2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮

KU55933 (ATM Kinase Inhibitor)

	产品编号	CFN60040
	CAS编号	587871-26-9
	分子式 = 分子量	C₂₁H₁₇NO₃S₂ = 395.49
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮	CFN60040	587871-26-9	1mg	QQ客服：3004468091
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮	CFN60040	587871-26-9	5mg	QQ客服：3004468091
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮	CFN60040	587871-26-9	10mg	QQ客服：3004468091
2-吗啉-4-基-6-噻蒽-1-基吡喃-4-酮	CFN60040	587871-26-9	20mg	QQ客服：3004468091

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Complutense University of Madrid (Spain)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Charles Sturt University (Denmark)

Regional Crop Research Institute (Korea)

University of Amsterdam (Netherlands)

Universite Libre de Bruxelles (Belgium)

Helmholtz Zentrum München (Germany)

Universidad Industrial de Santander (Colombia)

Center for protein Engineering (CIP) (Belgium)

Uniwersytet Jagielloński w Krakowie (Poland)

University of Hawaii Cancer Center (USA)

University of Hertfordshire (United Kingdom)

Vin?a Institute of Nuclear Sciences (Serbia)

S.N.D.T. Women's University (India)

More...

Description:

KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.

Targets:

ATM | Autophagy

In vivo:

Aging (Albany NY),2011 Aug;3(8):782-93.

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise.[Pubmed: 21869459]

The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood.
METHODS AND RESULTS:
We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft, and in vitro models to investigate the impact of chemotherapy-induced aging on the human ovary. Doxorubicin caused massive double-strand-DNA-breaks in primordial follicles, oocytes, and granulosa cells in a dose dependent fashion as revealed by accumulating γH2AX foci. This damage was associated with apoptotic oocyte death and resulted in the activation of ATM. It appeared that the repair response enabled a minor proportion of oocytes (34.7%) and granulosa cells (12.1%) to survive while the majority succumbed to apoptotic death. Paradoxically, inhibition of ATM by KU-55933 resulted in improved survival, probably via prevention of downstream activation of TAp63α. Furthermore, doxorubicin caused vascular and stromal damage in the human ovary, which might impair ovarian function both pre- and post-menopausally.
CONCLUSIONS:
Chemotherapy-induced premature ovarian aging appears to result from a complex process involving both the germ- and non-germ cell components of the ovary. These effects may have clinical implications in aging both for premenopausal and postmenopausal cancer survivors.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Jatairidoid A; Jatairidoid A	CFN95668	1393577-29-1	C₁₉H₂₈O₈ = 384.4	5mg	QQ客服：3004468088
大豆苷元; Daidzein	CFN98774	486-66-8	C₁₅H₁₀O₄ = 254.2	20mg	QQ客服：3004468088
尚含鸡纳苷; Quinovin	CFN99084	107870-05-3	C₃₆H₅₆O₉ = 632.8	5mg	QQ客服：3004468520
异牡荆黄素 2''-O-阿拉伯糖苷; Isovitexin 2''-O-arabinoside	CFN90943	53382-71-1	C₂₆H₂₈O₁₄ = 564.49	10mg	QQ客服：3004468091

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5285 mL	12.6425 mL	25.2851 mL	50.5702 mL	63.2127 mL
5 mM	0.5057 mL	2.5285 mL	5.057 mL	10.114 mL	12.6425 mL
10 mM	0.2529 mL	1.2643 mL	2.5285 mL	5.057 mL	6.3213 mL
50 mM	0.0506 mL	0.2529 mL	0.5057 mL	1.0114 mL	1.2643 mL
100 mM	0.0253 mL	0.1264 mL	0.2529 mL	0.5057 mL	0.6321 mL