盐酸普拉克索

Pramipexole dihydrochloride

	产品编号	CFN90019
	CAS编号	104632-25-9
	分子式 = 分子量	C₁₀H₁₉Cl₂N₃S = 284.25
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
盐酸普拉克索	CFN90019	104632-25-9	1mg	QQ客服：215959384
盐酸普拉克索	CFN90019	104632-25-9	5mg	QQ客服：215959384
盐酸普拉克索	CFN90019	104632-25-9	10mg	QQ客服：215959384
盐酸普拉克索	CFN90019	104632-25-9	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Charles University in Prague (Czech Republic)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

University of Fribourg (Switzerland)

Shanghai Institute of Biochemistry and Cell Biology (China)

University of Maryland School of Medicine (USA)

Heidelberg University (Germany)

Siksha O Anusandhan University (India)

Ateneo de Manila University (Philippines)

University of Amsterdam (Netherlands)

Universitas Airlangga (Indonesia)

University of Zurich (Switzerland)

Medizinische Universit?t Wien (Austria)

Instituto de Investigaciones Agropecuarias (Chile)

University of Lodz (Poland)

More...

Description:

Pramipexole dihydrochloride could be used to treat Parkinson disease.

Targets:

Dopamine Receptor

In vivo:

Archives of Neurology [01 Jan 2010, 67(1):27-32]

Effects of a dopamine agonist on the pharmacodynamics of levodopa in Parkinson disease.[Pubmed: 20065126]

Treatment of Parkinson disease commonly includes levodopa and dopamine agonists; however, the interaction of these 2 drugs is poorly understood. To examine the effects of a dopamine agonist on the motor response to levodopa.
METHODS AND RESULTS:
Double-blind, randomized, placebo-controlled, crossover clinical trial. Ambulatory academic referral center. Patients Thirteen patients with idiopathic Parkinson disease taking levodopa and experiencing motor fluctuations and dyskinesia. Eligible individuals were randomly assigned to receive Pramipexole dihydrochloride or placebo for 4 weeks followed by a 2-hour intravenous levodopa infusion on consecutive days at 2 rates and with blinded assessments. They were then crossed over to the alternate oral therapy for 4 weeks followed by levodopa infusion and reassessment. Change in finger-tapping speed, measured using the area under the curve (AUC) for finger taps per minute across time; peak finger-tapping speed; duration of response; time to "ON" (defined as a 10% increase in finger-tapping speed above baseline); walking speed; and dyskinesia AUC. Pramipexole with levodopa infusion increased finger-tapping speed beyond the change in baseline by a mean (SE) of 170 (47.2) per minute x minutes (P = .006) and more than doubled the AUC for finger-tapping speed. Pramipexole increased peak finger-tapping speed by a mean (SE) of 18 (8.5) taps per minute (P = .02) and improved mean (SE) walking speed (15.9 [0.70] vs 18.9 [0.70] seconds, P = .004). Pramipexole prolonged duration of response after levodopa infusion and shortened time to ON. Pramipexole increased mean (SE) baseline dyskinesia scores (26.0 [5.85] vs 12.1 [5.85] points, P = .05) and peak dyskinesia scores with levodopa infusion.
CONCLUSIONS:
Pramipexole augmented the motor response to levodopa beyond a simple additive effect and increased the severity of levodopa-induced dyskinesia. When considering a combination of these therapies, an appropriate balance should be maintained regarding gain of motor function vs worsening of dyskinesia.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2-环己基乙胺; 2-Cyclohexylethylamine	CFN00069	4442-85-7	C₈H₁₇N = 127.23	5mg	QQ客服：1413575084
N-甲基环己烷乙胺; N-Methylcyclohexaneethaneamine	CFN00070	62141-38-2	C₉H₁₉N = 141.29	5mg	QQ客服：1413575084
3,3'-[Iminobis(methylene)]bis-2(3H)furanone; 3,3'-[Iminobis(methylene)]bis-2(3H)furanone	CFN00082	96562-86-6	C₁₀H₁₅NO₄ = 213.23	5mg	QQ客服：2056216494
Cassipourine; Cassipourine	CFN00442	14051-10-6	C₁₄H₂₂N₂S₄ = 346.60	5mg	QQ客服：215959384
酒石酸伐仑克林; Varenicline tartrate	CFN90008	375815-87-5	C₁₃H₁₃N₃.C₄H₆O₆ = 361.35	5mg	QQ客服：1457312923
盐酸帕洛诺司琼; Palonosetron hydrochloride	CFN90009	135729-62-3	C₁₉H₂₅ClN₂O = 332.87	20mg	QQ客服：2159513211
盐酸普拉克索; Pramipexole dihydrochloride	CFN90019	104632-25-9	C₁₀H₁₉Cl₂N₃S = 284.25	5mg	QQ客服：1413575084
雷美替胺; Ramelteon	CFN90021	166597-26-9	C₁₃H₂₁NO₂ = 259.34	5mg	QQ客服：1413575084
凝血酸，氨甲环酸; Tranexamic acid	CFN90569	1197-18-8	C₈H₁₅NO₂ = 157.21	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.518 mL	17.5901 mL	35.1803 mL	70.3606 mL	87.9507 mL
5 mM	0.7036 mL	3.518 mL	7.0361 mL	14.0721 mL	17.5901 mL
10 mM	0.3518 mL	1.759 mL	3.518 mL	7.0361 mL	8.7951 mL
50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.4072 mL	1.759 mL
100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.7036 mL	0.8795 mL