3,9-二甲氧基紫檀碱; 高紫檀素

Homopterocarpin

	产品编号	CFN97720
	CAS编号	606-91-7
	分子式 = 分子量	C₁₇H₁₆O₄ = 284.31
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Flavonoids
	植物来源	The roots of Sophora tonkinensis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
3,9-二甲氧基紫檀碱; 高紫檀素	CFN97720	606-91-7	1mg	QQ客服：1413575084
3,9-二甲氧基紫檀碱; 高紫檀素	CFN97720	606-91-7	5mg	QQ客服：1413575084
3,9-二甲氧基紫檀碱; 高紫檀素	CFN97720	606-91-7	10mg	QQ客服：1413575084
3,9-二甲氧基紫檀碱; 高紫檀素	CFN97720	606-91-7	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property of P. erinaceus. Homopterocarpin can contribute to the hepatoprotective and antioxidant potentials of P. erinaceus extract in acetaminophen-provoked hepatotoxicity. It can inhibit (lower concentration) or kill (higher concntration) human^s liver cancer cells under the cultured condition, they have anticancer activity. (-)-Homopterocarpin has active insect antifeedant against both S. litura and R. speratus. (+)-Homopterocarpin also has antimitotic effect.

Targets:

Antifection

In vitro:

Journal of Shenyang Pharmaceutical University,2001, 18(3):211-212.

The inhibitory effects of homopterocarpin and medicarpin on human^s liver cancer cells in vitro[Reference: WebLink]

An observation on the anticancer activity of Homopterocarpin and medicarpin in vitro, which was separated from the root of Glycyrrhiza pallidiflora Maxim.
METHODS AND RESULTS:
The cell culture test was used in these studies in vitro. The experimental result showed that these two ingredients could inhibite (lower concentration) or kill (higher concntration) human^s liver cancer cells under the cultured condition, moreover, the effect of medicarpin was stronger than that of Homopterocarpin.
CONCLUSIONS:
These two monomers were active components of Glycyrrhiza pallidiflora Maxim.

In vivo:

J Basic Clin Physiol Pharmacol. 2015 Mar 26.

Effect of homopterocarpin, an isoflavonoid from Pterocarpus erinaceus, on indices of liver injury and oxidative stress in acetaminophen-provoked hepatotoxicity.[Pubmed: 25811665]

Novel hepatoprotectives are needed to address the increasing cases of liver problems worldwide. Pterocarpus erinaceus Poir (Fabaceae) ethanol stem bark extract (PE) and its constituent flavonoid, homopterocarpin (HP), were investigated for their protective property in acetaminophen-induced oxidative stress and liver damage.
METHODS AND RESULTS:
Adult male albino rats were divided into nine groups. Seven groups were pretreated with PE (50-, 100-, and 150 mg/kg), HP (25-, 50-, and 75 mg/kg) or silymarin (25 mg/kg), respectively, once daily for 5 consecutive days and then administered acetaminophen (2 g/kg) on the 5th day. The control and acetaminophen-intoxicated groups received normal saline throughout the experimental period, with the latter group additionally receiving 2 g/kg acetaminophen on the 5th day. Administrations were performed po. In the acetaminophen-intoxicated group, there were significant increases (p<0.05) in serum activities of alanine aminotransferase (31.72±3.3 vs. 22.1±1.2 U/I), aspartate aminotransferase (185.1±10.1 vs. 103.83±13.3 U/I), bilirubin level and hepatic malondialdehyde (2.32±0.3 vs. 1.42±0.1 units/mg protein), accompanied with significant decreases (p<0.05) in hepatic reduced glutathione level (0.10±0.01 vs. 0.23±0.03 units/mg protein) and glutathione peroxidase activity (2.51±0.2 vs. 3.25±0.2 μmol H2O2 consumed/min/mg protein) compared with the control.
CONCLUSIONS:
PE and HP ameliorated most of the observed biochemical alterations with HP appearing to show more potency. The results suggest that the flavonoid, homopterocarpin contributes to the hepatoprotective and antioxidant potentials of P. erinaceus extract.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(-)-Variabilin; (-)-Variabilin	CFN97945	370102-93-5	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：3257982914
3-羟基-9,10-二甲氧基紫檀烷; Methylnissolin	CFN90838	73340-41-7	C₁₇H₁₆O₅ = 300.3	10mg	QQ客服：1413575084
美迪紫檀苷; Methylnissolin-3-O-glucoside	CFN93199	94367-42-7	C₂₃H₂₆O₁₀ = 462.5	20mg	QQ客服：1457312923
3-Hydroxy-8,9-methylenedioxypterocarpene; 3-Hydroxy-8,9-methylenedioxypterocarpene	CFN96063	59901-98-3	C₁₆H₁₀O₅ = 282.3	5mg	QQ客服：215959384
马卡因; 高丽槐素; Maackiain	CFN99746	19908-48-6	C₁₆H₁₂O₅ = 284.27	20mg	QQ客服：1457312923
红车轴草根甙；三叶豆紫檀苷; Trifolirhizin	CFN97160	6807-83-6	C₂₂H₂₂O₁₀ = 446.4	20mg	QQ客服：2056216494
6alpha-羟基高丽槐素; 6alpha-Hydroxymaackiain	CFN96037	61218-44-8	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：2159513211
豌豆素; Pisatin	CFN96000	20186-22-5	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：3257982914
Sophoracarpan A ; Sophoracarpan A	CFN96672	1674359-82-0	C₁₇H₁₆O₅ = 300.31	5mg	QQ客服：215959384
Sophoracarpan B ; Sophoracarpan B	CFN96671	1674359-84-2	C₁₇H₁₄O₆ = 314.30	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL	70.3457 mL	87.9322 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL	14.0691 mL	17.5864 mL
10 mM	0.3517 mL	1.7586 mL	3.5173 mL	7.0346 mL	8.7932 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.4069 mL	1.7586 mL
100 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.7035 mL	0.8793 mL

3,9-二甲氧基紫檀碱; 高紫檀素

Homopterocarpin

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