Info: Read More
  • 中药标准品生产商,产品定制服务
  • 黄诺马苷

    Flavanomarein

    黄诺马苷
    产品编号 CFN91006
    CAS编号 577-38-8
    分子式 = 分子量 C21H22O11 = 450.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Laurentia atropurpurea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄诺马苷 CFN91006 577-38-8 1mg QQ客服:2159513211
    黄诺马苷 CFN91006 577-38-8 5mg QQ客服:2159513211
    黄诺马苷 CFN91006 577-38-8 10mg QQ客服:2159513211
    黄诺马苷 CFN91006 577-38-8 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Agricultural Research Organization (ARO) (Israel)
  • Center for protein Engineering (CIP) (Belgium)
  • National Cancer Institute (USA)
  • University of Hawaii Cancer Center (USA)
  • Cornell University (USA)
  • Universidad de Buenos Aires (Argentina)
  • Monash University (Australia)
  • Universiti Sains Malaysia (Malaysia)
  • University of Hertfordshire (United Kingdom)
  • Uniwersytet Gdański (Poland)
  • Gyeongsang National University (Korea)
  • University of Stirling (United Kingdom)
  • Mendel University in Brno (Czech Republic)
  • Hamdard University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2020, 43(5):1716-1728.
  • Molecules.2019, 24(9):E1719
  • Bulletin of Health Research2016, 44(4):279-286
  • Earth Environ. Sci. 2021, 905:012080.
  • VNU Journal of Science2023, 39(2):24-33.
  • Korean J of Pharmacognosy2020, 51,49-54.
  • J Ethnopharmacol.2017, 198:205-213
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Pak J Pharm Sci.2019, 32(6)
  • Biomed Chromatogr.2019, 8:e4774
  • Agronomy2020, 10(10),1489
  • Molecules.2020, 25(11):2599.
  • Industrial Crops and Products2020, 146:112186
  • J Ethnopharmacol.2016, 194:219-227
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Planta Med.2018, 84(15):1101-1109
  • Int J Mol Sci.2022, 23(23):14826.
  • Toxicol In Vitro.2023, 86:105521.
  • Int J Mol Sci.2019, 20(9):E2244
  • Food and Fermentation Industries2019, 45(7):45-51
  • J Ethnopharmacol.2020, 269:113752.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • ...
  • 生物活性
    Description: Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid‑lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs).
    In vitro:
    Mol Med Rep. 2017 Aug;16(2):1298-1306.
    Eriodictyol 7‑O‑β‑D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.[Pubmed: 28627652]
    Coreopsis tinctoria (snow chrysanthemum) has been reported to exert antihyperlipidemic effects.
    METHODS AND RESULTS:
    The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as Flavanomarein (compound 1) and eriodictyol 7‑O‑β‑D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid‑lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA‑treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide‑isomerase A3 precursor and fatty acid synthase, thus suppressing FFA‑induced lipogenesis in HepG2 cells.
    CONCLUSIONS:
    In conclusion, the present study identified compound 2 as one of the main active compounds in Coreopsis tinctoria responsible for its lipid‑lowering effects. Compound 2 was revealed to possess antihyperlipidemic properties, exerted via reducing oxidative stress, protecting mitochondrial function and suppressing lipogenesis.
    Acta Pol Pharm. 2007 Sep-Oct;64(5):441-7.
    Antioxidant activity of extracts and flavonoids from Bidens tripartita.[Pubmed: 18540165]
    Extracts from herb and flowers of Bidens tripartita L. (Asteraceae), obtained using solvents of different polarity, were studied for their radical scavenging effects.
    METHODS AND RESULTS:
    Antioxidant activities of pure flavonoids: Flavanomarein (isookanin 7-O-glucoside), cynaroside (luteolin 7-O-glucoside) and luteolin, which had been isolated from this plant, were also evaluated. Radical-scavenging activity was measured by electron paramagnetic resonance (EPR) spectroscopy using stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The content of flavonoids in flower heads is half of that found in the herb; however, the extract from flowers showed that the antioxidant activity was almost two times higher there. Some extracts (n-BuOH fraction) showed long lasting radical scavenging activity and the EPR spectra were recorded in time to follow the reaction kinetics.
    CONCLUSIONS:
    Scavenging of DPPH showed second-order kinetics at the beginning of the assay period and later the first-order one. Different kinetics suggested the presence of polymerized and/or less active antioxidants with different scavenging mechanisms for particular polyphenolic compounds. Bur-marigold extracts are a potential source of natural antioxidants that may be used in pharmaceutical or food industry.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2202 mL 11.1012 mL 22.2025 mL 44.405 mL 55.5062 mL
    5 mM 0.444 mL 2.2202 mL 4.4405 mL 8.881 mL 11.1012 mL
    10 mM 0.222 mL 1.1101 mL 2.2202 mL 4.4405 mL 5.5506 mL
    50 mM 0.0444 mL 0.222 mL 0.444 mL 0.8881 mL 1.1101 mL
    100 mM 0.0222 mL 0.111 mL 0.222 mL 0.444 mL 0.5551 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高圣草素; Homoeriodictyol CFN96489 446-71-9 C16H14O6 = 302.28 5mg QQ客服:1457312923
    槲寄生新甙III; Viscumneoside III CFN89421 118985-27-6 C27H32O15 = 596.53 10mg QQ客服:215959384
    圣草酚 7,3'-二甲醚; Eriodictyol 7,3'-dimethyl ether CFN89533 54352-60-2 C17H16O6 = 316.30 5mg QQ客服:3257982914
    橙皮素; Hesperetin CFN98842 520-33-2 C16H14O6 = 302.3 20mg QQ客服:2056216494
    橙皮素-7-甲醚; Hesperetin-7-methyl ether CFN90876 N/A C17H16O6 = 316.3 10mg QQ客服:1413575084
    圣草酚 7,3',4'-三甲醚; 7,3',4'-Tri-O-methyleriodictyol CFN89491 70987-96-1 C18H18O6 = 330.33 5mg QQ客服:2159513211
    (2S)-5,7,3'4'-四甲氧基二氢黄酮; (2S)-5,7,3',4'-tetramethoxyflavanone CFN95406 74628-43-6 C19H20O6 = 344.4 10mg QQ客服:2159513211
    5,6,7,3',4'-五甲氧基二氢黄酮; 5,6,7,3',4'-Pentamethoxyflavanone CFN95394 104193-93-3 C20H22O7 = 374.4 5mg QQ客服:215959384
    异奥卡宁; Isookanin CFN90850 1036-49-3 C15H12O6 = 288.3 20mg QQ客服:1413575084
    黄诺马苷; Flavanomarein CFN91006 577-38-8 C21H22O11 = 450.4 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产