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  • 异鼠李素-3-葡萄糖醛酸苷

    • 异鼠李素-3-葡萄糖醛酸苷

    Isorhamnetin 3-glucuronide

    异鼠李素-3-葡萄糖醛酸苷
    		产品编号 CFN90568
    CAS编号 36687-76-0
    分子式 = 分子量 C22H20O13 = 492.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Potentilla discolor Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异鼠李素-3-葡萄糖醛酸苷 CFN90568 36687-76-0 1mg QQ客服：2056216494
    异鼠李素-3-葡萄糖醛酸苷 CFN90568 36687-76-0 5mg QQ客服：2056216494
    异鼠李素-3-葡萄糖醛酸苷 CFN90568 36687-76-0 10mg QQ客服：2056216494
    异鼠李素-3-葡萄糖醛酸苷 CFN90568 36687-76-0 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Canterbury (New Zealand)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2018, 23(9):E2121
  • Appl. Sci.2021, 11(1),14.
  • Nutrients.2020, 12(12):3638.
  • Int J Mol Sci.2022, 23(21):13112.
  • Regen Biomater.2023, 10:rbad077.
  • Asian J Beauty Cosmetol2022, 20(2):183-191
  • Food Funct.2022, 13(23):12105-12120.
  • Appl. Sci.2023, 13(17):9984.
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Separations2023, 10(7), 411.
  • J Nat Med.2018, 72(3):734-744
  • FEBS J.2022, 10.1111:febs.16676.
  • Food Chem.2023, 404(Pt A):134517.
  • Toxicol Res.2019, 35(4):371-387
  • ACS Pharmacol Transl Sci.2024, 7(2):395-405.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Molecules.2024, 29(3):671.
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Univerzita Karlova2022, 173245.
  • Free Radic Biol Med.2017, 112:191-199
  • Food Analytical Methods2020, 1-10
  • Nat Commun.2019, 10(1):5169
  • Free Radic Biol Med.2016, 97:307-319
  • ...
    • 生物活性
    Description: Isorhamnetin 3 -O -glucuronide exerts anti-inflammatory activity by increasing heme oxygenase-1 (HO-1) expression and by suppressing Jun N-terminal kinase (JNK) and p38 signaling pathways in LPS-challenged RAW264.7 macrophage cells. Isorhamnetin 3-glucuronide can inhibit vascular cell adhesion molecule-1 (VCAM-1) cell surface expression at 2 micromol/L, indicates that it can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis at physiological concentrations. It (1 mg/kg i.v.) can progressively reduce mean blood pressure (MBP), measured in conscious spontaneously hypertensive rats (SHR).
    Targets: HO-1 | JNK | p38MAPK
    In vivo:
    Plos One, 2012, 7(3):e32673.
    Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.[Pubmed: 22427863 ]

    METHODS AND RESULTS:
    We have analyzed the effects on blood pressure and vascular function in vitro of the conjugated metabolites of quercetin (quercetin-3-glucuronide, Q3GA; Isorhamnetin 3-glucuronide, I3GA; and quercetin-3'-sulfate, Q3'S) in spontaneously hypertensive rats (SHR). Q3GA and I3GA (1 mg/kg i.v.), but not Q3'S, progressively reduced mean blood pressure (MBP), measured in conscious SHR. The hypotensive effect of Q3GA was abolished in SHR treated with the specific inhibitor of β-glucuronidase, saccharic acid 1,4-lactone (SAL, 10 mg/ml). In mesenteric arteries, unlike quercetin, Q3GA had no inhibitory effect in the contractile response to phenylephrine after 30 min of incubation. However, after 1 hour of incubation Q3GA strongly reduced this contractile response and this effect was prevented by SAL. Oral administration of quercetin (10 mg/Kg) induced a progressive decrease in MBP, which was also suppressed by SAL. Conjugated metabolites are involved in the in vivo antihypertensive effect of quercetin, acting as molecules for the plasmatic transport of quercetin to the target tissues.
    CONCLUSIONS:
    Quercetin released from its glucuronidated metabolites could be responsible for its vasorelaxant and hypotensive effect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0309 mL 10.1546 mL 20.3091 mL 40.6182 mL 50.7728 mL
    5 mM 0.4062 mL 2.0309 mL 4.0618 mL 8.1236 mL 10.1546 mL
    10 mM 0.2031 mL 1.0155 mL 2.0309 mL 4.0618 mL 5.0773 mL
    50 mM 0.0406 mL 0.2031 mL 0.4062 mL 0.8124 mL 1.0155 mL
    100 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.4062 mL 0.5077 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    商陆苷; Ombuoside CFN92808 20188-85-6 C29H34O16 = 638.6 5mg QQ客服：1457312923
    柽柳黄素 7-O-新橙皮糖苷; Tamarixetin 7-O-neohesperidoside CFN91527 28283-76-3 C28H32O16 = 624.6 5mg QQ客服：3257982914
    异鼠李素-7-O-葡萄糖苷; Isorhamnetin 7-O-glucoside CFN91115 6743-96-0 C22H22O12 = 478.4 5mg QQ客服：2159513211
    异鼠李素-3-O-葡萄糖-7-O-鼠李糖苷; Isorhamnetin 3-glucoside-7-rhamnoside CFN90739 17331-71-4 C28H32O16 = 624.54 5mg QQ客服：3257982914
    异鼠李素-3,7-O-二葡萄糖苷; Isorhamnetin 3,7-O-diglucoside CFN91130 6758-51-6 C28H32O17 = 640.6 5mg QQ客服：2159513211
    异鼠李素-3-O-芸香苷-7-O-葡萄糖苷; Isorhamnetin-3-O-rutinoside-7-O-glucoside CFN95494 55481-91-9 C34H42O21 = 786.7 5mg QQ客服：2056216494
    异鼠李素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷; Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside CFN91845 60778-00-9 C34H42O22 = 802.7 5mg QQ客服：1413575084
    异鼠李素-3-O-槐二糖-7-O-鼠李糖苷; Isorhamnetin 3-sophoroside-7-rhamnoside CFN90735 41328-75-0 C34H42O21 = 786.68 5mg QQ客服：1457312923
    柠檬黄素-3-O-β-D-葡萄糖苷; Limocitrin 3-O-beta-D-glucopyranoside CFN91697 38836-51-0 C23H24O13 = 508.4 5mg QQ客服：1457312923
    柠檬黄素-3-O-芸香糖苷; Limocitrin-3-O-rutinoside CFN91693 79384-27-3 C29H34O17 = 654.6 5mg QQ客服：2159513211

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