大果桉醛C

Macrocarpal C

	产品编号	CFN99469
	CAS编号	142628-53-3
	分子式 = 分子量	C₂₈H₃₈O₅ = 454.6
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Sesquiterpenoids
	植物来源	The branches of Eucalyptus globulus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
大果桉醛C	CFN99469	142628-53-3	1mg	QQ客服：2056216494
大果桉醛C	CFN99469	142628-53-3	5mg	QQ客服：2056216494
大果桉醛C	CFN99469	142628-53-3	10mg	QQ客服：2056216494
大果桉醛C	CFN99469	142628-53-3	20mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Johannes Gutenberg University Mainz (JGU) (Germany)

Wageningen University (Netherlands)

Gyeongsang National University (Korea)

University of East Anglia (United Kingdom)

Universita' Degli Studi Di Cagliari (Italy)

The University of Newcastle (Australia)

University of Cincinnati (USA)

Mahidol University (Thailand)

Pennsylvania State University (USA)

University of Illinois at Chicago (USA)

Melbourne University (Australia)

Siksha O Anusandhan University (India)

Biotech R&D Institute (USA)

Vin?a Institute of Nuclear Sciences (Serbia)

More...

Description:

Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.

Targets:

ROS | Antifection

In vitro:

Am J Chin Med. 2010;38(5):1005-14.

Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification.[Pubmed: 20821830]

Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification.
METHODS AND RESULTS:
Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst Macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro.
CONCLUSIONS:
This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

Chin Med. 2015 Nov 21;10:34.

Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes.[Pubmed: 26594235 ]

The fresh leaves of Eucalyptus globulus Labill. (Lan An) have been used in Chinese medicine for many years to treat dermatomycosis. Macrocarpal C was isolated from this herb and identified as its major antifungal component by bioassay-guided purification. This study aims to investigate the antifungal activity of Macrocarpal C against Trichophyton mentagrophytes, which can cause tinea pedis.
METHODS AND RESULTS:
The suppression in the growth of T. mentagrophytes following its treatment with Macrocarpal C was associated with an increase in the permeability of the fungal membrane (P = 0.0043 when compared to control); an increase in the production of intracellular ROS (P = 0.0063); and the induction of apoptosis as a consequence of DNA fragmentation (P = 0.0007). CONCLUSION:
CONCLUSIONS:
This study demonstrated that the antifungal action of Macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
大果桉醛C; Macrocarpal C	CFN99469	142628-53-3	C₂₈H₃₈O₅ = 454.6	5mg	QQ客服：2159513211
大果桉醛A; Macrocarpal A	CFN99413	132951-90-7	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：215959384
大果桉醛B; Macrocarpal B	CFN99472	142698-60-0	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：215959384
大果桉醛D; Macrocarpal D	CFN99471	142647-71-0	C₂₈H₄₀O₆ = 472.6	5mg	QQ客服：2056216494
桉树脑; Eucalyptone	CFN99813	172617-99-1	C₂₈H₃₈O₇ = 486.6	5mg	QQ客服：3257982914
大果桉醛N; Macrocarpal N	CFN99008	221899-21-4	C₂₈H₃₈O₇ = 486.6	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1997 mL	10.9987 mL	21.9974 mL	43.9947 mL	54.9934 mL
5 mM	0.4399 mL	2.1997 mL	4.3995 mL	8.7989 mL	10.9987 mL
10 mM	0.22 mL	1.0999 mL	2.1997 mL	4.3995 mL	5.4993 mL
50 mM	0.044 mL	0.22 mL	0.4399 mL	0.8799 mL	1.0999 mL
100 mM	0.022 mL	0.11 mL	0.22 mL	0.4399 mL	0.5499 mL

大果桉醛C

Macrocarpal C

信息支持

联系方式