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  • Combretol

    • Combretol

    Combretol

    Combretol
    		产品编号 CFN91118
    CAS编号 5084-19-5
    分子式 = 分子量 C20H20O8 = 388.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The barks of Eucalyptus globulus Labill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Combretol CFN91118 5084-19-5 1mg QQ客服：2159513211
    Combretol CFN91118 5084-19-5 5mg QQ客服：2159513211
    Combretol CFN91118 5084-19-5 10mg QQ客服：2159513211
    Combretol CFN91118 5084-19-5 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Washington State University (USA)
  • University of Stirling (United Kingdom)
  • Shanghai University of TCM (China)
  • Mahatma Gandhi University (India)
  • Universidade Católica Portuguesa (Portugal)
  • University of Pretoria (South Africa)
  • University of Illinois (USA)
  • University of Oslo (Norway)
  • MTT Agrifood Research Finland (Finland)
  • Gyeongsang National University (Korea)
  • University of East Anglia (United Kingdom)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Otago (New Zealand)
  • Kyung Hee University (Korea)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2022, 291:115159.
  • Biomedicines.2021, 9(8):954.
  • LWT2020, 130:109535
  • Plant Methods.2017, 13:108
  • Phytomedicine.2015, 22(14):1262-8
  • Food Bioscience2022, 50:102187.
  • Biomed Pharmacother.2022, 146:112497.
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • Phytomedicine.2022, 99:153997.
  • Nat Prod Commun.2014, 9(5):679-82
  • Int Immunopharmacol.2019, 71:361-371
  • Metabolites2022, 12(6),507.
  • Trop J Nat Prod Res, February2023, 7(2):2371-2381
  • Nutrients.2018, 10(12)
  • Phytomedicine.2022, 96:153877.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Expert Opin Ther Targets.2024, :1-11.
  • Oncol Rep.2019, 41(4):2453-2463
  • Food Bioscience2023, 59:103903
  • Nutrients.2021, 13(12):4364.
  • Drug Des Devel Ther.2020, 14:61-71
  • Bioorg Med Chem.2020, 28(12):115553.
  • Inflammation.2021, doi: 10.1007
  • ...
    • 生物活性
    Description: Combretol has leishmanicidal activity, it showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 µM) against a multidrug-resistant L. tropica line. Combretol also shows weakly active cytotoxic activity.
    Targets: Antifection
    In vitro:
    Planta Med. 2011 Jan;77(1):77-80.
    Leishmanicidal and reversal multidrug resistance constituents from Aeonium lindleyi.[Pubmed: 20665372 ]

    METHODS AND RESULTS:
    A new bicyclic diterpene with a labdane skeleton, 7-oxo-labd-8-en-15-ol ( 1), along with two known diterpenes and ten flavonoids were isolated from the leaves of Aeonium lindleyi (Crassulaceae). Their structures were elucidated on the basis of spectroscopic data, including 1D and 2D NMR experiments, and comparison with spectroscopic data reported in the literature.
    CONCLUSIONS:
    Labdan-8 α,15-diol (2) and labd-8(17)-en-3 β,15-diol (3) showed leishmanicidal activity against Leishmania tropica (IC (50) = 77.0 µM) and Leishmania braziliensis (IC (50) = 68.0 µM) similar to ketoconazole used as positive control. 5,3'-Dihydroxy-3,7,4',5'-tetramethoxyflavone (8) and Combretol (9) showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 µM) against a multidrug-resistant L. tropica line.
    J Nat Prod. 2006 Feb;69(2):287-9.
    Cytotoxic diterpenes from Cassipourea madagascariensis from the Madagascar rainforest.[Pubmed: 16499334 ]

    METHODS AND RESULTS:
    Bioassay-directed fractionation of ethanol extracts of the roots and leaves of the plant Cassipourea madagascariensis resulted in the isolation of the two new terpenoids cassipourol (1) and cassipouryl acetate (2) in addition to the three known compounds, 3beta,30-dihydroxylup-20(29)-ene (3), 30-hydroxylup-20(29)-en-3-one (4), and combretol (5). The structures of the two new compounds were established on the basis of 1D and 2D NMR spectroscopic data and chemical conversion.
    CONCLUSIONS:
    All the isolated compounds were tested against the A2780 human ovarian cancer cell line; the two diterpenes (1 and 2) showed moderate cytotoxic activity, while the three known compounds (3-5) were weakly active.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5747 mL 12.8733 mL 25.7467 mL 51.4933 mL 64.3666 mL
    5 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    10 mM 0.2575 mL 1.2873 mL 2.5747 mL 5.1493 mL 6.4367 mL
    50 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.5149 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-羟基-3,5,7,3',4',5'-六甲氧基黄酮; 8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone CFN98025 202846-95-5 C21H22O9 = 418.4 5mg QQ客服：1413575084
    3',4',5',3,5,7,8-七甲氧基黄酮; 3',4',5',3,5,7,8-Heptamethoxyflavone CFN98076 21634-52-6 C22H24O9 = 432.4 5mg QQ客服：1457312923
    8-羟基-3,5,6,7,3',4'-六甲氧基黄酮; 8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone CFN90998 1000415-56-4 C21H22O9 = 418.39 5mg QQ客服：1457312923
    Natsudaidain; Natsudaidain CFN91804 35154-55-3 C21H22O9 = 418.4 5mg QQ客服：2159513211
    3,3'',4'',5,5'',6,7-六甲氧基黄酮; 3',4',5',3,5,6,7-Heptamethoxyflavone CFN99812 17245-30-6 C22H24O9 = 432.4 5mg QQ客服：3257982914
    5,7-二羟基 3,3',4',5',6,8-六甲氧基黄酮; 5,7-Dihydroxy 3,3',4',5',6,8-hexamethoxyflavone CFN70469 96887-18-2 C21H22O10 = 434.4 5mg QQ客服：215959384
    3,5,6,7,8,3',4',5'-八甲氧基黄酮; Exoticin CFN99417 13364-94-8 C23H26O10 = 462.5 5 mg QQ客服：2159513211
    粘毛黄芩素I; Viscidulin I CFN97489 92519-95-4 C15H10O7 = 302.2 5mg QQ客服：3257982914
    洋槐黄素; Robinetin CFN98780 490-31-3 C15H10O7 = 302.2 5mg QQ客服：3257982914
    杨梅素; Myricetin CFN98877 529-44-2 C15H10O8 = 318.2 20mg QQ客服：1413575084

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