 mM	0.22 mL	1.0999 mL	2.1997 mL	4.3995 mL	5.4993 mL
50 mM	0.044 mL	0.22 mL	0.4399 mL	0.8799 mL	1.0999 mL
100 mM	0.022 mL	0.11 mL	0.22 mL	0.4399 mL	0.5499 mL

大果桉醛C

Macrocarpal C

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