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  • 西伯利亚落叶松黄酮

    • 西伯利亚落叶松黄酮

    Laricitrin

    西伯利亚落叶松黄酮
    		产品编号 CFN70400
    CAS编号 53472-37-0
    分子式 = 分子量 C16H12O8 = 332.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Astragalus complanatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    西伯利亚落叶松黄酮 CFN70400 53472-37-0 1mg QQ客服：1457312923
    西伯利亚落叶松黄酮 CFN70400 53472-37-0 5mg QQ客服：1457312923
    西伯利亚落叶松黄酮 CFN70400 53472-37-0 10mg QQ客服：1457312923
    西伯利亚落叶松黄酮 CFN70400 53472-37-0 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Indian Institute of Science (India)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Sri Ramachandra University (India)
  • Utrecht University (Netherlands)
  • University of Perugia (Italy)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Queensland (Australia)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • National Research Council of Canada (Canada)
  • Universidad de Antioquia (Colombia)
  • Celltrion Chemical Research Institute (Korea)
  • National Cancer Institute (USA)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Funct.2022, 13(23):12105-12120.
  • Anal Bioanal Chem. 2016, 408(15)
  • Analytical Letters 2021, 54(4).
  • Biochem Pharmacol. 2020, 177:114014.
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Phytother Res.2019, 33(4):1104-1113
  • Int J Mol Med.2015, 35(5):1237-45
  • Sci Rep.2023, 13(1):13072.
  • Natural Product Communications2020, doi: 10.1177.
  • J Pharm Biomed Anal.2018, 151:32-41
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Front Pharmacol.2017, 8:673
  • Cell Prolif.2021, 54(8):e13083.
  • J of Archaeological Science:Reports2024, 53:104298
  • Mol Med Rep.2024, 29(2):26.
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
  • FARMACIA2023, Vol.71,3.
  • Sustainability2021, 13(23),12981.
  • Food Funct.2021, 12(13):5892-5902.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Natural Product Communications2022, 7(3):1-7.
  • Food Chem.2019, 276:768-775
  • ...
    • 生物活性
    Description: Laricitrin is a novel flavonoid ABCG2 inhibitor, it suppresses certain factors and decreases the progression of lung cancer cells that are promoted by BaP in the lung cancer tumor microenvironment. Laricitrin could be an efficacious immunoadjuvant and have a synergistic effect when combined with chemotherapy.
    Targets: ABCG2 | BaP | BRAF | STAT3 | CD4+
    In vitro:
    Oncology Letters, 26 Jan 2016, 11(3):1783-1790.
    Laricitrin suppresses increased benzo(a)pyrene-induced lung tumor-associated monocyte-derived dendritic cell cancer progression.[Reference: WebLink]
    Benzo(a)pyrene (BaP) stimulates lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including heparin binding-epidermal growth factor and C-X-C motif chemokine 5. The secretions from monocyte-derived dendritic cells stimulate the progression of lung cancer cells, including the migration and invasion of cells. To the best of our knowledge, these secretions remain unknown, and require additional study.
    METHODS AND RESULTS:
    The present study identified that treatment with BaP-H1395-tumor-associated dendritic cell-conditioned medium had the most marked effect on cell migration and invasion. This result may be associated with the female gender, stage 2 adenocarcinoma or mutation of the proto-oncogene B-Raf (BRAF), according to the cell line background. Laricitrin, a dietary flavonoid derivative present in grapes and red wine, suppresses certain factors and decreases the progression of lung cancer cells that are promoted by BaP in the lung cancer tumor microenvironment.
    CONCLUSIONS:
    The results of the present study suggest that prolonged exposure to BaP exacerbates lung cancer, particularly in female lung cancer patients with the BRAF mutation, but that laricitrin may ameliorate this effect.
    Oncotarget, 2016, 7(51):85220.
    Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3.[Reference: WebLink]
    Natural polyphenolic compounds of grapes and their seeds are thought to be therapeutic adjuvants in a variety of diseases, including cancer prevention. This study was carried out to investigate the effect of grape phenolic compounds on the regulation of cancer-mediated immune suppression.
    METHODS AND RESULTS:
    Laricitrin exhibits the greatest potential to ameliorate the suppressive effects of lung cancer on dendritic cells' (DCs') differentiation, maturation and function. Human lung cancer A549 and CL1-5 cells change the phenotype of DCs that express to high levels of IL-10 and prime T cells towards an immune suppression type-2 response (Th2). Laricitrin treatment stimulated DC differentiation and maturation in the condition media of cancer cells, a finding supported by monocyte marker CD14's disappearance and DC marker CD1a's upregulation. Laricitrin decreases expression of IL-10 in cancer-conditioned DCs, and subsequently switches CD4+ T cell response from Th2 to Th1 in vitro and in vivo. Reversal of laricitrin on lung cancer-induced DCs' paralysis was via inhibiting the phosphorylation of signal transducer and activator of transcription 3 (STAT3). Laricitrin also potentiated the anticancer activity of cisplatin in mouse models.
    CONCLUSIONS:
    Thus, laricitrin could be an efficacious immunoadjuvant and have a synergistic effect when combined with chemotherapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0093 mL 15.0466 mL 30.0933 mL 60.1866 mL 75.2332 mL
    5 mM 0.6019 mL 3.0093 mL 6.0187 mL 12.0373 mL 15.0466 mL
    10 mM 0.3009 mL 1.5047 mL 3.0093 mL 6.0187 mL 7.5233 mL
    50 mM 0.0602 mL 0.3009 mL 0.6019 mL 1.2037 mL 1.5047 mL
    100 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.6019 mL 0.7523 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二羟基-3',4',5'-三甲氧基黄烷酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavanone CFN70425 62252-10-2 C18H18O7 = 346.3 5mg QQ客服：1457312923
    3,5,7-三羟基-3',4',5'-三甲氧基黄酮; 3,5,7-Trihydroxy-3',4',5'-trimethoxyflavone CFN70275 146132-95-8 C18H16O8 = 360.3 5mg QQ客服：2056216494
    Combretol; Combretol CFN91118 5084-19-5 C20H20O8 = 388.4 10mg QQ客服：215959384
    5,7,3',4',5'-五甲氧基黄酮; 5,7,3',4',5'-Pentamethoxyflavone CFN91117 53350-26-8 C20H20O7 = 372.4 20mg QQ客服：2056216494
    8-羟基-3,5,7,3',4',5'-六甲氧基黄酮; 8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone CFN98025 202846-95-5 C21H22O9 = 418.4 5mg QQ客服：2159513211
    3',4',5',3,5,7,8-七甲氧基黄酮; 3',4',5',3,5,7,8-Heptamethoxyflavone CFN98076 21634-52-6 C22H24O9 = 432.4 5mg QQ客服：3257982914
    8-羟基-3,5,6,7,3',4'-六甲氧基黄酮; 8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone CFN90998 1000415-56-4 C21H22O9 = 418.39 5mg QQ客服：215959384
    Natsudaidain; Natsudaidain CFN91804 35154-55-3 C21H22O9 = 418.4 5mg QQ客服：1413575084
    3,3'',4'',5,5'',6,7-六甲氧基黄酮; 3',4',5',3,5,6,7-Heptamethoxyflavone CFN99812 17245-30-6 C22H24O9 = 432.4 5mg QQ客服：2159513211
    5,7-二羟基 3,3',4',5',6,8-六甲氧基黄酮; 5,7-Dihydroxy 3,3',4',5',6,8-hexamethoxyflavone CFN70469 96887-18-2 C21H22O10 = 434.4 5mg QQ客服：215959384

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