马卡因; 高丽槐素
Maackiain
|
|
产品编号 |
CFN99746 |
| CAS编号 |
19908-48-6 |
| 分子式 = 分子量 |
C16H12O5 = 284.27 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The flowers of Maackia amurensis Rupr.et Maxim. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 马卡因; 高丽槐素 |
CFN99746 |
19908-48-6 |
10mg |
QQ客服：1457312923 |
| 马卡因; 高丽槐素 |
CFN99746 |
19908-48-6 |
20mg |
QQ客服：1457312923 |
| 马卡因; 高丽槐素 |
CFN99746 |
19908-48-6 |
50mg |
QQ客服：1457312923 |
| 马卡因; 高丽槐素 |
CFN99746 |
19908-48-6 |
100mg |
QQ客服：1457312923 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
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Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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University of Zurich (Switzerland)
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University of Bordeaux (France)
Charles Sturt University (Denmark)
Celltrion Chemical Research Institute (Korea)
Universidad Miguel Hernández (Spain)
Lund University (Sweden)
Kazusa DNA Research Institute (Japan)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Maackiain is an antimicrobial compound (phytoalexins), it has anticancer effects, it induces apoptosis and growth suppression. Maackiain also shows strong larvicidal activity (LC50 = 21.95 ± 1.34 ug/mL). |
| Targets: |
Antifection |
| In vitro: |
| Exp Parasitol. 2015 Jun;153:160-4. | | Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.[Pubmed: 25819294] |
METHODS AND RESULTS:
The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines.
Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 µg/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC₅₀ = 34.90 ± 1.27 µg/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC₅₀ = 17.5 ± 1.87 µg/mL) and maackiain showed to be a strong larvicidal compound (LC₅₀ = 21.95 ± 1.34 µg/mL).
CONCLUSIONS:
This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector. | | Oncol Rep. 2004 Dec;12(6):1183-8. | | Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.[Pubmed: 15547735] |
METHODS AND RESULTS:
We have investigated the effects of maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) on DNA of human promyelotic HL-60 leukemia cells. It was found that extent of induction of apoptosis by maackiain was larger than that by trifolirhizin in human leukemia HL-60 cells. Morphological changes showing apoptotic bodies were observed in the HL-60 cells treated with maackiain and trifolirhizin. The fragmentations of DNA by maackiain and trifolirhizin to oligonucleosomal-sized fragments that is a characteristic of apoptosis was observed to be concentration- and time-dependent in the HL-60 cells.
CONCLUSIONS:
The data of the present study show that the suppressions by maackiain and trifolrhizin of growth of the HL-60 cells result from the induction of apoptosis by these compounds, and that the extent of growth suppression and induction of apoptosis by maackiain was greater than that by the glycoside (trifolirhizin). |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.5178 mL |
17.5889 mL |
35.1778 mL |
70.3556 mL |
87.9446 mL |
| 5 mM |
0.7036 mL |
3.5178 mL |
7.0356 mL |
14.0711 mL |
17.5889 mL |
| 10 mM |
0.3518 mL |
1.7589 mL |
3.5178 mL |
7.0356 mL |
8.7945 mL |
| 50 mM |
0.0704 mL |
0.3518 mL |
0.7036 mL |
1.4071 mL |
1.7589 mL |
| 100 mM |
0.0352 mL |
0.1759 mL |
0.3518 mL |
0.7036 mL |
0.8794 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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