高香草酸

Homovanillic acid

	产品编号	CFN99763
	CAS编号	306-08-1
	分子式 = 分子量	C₉H₁₀O₄ = 182.17
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The barks of Ilex rotunda Thunb.
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产品名称	产品编号	CAS编号	包装	QQ客服
高香草酸	CFN99763	306-08-1	10mg	QQ客服：1413575084
高香草酸	CFN99763	306-08-1	20mg	QQ客服：1413575084
高香草酸	CFN99763	306-08-1	50mg	QQ客服：1413575084
高香草酸	CFN99763	306-08-1	100mg	QQ客服：1413575084

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Description:

Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain. Abnormalities in white matter were associated with low CSF Homovanillic acid.

In vitro:

Clin Chim Acta. 2013 Sep 23;424:253-7.

Analysis of vanillylmandelic acid and homovanillic acid by UPLC-MS/MS in serum for diagnostic testing for neuroblastoma.[Pubmed: 23830883]

Vanillylmandelic acid (VMA) and Homovanillic acid (HVA) are typically measured in urine for the diagnosis and monitoring of neuroblastoma, a tumor in children <5 y. A protocol for evaluation of serum VMA and Homovanillic acid has been utilized at our institution for approximately 25 y, originally validated using high performance liquid chromatography (HPLC) with an electrochemical detector. We recently validated a serum VMA/HVA method by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).
METHODS AND RESULTS:
After solvent extraction and clean up with Ultrafree centrifugal filters, samples were analyzed by UPLC-MS/MS in multiple reaction monitoring mode. The assay was linear between 2 and 1000 ng/ml for VMA and Homovanillic acid . Within run and run to run CVs were <5% for VMA at all levels, <10% for HVA at high levels, and <20% at low levels. Correlation with the HPLC method was acceptable with a constant bias. The reference interval for VMA by UPLC-MS/MS was determined to be ≤20 ng/ml, and HVA≤30 ng/ml. Original patient data comparing urine to serum showed diagnostic agreement >80% for both VMA and Homovanillic acid .
CONCLUSIONS:
Correlation of VMA and Homovanillic acid was acceptable after adjustment of reference intervals. Collection of a single serum sample instead of 24-h urine collection saves time and improves accuracy of measurement due to difficulty of collecting a 24-h urine sample in infants and young children. UPLC-MS/MS also offers improved analyte specificity, improved signal to noise, and rapid analysis time.

In vivo:

Dev Med Child Neurol. 2013 Jun;55(6):559-66.

Homovanillic acid in cerebrospinal fluid of 1388 children with neurological disorders.[Pubmed: 23480488]

To determine the prevalence of dopaminergic abnormalities in 1388 children with neurological disorders, and to analyse their clinical, neuroradiological, and electrophysiological characteristics.
METHODS AND RESULTS:
We studied biogenic amines in 1388 cerebrospinal fluid (CSF) samples from children with neurological disorders (mean age 3y 10mo, SD 4y 5mo; 712 males, 676 females. Correlations among CSF Homovanillic acid (HVA) values and other biochemical, clinical, neuroradiological, and electrophysiological parameters were analysed. Twenty-one patients with primary dopaminergic deficiencies were identified. Of the whole sample, 20% showed altered Homovanillic acid. We report neurological diseases with abnormal CSF Homovanillic acid values such as pontocerebellar hypoplasia, perinatal asphyxia, central nervous system infections, mitochondrial disorders, and other genetic diseases. Overlapping Homovanillic acid levels between primary and secondary dopamine deficiencies were observed. Prevalence of low CSF Homovanillic acid levels was significantly higher in neonatal patients (χ(2) =84.8, p<0.001). Abnormalities in white matter were associated with low CSF Homovanillic acid (odds ratio 2.3, 95% confidence interval 1.5-3.5).
CONCLUSIONS:
HVA abnormalities are observed in various neurological diseases, but some are probably an unspecific finding. No clear limits for CSF Homovanillic acid values pointing towards primary diseases can be stated. We report several neurological diseases showing Homovanillic acid alterations. No neuroimaging traits were associated with low Homovanillic acid values, except for white matter abnormalities.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
香草酸甲酯; Methyl vanillate	CFN91546	3943-74-6	C₉H₁₀O₄ = 182.2	20mg	QQ客服：3257982914
香草酸4-O-beta-D-葡萄糖苷; Vanillic acid glucoside	CFN95257	32142-31-7	C₁₄H₁₈O₉ = 330.3	5mg	QQ客服：215959384
香草酸乙酯; Ethyl vanillate	CFN92765	617-05-0	C₁₀H₁₂O₇ = 196.2	20mg	QQ客服：1457312923
3,4-二甲氧基苯甲酸; 3,4-Dimethoxybenzoic acid	CFN97499	93-07-2	C₉H₁₀O₄ = 182.2	20mg	QQ客服：2056216494
2,5-二羟基苯甲酸; Gentisic acid	CFN92451	490-79-9	C₇H₆O₄ = 154.1	20mg	QQ客服：1457312923
Orsellinic acid; Orsellinic acid	CFN96277	480-64-8	C₈H₈O₄ = 168.2	5mg	QQ客服：1457312923
3-甲基-4-硝基苯甲酸; 3-Methyl-4-nitrobenzoic acid	CFN90115	3113-71-1	C₈H₇NO₄ = 181.15	5mg	QQ客服：2159513211
3,4-二羟基苯乙酮; 3',4'-Dihydroxyacetophenone	CFN97903	1197-09-7	C₈H₈O₃ = 152.2	20mg	QQ客服：1413575084
香草醇; Vanillyl alcohol	CFN93211	498-00-0	C₈H₁₀O₃ = 154.17	20mg	QQ客服：1413575084
3,4-二羟基苯乙醇; 2-(3,4-Dihydroxyphenyl)ethanol	CFN99076	10597-60-1	C₈H₁₀O₃ = 154.2	20mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	109.7876 mL	137.2345 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	21.9575 mL	27.4469 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	10.9788 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	2.1958 mL	2.7447 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.0979 mL	1.3723 mL

高香草酸

Homovanillic acid

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