异橙皮内酯
Isomeranzin
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 异橙皮内酯 |
CFN99090 |
1088-17-1 |
10mg |
QQ客服：2056216494 |
| 异橙皮内酯 |
CFN99090 |
1088-17-1 |
20mg |
QQ客服：2056216494 |
| 异橙皮内酯 |
CFN99090 |
1088-17-1 |
50mg |
QQ客服：2056216494 |
| 异橙皮内酯 |
CFN99090 |
1088-17-1 |
100mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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FORTH-IMBB (Greece)
The Institute of Cancer Research (United Kingdom)
Medical University of Gdansk (Poland)
Florida A&M University (USA)
Universita' Degli Studi Di Cagliari (Italy)
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University of Zurich (Switzerland)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Universiti Putra Malaysia(UPM) (Malaysia)
Institute of Pathophysiology Medical University of Vienna (Austria)
Lund University (Sweden)
Uniwersytet Medyczny w ?odzi (Poland)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway. |
| Targets: |
NF-kB | ERK |
| In vivo: |
| Int Immunopharmacol. 2016 Sep;38:175-85. | | Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.[Pubmed: 27285671 ] | Macrophage polarization plays an important role in inflammation. Regulation of the polarization has been reported to be effective therapeutics for various kinds of inflammatory diseases. The aims of the present study were to investigate the anti-inflammatory property of isomeranzin isolating from Murraya exotica as well as potential molecular mechanisms.
METHODS AND RESULTS:
Results showed that isomeranzin specifically reduced the M1 macrophage-associated pro-inflammatory cytokines through down-regulation of NF-κB and ERK signals. Immunoprecipitation and RNA silencing indicated suppression of isomeranzin in NF-κB activation was relying on the decreasing of TRAF6 ubiquitination. In vivo studies showed isomeranzin evidently inhibited LPS-induced sepsis for rising survival rate, improving tissue damage and lessening inflammatory cytokines. In accordance with in vitro studies, isomeranzin significantly blocked expression of p-p65 and p-ERK in lung and liver tissues. Moreover, isomeranzin ameliorated DSS and TNBS-induced colitis due to its anti-inflammatory effects.
CONCLUSIONS:
Taken together, isomeranzin suppressed inflammatory diseases by controlling M1 macrophage polarization through the NF-κB and ERK pathway. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.8417 mL |
19.2086 mL |
38.4172 mL |
76.8344 mL |
96.043 mL |
| 5 mM |
0.7683 mL |
3.8417 mL |
7.6834 mL |
15.3669 mL |
19.2086 mL |
| 10 mM |
0.3842 mL |
1.9209 mL |
3.8417 mL |
7.6834 mL |
9.6043 mL |
| 50 mM |
0.0768 mL |
0.3842 mL |
0.7683 mL |
1.5367 mL |
1.9209 mL |
| 100 mM |
0.0384 mL |
0.1921 mL |
0.3842 mL |
0.7683 mL |
0.9604 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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