异奥卡宁

Isookanin

	产品编号	CFN90850
	CAS编号	1036-49-3
	分子式 = 分子量	C₁₅H₁₂O₆ = 288.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Bidens pilosa
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异奥卡宁	CFN90850	1036-49-3	10mg	QQ客服：2159513211
异奥卡宁	CFN90850	1036-49-3	20mg	QQ客服：2159513211
异奥卡宁	CFN90850	1036-49-3	50mg	QQ客服：2159513211
异奥卡宁	CFN90850	1036-49-3	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with the IC50 value of 7.9 ± 0.53 uM. Isookanin is a potent inhibitor of α-amylase (IC₅₀=0.447 mg/ml).

In vitro:

J Agric Food Chem. 2015 Jan 14;63(1):200-7.

New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i-converting enzyme inhibitory activities.[Pubmed: 25516207 ]

Three new phenolic compounds, coretinphenol (1), coretincone (2), and coretinphencone (3), were isolated from the buds of Coreopsis tinctoria Nutt., together with nine known compounds, including butein (4), okanin (5), isoliquiritigenin (6), maritimetin (7), taxifolin (8), Isookanin (9), marein (10), sachalinoside B (11), and 2-phenylethyl-β-d-glucoside (12).
METHODS AND RESULTS:
The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of compounds 1–3, 6, 7, 9, 11, and 12 from C. tinctoria. Compounds 5–9 showed strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity, with IC50 values of 3.35 ± 0.45, 9.6 ± 2.32, 4.12 ± 0.21, 6.2 ± 0.43, and 7.9 ± 0.53 μM, respectively. Compounds 2 and 8 exhibited angiotensin I-converting enzyme inhibitory activity, with IC50 values of 228 ± 4.47 and 145.67 ± 3.45 μM, respectively.
CONCLUSIONS:
The activities of phenolic compounds isolated from C. tinctoria support the medicinal use of this plant in the prevention of cardiovascular diseases.

In vivo:

Molecules . 2020 Jun 5;25(11):2631.

Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice[Pubmed: 32517000]

Abstract This study investigated the leaves of Clinacanthus nutans for its bioactive compounds and acute and subacute toxicity effects of C. nutans ethanolic leaf extract (CELE) on blood, liver and kidneys of ICR mice. A total of 10 8-week-old female mice were divided into groups A (control) and B (2000 mg/kg) for the acute toxicity study. A single dose of 2000 mg/kg was administered to group B through oral gavage and mice were monitored for 14 days. In the subacute toxicity study, mice were divided into five groups: A (control), B (125 mg/kg), C (250 mg/kg), D (500 mg/kg) and E (1000 mg/kg). The extract was administered daily for 28 days via oral gavage. The mice were sacrificed, and samples were collected for analyses. Myricetin, orientin, isoorientin, vitexin, isovitexin, isookanin, apigenin and ferulic acid were identified in the extract. Twenty-eight days of continuous oral administration revealed significant increases (p < 0.05) in creatinine, ALT and moderate hepatic and renal necrosis in groups D and E. The study concluded that the lethal dose (LD50) of CELE in mice is greater than 2000 mg/kg and that repeated oral administrations of CELE for 28 days induced hepatic and renal toxicities at 1000 mg/kg in female ICR mice. Keywords: Clinacanthus nutans; ICR mice; acute toxicity; biochemical parameters; histopathology; isookanin; myricetin; orientin; subacute toxicity; vitexin.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
圣草酚; Eriodictyol	CFN99719	552-58-9	C₁₅H₁₂O₆ = 288.25	20mg	QQ客服：2159513211
7-O-甲基圣草酚; 7-O-Methyleriodictyol	CFN98833	51857-11-5	C₁₆H₁₄O₆ = 302.3	5mg	QQ客服：3257982914
高圣草素; Homoeriodictyol	CFN96489	446-71-9	C₁₆H₁₄O₆ = 302.28	5mg	QQ客服：1457312923
槲寄生新甙III; Viscumneoside III	CFN89421	118985-27-6	C₂₇H₃₂O₁₅ = 596.53	10mg	QQ客服：1457312923
圣草酚 7,3'-二甲醚; Eriodictyol 7,3'-dimethyl ether	CFN89533	54352-60-2	C₁₇H₁₆O₆ = 316.30	5mg	QQ客服：2159513211
橙皮素; Hesperetin	CFN98842	520-33-2	C₁₆H₁₄O₆ = 302.3	20mg	QQ客服：1413575084
橙皮素-7-甲醚; Hesperetin-7-methyl ether	CFN90876	N/A	C₁₇H₁₆O₆ = 316.3	10mg	QQ客服：1413575084
圣草酚 7,3',4'-三甲醚; 7,3',4'-Tri-O-methyleriodictyol	CFN89491	70987-96-1	C₁₈H₁₈O₆ = 330.33	5mg	QQ客服：3257982914
(2S)-5,7,3'4'-四甲氧基二氢黄酮; (2S)-5,7,3',4'-tetramethoxyflavanone	CFN95406	74628-43-6	C₁₉H₂₀O₆ = 344.4	10mg	QQ客服：1457312923
5,6,7,3',4'-五甲氧基二氢黄酮; 5,6,7,3',4'-Pentamethoxyflavanone	CFN95394	104193-93-3	C₂₀H₂₂O₇ = 374.4	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4686 mL	17.343 mL	34.6861 mL	69.3722 mL	86.7152 mL
5 mM	0.6937 mL	3.4686 mL	6.9372 mL	13.8744 mL	17.343 mL
10 mM	0.3469 mL	1.7343 mL	3.4686 mL	6.9372 mL	8.6715 mL
50 mM	0.0694 mL	0.3469 mL	0.6937 mL	1.3874 mL	1.7343 mL
100 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.6937 mL	0.8672 mL

异奥卡宁

Isookanin

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