METHODS AND RESULTS:
All chemical structures were identified on the basis of electrospray ionization -mass spectrometry, one- and two-dimension nuclear magnetic resonance. Nine phenolic compounds, among them two new natural products ; isorhamnetin -3-O-β-D-glucuronyl (1′″→4″) glucuronide (1) and its dimethyl ester ; isorhamnetin -3-O-βD-di glucuronate dimethyl ester (2), two isorhamnetin glycosides : Isorhamnetin -3-O-β-D-galactopyranoside (3), isorhamnetin -3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic ; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distin ct anti -inflammatory activities with no toxicity on RAW 264.7 macrophage cells.
CONCLUSIONS:
Therfore, extract and the tested compounds showed distinct anti-inflammatory activities with no toxicity on RAW 264 so it may become targets for anti -inflammation drugs developmen. |
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
