覆盆子酮

4-(4-Hydroxyphenyl)-2-butanone

	产品编号	CFN90894
	CAS编号	5471-51-2
	分子式 = 分子量	C₁₀H₁₂O₂ = 164.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The rhizomes of Zingber officinale Rosc.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
覆盆子酮	CFN90894	5471-51-2	10mg	QQ客服：215959384
覆盆子酮	CFN90894	5471-51-2	20mg	QQ客服：215959384
覆盆子酮	CFN90894	5471-51-2	50mg	QQ客服：215959384
覆盆子酮	CFN90894	5471-51-2	100mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

4-(4-Hydroxyphenyl)-2-butanone(Raspberry ketone,RK) is widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff, it also shows PPAR-α agonistic activity. It is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical/occupational leukoderma.

Targets:

Tyrosinase

In vitro:

Chem Res Toxicol. 2017 Mar 20;30(3):859-868.

Tyrosinase-Catalyzed Oxidation of the Leukoderma-Inducing Agent Raspberry Ketone Produces (E)-4-(3-Oxo-1-butenyl)-1,2-benzoquinone: Implications for Melanocyte Toxicity.[Pubmed: 28219012]

The exposure of human skin to 4-(4-hydroxyphenyl)-2-butanone (raspberry ketone, RK) is known to cause chemical/occupational leukoderma. RK has a structure closely related to 4-(4-hydroxyphenyl)-2-butanol (rhododendrol), a skin whitening agent that was found to cause leukoderma in the skin of consumers in 2013. Rhododendrol is a good substrate for tyrosinase and causes a tyrosinase-dependent cytotoxicity to melanocytes, cells that are responsible for skin pigmentation.
METHODS AND RESULTS:
Therefore, it is expected that RK exerts its cytotoxicity to melanocytes through the tyrosinase-catalyzed oxidation to cytotoxic o-quinones. The results of this study demonstrate that the oxidation of RK by mushroom tyrosinase rapidly produces 4-(3-oxobutyl)-1,2-benzoquinone (RK-quinone), which is converted within 10-20 min to (E)-4-(3-oxo-1-butenyl)-1,2-benzoquinone (DBL-quinone). These quinones were identified as their corresponding catechols after reduction by ascorbic acid. RK-quinone and DBL-quinone quantitatively bind to the small thiol N-acetyl-l-cysteine to form thiol adducts and can also bind to the thiol protein bovine serum albumin through its cysteinyl residue. DBL-quinone is more reactive than RK-quinone, as judged by their half-lives (6.2 min vs 10.5 min, respectively), and decays rapidly to form an oligomeric pigment (RK-oligomer). The RK-oligomer can oxidize GSH to GSSG with a concomitant production of hydrogen peroxide, indicating its pro-oxidant activity, similar to that of the RD-oligomer.
CONCLUSIONS:
These results suggest that RK is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer.

In vivo:

Regul Toxicol Pharmacol. 2015 Oct;73(1):196-200.

Raspberry ketone in food supplements--High intake, few toxicity data--A cause for safety concern?[Pubmed: 26160596]

Raspberry ketone (4-(4-Hydroxyphenyl)-2-butanone) is marketed on the Internet as a food supplement. The recommended intake is between 100 and 1400 mg per day. The substance is naturally occurring in raspberries (up to 4.3 mg/kg) and is used as a flavouring substance.
METHODS AND RESULTS:
Toxicological studies on raspberry ketone are limited to acute and subchronic studies in rats. When the lowest recommended daily dose of raspberry ketone (100 mg) as a food supplement is consumed, it is 56 times the established threshold of toxicological concern (TTC) of 1800 μg/day for Class 1 substances. The margin of safety (MOS) based on a NOAEL of 280 mg/kg bw/day for lower weight gain in rats is 165 at 100 mg and 12 at 1400 mg. The recommended doses are a concern taking into account the TTC and MOS.
CONCLUSIONS:
Investigations of raspberry ketone in quantitative structure-activity relationship (QSAR) models indicated potential cardiotoxic effects and potential effects on reproduction/development. Taking into account the high intake via supplements, the compound's toxic potential should be clarified with further experimental studies. In UK the pure compound is regarded as novel food requiring authorisation prior to marketing but raspberry ketone is not withdrawn from Internet sites from this country.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
反式苯亚甲基丙酮; trans-4-phenylbut-3-en-2-one	CFN93101	1896-62-4	C₁₀H₁₀O = 146.2	20mg	QQ客服：1457312923
1-苯基-1,3-丁二酮; 1-Phenylbutane-1,3-dione	CFN93103	93-91-4	C₁₀H₁₀O₂ = 162.2	20mg	QQ客服：1413575084
覆盆子酮; 4-(4-Hydroxyphenyl)-2-butanone	CFN90894	5471-51-2	C₁₀H₁₂O₂ = 164.2	20mg	QQ客服：215959384
姜酮； 4-(4-羟基-3-甲氧基苯基)-2-丁酮; Zingerone	CFN99702	122-48-5	C₁₁H₁₄O₃ = 194.23	20mg	QQ客服：2056216494
Pseudolaroside A; Pseudolaroside A	CFN95740	885111-85-3	C₁₃H₁₆O₈ = 300.3	5mg	QQ客服：215959384
3,4-二羟基苯甲酸; 3,4-Dihydroxybenzoic acid	CFN97568	99-50-3	C₇H₆O₄ = 154.1	20mg	QQ客服：3257982914
3,4-二羟基苯甲酸甲酯; Protocatechuic acid methyl ester	CFN92634	2150-43-8	C₈H₈O₄ = 168.2	20mg	QQ客服：1457312923
3-羟基-4-甲氧基苯甲酸，异香兰酸; Isovanillic acid	CFN92419	645-08-9	C₈H₈O₅ = 168.1	20mg	QQ客服：1413575084
异香兰酸甲酯; Methyl isovanillate	CFN92984	6702-50-7	C₉H₁₀O₄ = 182.17	20mg	QQ客服：3257982914
香草酸; Vanillic acid	CFN99331	121-34-6	C₈H₈O₄ = 168.2	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0901 mL	30.4507 mL	60.9013 mL	121.8027 mL	152.2533 mL
5 mM	1.218 mL	6.0901 mL	12.1803 mL	24.3605 mL	30.4507 mL
10 mM	0.609 mL	3.0451 mL	6.0901 mL	12.1803 mL	15.2253 mL
50 mM	0.1218 mL	0.609 mL	1.218 mL	2.4361 mL	3.0451 mL
100 mM	0.0609 mL	0.3045 mL	0.609 mL	1.218 mL	1.5225 mL

覆盆子酮

4-(4-Hydroxyphenyl)-2-butanone

信息支持

联系方式