芝麻林素

Sesamolin

	产品编号	CFN99799
	CAS编号	526-07-8
	分子式 = 分子量	C₂₀H₁₈O₇ = 370.36
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Lignans
	植物来源	The herbs of Justicia orbiculata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
芝麻林素	CFN99799	526-07-8	10mg	QQ客服：215959384
芝麻林素	CFN99799	526-07-8	20mg	QQ客服：215959384
芝麻林素	CFN99799	526-07-8	50mg	QQ客服：215959384
芝麻林素	CFN99799	526-07-8	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Eastern Finland (Finland)

National Cancer Center Research Institute (Japan)

Medical University of Gdansk (Poland)

Seoul National University (Korea)

University of Brasilia (Brazil)

The University of Newcastle (Australia)

University of Maryland School of Medicine (USA)

The Vancouver Prostate Centre (VPC) (Canada)

Harvard University (USA)

University of South Australia (Australia)

Regional Crop Research Institute (Korea)

Institute of Pathophysiology Medical University of Vienna (Austria)

Celltrion Chemical Research Institute (Korea)

Heinrich-Heine-University Düsseldorf (Germany)

More...

Description:

Sesaminol possesses antioxidative activity, can inhibit lipid peroxidation in rat liver and kidney. It also shows neuroprotection effect on hypoxic neuronal and PC12 cells through the suppression of ROS generation and MAPK activation.

Targets:

p38MAPK | Caspase | ERK | JNK | ROS

In vitro:

Int J Biomed Sci. 2006 Sep; 2(3): 284–8.

Neuroprotective Effects of Sesamin and Sesamolin on Gerbil Brain in Cerebral Ischemia[Pubmed: 23674992]

Sesamin and sesamolin, abundant lignans found in sesame oil, have been demonstrated to possess several bioactivities beneficial for human health.
METHODS AND RESULTS:
Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated when they were pretreated with sesamin or sesamolin. The neuroprotective effect of sesamin and sesamolin was also observed in vivo using gerbils subjected to a focal cerebral ischemia induced by occlusion of the right common carotid artery and the right middle cerebral artery. Repeated treatment of sesamin or a crude sesame oil extract containing both sesamin and sesamolin significantly reduced the infarct size, visualized via 2,3,5-triphenyltetrazolium chloride staining, by approximately 50% when compared with the control group.
CONCLUSIONS:
These results suggest that sesamin and sesamolin exert effective neuroprotection against cerbral ischemia.

In vivo:

Br J Nutr. 2007 Jan;97(1):85-95.

Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats.[Pubmed: 17217563]

Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats.
METHODS AND RESULTS:
Rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg) for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin. These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. In contrast, they decreased the activity and mRNA abundance of hepatic lipogenic enzymes despite dose-dependent effects not being necessarily obvious. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Sesamolin accumulated in serum at 33- and 46-fold the level of sesamin at dietary concentrations of 0.6 and 2 g/kg, respectively. The amount of sesamolin accumulated in liver was 10- and 7-fold that of sesamin at the respective dietary levels. Sesamolin rather than sesamin can account for the potent physiological effect of sesame seeds in increasing hepatic fatty acid oxidation observed previously. Differences in bioavailability may contribute to the divergent effects of sesamin and sesamolin on hepatic fatty acid oxidation.
CONCLUSIONS:
Sesamin compared to sesamolin was more effective in reducing serum and liver lipid levels despite sesamolin more strongly increasing hepatic fatty acid oxidation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Episesartemin A ; Episesartemin A	CFN96936	77449-31-1	C₂₃H₂₆O₈ = 430.45	5mg	QQ客服：2056216494
1-羟基松脂酚 1-O-beta-D-葡糖苷 ; 1-Hydroxypinoresinol 1-O-glucoside	CFN96713	81495-71-8	C₂₆H₃₂O₁₂ = 536.53	5mg	QQ客服：1413575084
Fraxiresinol 1-O-glucoside; Fraxiresinol 1-O-glucoside	CFN97460	89199-94-0	C₂₇H₃₄O₁₃ = 566.6	5mg	QQ客服：3257982914
辣薄荷醇; Piperitol	CFN96060	52151-92-5	C₂₀H₂₀O₆ = 356.4	5mg	QQ客服：1457312923
异戊烯基辣薄荷醇; Prenylpiperitol	CFN99668	157659-20-6	C₂₅H₂₈O₆ = 424.5	5mg	QQ客服：2159513211
Planispine A; Planispine A	CFN95348	1202761-42-9	C₂₆H₃₂O₆ = 440.5	10mg	QQ客服：2159513211
芝麻素; Sesamin	CFN97034	607-80-7	C₂₀H₁₈O₆ = 354.4	20mg	QQ客服：1413575084
泡桐素; Paulownin	CFN99394	13040-46-5	C₂₀H₁₈O₇ = 370.4	20mg	QQ客服：2159513211
Isoarboreol; Isoarboreol	CFN95716	N/A	C₂₀H₁₈O₈ = 386.4	5mg	QQ客服：1413575084
芝麻林素; Sesamolin	CFN99799	526-07-8	C₂₀H₁₈O₇ = 370.36	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7001 mL	13.5004 mL	27.0008 mL	54.0015 mL	67.5019 mL
5 mM	0.54 mL	2.7001 mL	5.4002 mL	10.8003 mL	13.5004 mL
10 mM	0.27 mL	1.35 mL	2.7001 mL	5.4002 mL	6.7502 mL
50 mM	0.054 mL	0.27 mL	0.54 mL	1.08 mL	1.35 mL
100 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.675 mL

芝麻林素

Sesamolin

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