
芝麻林素
Sesamolin
|
产品编号 |
CFN99799 |
CAS编号 |
526-07-8 |
分子式 = 分子量 |
C20H18O7 = 370.36 |
产品纯度 |
>=98% |
物理属性 |
White powder |
化合物类型 |
Lignans |
植物来源 |
The herbs of Justicia orbiculata |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
芝麻林素 |
CFN99799 |
526-07-8 |
10mg |
QQ客服:2056216494 |
芝麻林素 |
CFN99799 |
526-07-8 |
20mg |
QQ客服:2056216494 |
芝麻林素 |
CFN99799 |
526-07-8 |
50mg |
QQ客服:2056216494 |
芝麻林素 |
CFN99799 |
526-07-8 |
100mg |
QQ客服:2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
Texas A&M University (USA)
Lund University (Sweden)
University of South Australia (Australia)
Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
St. Jude Children Research Hospital (USA)
Yale University (USA)
Universitas Airlangga (Indonesia)
Universidade Federal de Pernambuco (UFPE) (Brazil)
University of Virginia (USA)
Universidad de Antioquia (Colombia)
University of Limpopo (South Africa)
Sanford Burnham Medical Research Institute (USA)
Uniwersytet Jagielloński w Krakowie (Poland)
Universit?t Basel (Switzerland)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Viruses2023, 15(6), 1377
PLoS One.2017, 12(8):e0181191
Research Square2023, 2883170.
Antioxidants2022, 11(2),234.
Biomed Pharmacother.2024, 173:116319.
Int J Mol Sci.2021, 22(21):11447.
Molecules.2017, 22(2)
J Mater Chem B.2019, 7(39):5896-5919
Description: |
Sesaminol possesses antioxidative activity, can inhibit lipid peroxidation in rat liver and kidney. It also shows neuroprotection effect on hypoxic neuronal and PC12 cells through the suppression of ROS generation and MAPK activation. |
Targets: |
p38MAPK | Caspase | ERK | JNK | ROS |
In vitro: |
Int J Biomed Sci. 2006 Sep; 2(3): 284–8. | Neuroprotective Effects of Sesamin and Sesamolin on Gerbil Brain in Cerebral Ischemia[Pubmed: 23674992] | Sesamin and sesamolin, abundant lignans found in sesame oil, have been demonstrated to possess several bioactivities beneficial for human health.
METHODS AND RESULTS:
Excess generation of nitric oxide in lipopolysaccharide-stimulated rat primary microglia cells was significantly attenuated when they were pretreated with sesamin or sesamolin. The neuroprotective effect of sesamin and sesamolin was also observed in vivo using gerbils subjected to a focal cerebral ischemia induced by occlusion of the right common carotid artery and the right middle cerebral artery. Repeated treatment of sesamin or a crude sesame oil extract containing both sesamin and sesamolin significantly reduced the infarct size, visualized via 2,3,5-triphenyltetrazolium chloride staining, by approximately 50% when compared with the control group.
CONCLUSIONS:
These results suggest that sesamin and sesamolin exert effective neuroprotection against cerbral ischemia. |
|
In vivo: |
Br J Nutr. 2007 Jan;97(1):85-95. | Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats.[Pubmed: 17217563] | Effects of sesamin and sesamolin (sesame lignans) on hepatic fatty acid metabolism were compared in rats.
METHODS AND RESULTS:
Rats were fed either a lignan-free diet, a diet containing 0.6 or 2 g/kg lignan (sesamin or sesamolin), or a diet containing both sesamin (1.4 g/kg) and sesamolin (0.6 g/kg) for 10 d. Sesamin and sesamolin dose-dependently increased the activity and mRNA abundance of various enzymes involved in hepatic fatty acid oxidation. The increase was much greater with sesamolin than with sesamin. These lignans increased parameters of hepatic fatty acid oxidation in an additive manner when added simultaneously to an experimental diet. In contrast, they decreased the activity and mRNA abundance of hepatic lipogenic enzymes despite dose-dependent effects not being necessarily obvious. Sesamin and sesamolin were equally effective in lowering parameters of lipogenesis. Sesamolin accumulated in serum at 33- and 46-fold the level of sesamin at dietary concentrations of 0.6 and 2 g/kg, respectively. The amount of sesamolin accumulated in liver was 10- and 7-fold that of sesamin at the respective dietary levels. Sesamolin rather than sesamin can account for the potent physiological effect of sesame seeds in increasing hepatic fatty acid oxidation observed previously. Differences in bioavailability may contribute to the divergent effects of sesamin and sesamolin on hepatic fatty acid oxidation.
CONCLUSIONS:
Sesamin compared to sesamolin was more effective in reducing serum and liver lipid levels despite sesamolin more strongly increasing hepatic fatty acid oxidation. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.7001 mL |
13.5004 mL |
27.0008 mL |
54.0015 mL |
67.5019 mL |
5 mM |
0.54 mL |
2.7001 mL |
5.4002 mL |
10.8003 mL |
13.5004 mL |
10 mM |
0.27 mL |
1.35 mL |
2.7001 mL |
5.4002 mL |
6.7502 mL |
50 mM |
0.054 mL |
0.27 mL |
0.54 mL |
1.08 mL |
1.35 mL |
100 mM |
0.027 mL |
0.135 mL |
0.27 mL |
0.54 mL |
0.675 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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