西伯利亚落叶松黄酮

Laricitrin

	产品编号	CFN70400
	CAS编号	53472-37-0
	分子式 = 分子量	C₁₆H₁₂O₈ = 332.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Astragalus complanatus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
西伯利亚落叶松黄酮	CFN70400	53472-37-0	1mg	QQ客服：3257982914
西伯利亚落叶松黄酮	CFN70400	53472-37-0	5mg	QQ客服：3257982914
西伯利亚落叶松黄酮	CFN70400	53472-37-0	10mg	QQ客服：3257982914
西伯利亚落叶松黄酮	CFN70400	53472-37-0	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Laricitrin is a novel flavonoid ABCG2 inhibitor, it suppresses certain factors and decreases the progression of lung cancer cells that are promoted by BaP in the lung cancer tumor microenvironment. Laricitrin could be an efficacious immunoadjuvant and have a synergistic effect when combined with chemotherapy.

Targets:

ABCG2 | BaP | BRAF | STAT3 | CD4+

In vitro:

Oncology Letters, 26 Jan 2016, 11(3):1783-1790.

Laricitrin suppresses increased benzo(a)pyrene-induced lung tumor-associated monocyte-derived dendritic cell cancer progression.[Reference: WebLink]

Benzo(a)pyrene (BaP) stimulates lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including heparin binding-epidermal growth factor and C-X-C motif chemokine 5. The secretions from monocyte-derived dendritic cells stimulate the progression of lung cancer cells, including the migration and invasion of cells. To the best of our knowledge, these secretions remain unknown, and require additional study.
METHODS AND RESULTS:
The present study identified that treatment with BaP-H1395-tumor-associated dendritic cell-conditioned medium had the most marked effect on cell migration and invasion. This result may be associated with the female gender, stage 2 adenocarcinoma or mutation of the proto-oncogene B-Raf (BRAF), according to the cell line background. Laricitrin, a dietary flavonoid derivative present in grapes and red wine, suppresses certain factors and decreases the progression of lung cancer cells that are promoted by BaP in the lung cancer tumor microenvironment.
CONCLUSIONS:
The results of the present study suggest that prolonged exposure to BaP exacerbates lung cancer, particularly in female lung cancer patients with the BRAF mutation, but that laricitrin may ameliorate this effect.

Oncotarget, 2016, 7(51):85220.

Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3.[Reference: WebLink]

Natural polyphenolic compounds of grapes and their seeds are thought to be therapeutic adjuvants in a variety of diseases, including cancer prevention. This study was carried out to investigate the effect of grape phenolic compounds on the regulation of cancer-mediated immune suppression.
METHODS AND RESULTS:
Laricitrin exhibits the greatest potential to ameliorate the suppressive effects of lung cancer on dendritic cells' (DCs') differentiation, maturation and function. Human lung cancer A549 and CL1-5 cells change the phenotype of DCs that express to high levels of IL-10 and prime T cells towards an immune suppression type-2 response (Th2). Laricitrin treatment stimulated DC differentiation and maturation in the condition media of cancer cells, a finding supported by monocyte marker CD14's disappearance and DC marker CD1a's upregulation. Laricitrin decreases expression of IL-10 in cancer-conditioned DCs, and subsequently switches CD4+ T cell response from Th2 to Th1 in vitro and in vivo. Reversal of laricitrin on lung cancer-induced DCs' paralysis was via inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Laricitrin also potentiated the anticancer activity of cisplatin in mouse models.
CONCLUSIONS:
Thus, laricitrin could be an efficacious immunoadjuvant and have a synergistic effect when combined with chemotherapy.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Combretol; Combretol	CFN91118	5084-19-5	C₂₀H₂₀O₈ = 388.4	10mg	QQ客服：1457312923
5,7,3',4',5'-五甲氧基黄酮; 5,7,3',4',5'-Pentamethoxyflavone	CFN91117	53350-26-8	C₂₀H₂₀O₇ = 372.4	20mg	QQ客服：1413575084
8-羟基-3,5,7,3',4',5'-六甲氧基黄酮; 8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone	CFN98025	202846-95-5	C₂₁H₂₂O₉ = 418.4	5mg	QQ客服：2159513211
3',4',5',3,5,7,8-七甲氧基黄酮; 3',4',5',3,5,7,8-Heptamethoxyflavone	CFN98076	21634-52-6	C₂₂H₂₄O₉ = 432.4	5mg	QQ客服：2056216494
8-羟基-3,5,6,7,3',4'-六甲氧基黄酮; 8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone	CFN90998	1000415-56-4	C₂₁H₂₂O₉ = 418.39	5mg	QQ客服：1413575084
Natsudaidain; Natsudaidain	CFN91804	35154-55-3	C₂₁H₂₂O₉ = 418.4	5mg	QQ客服：1457312923
3,3'',4'',5,5'',6,7-六甲氧基黄酮; 3',4',5',3,5,6,7-Heptamethoxyflavone	CFN99812	17245-30-6	C₂₂H₂₄O₉ = 432.4	5mg	QQ客服：1413575084
5,7-二羟基 3,3',4',5',6,8-六甲氧基黄酮; 5,7-Dihydroxy 3,3',4',5',6,8-hexamethoxyflavone	CFN70469	96887-18-2	C₂₁H₂₂O₁₀ = 434.4	5mg	QQ客服：1413575084
3,5,6,7,8,3',4',5'-八甲氧基黄酮; Exoticin	CFN99417	13364-94-8	C₂₃H₂₆O₁₀ = 462.5	5 mg	QQ客服：1457312923
粘毛黄芩素I; Viscidulin I	CFN97489	92519-95-4	C₁₅H₁₀O₇ = 302.2	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0093 mL	15.0466 mL	30.0933 mL	60.1866 mL	75.2332 mL
5 mM	0.6019 mL	3.0093 mL	6.0187 mL	12.0373 mL	15.0466 mL
10 mM	0.3009 mL	1.5047 mL	3.0093 mL	6.0187 mL	7.5233 mL
50 mM	0.0602 mL	0.3009 mL	0.6019 mL	1.2037 mL	1.5047 mL
100 mM	0.0301 mL	0.1505 mL	0.3009 mL	0.6019 mL	0.7523 mL

西伯利亚落叶松黄酮

Laricitrin

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