| In vitro: |
| Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3594-7. | | Studies on coumarins from fruit of Cnidium monnieri and their cytotoxic activities.[Pubmed: 26983206] | This study is to study is to investigate the coumarins from Fruit of Cnidium monnieri and their cytotoxic activities.
METHODS AND RESULTS:
The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytoxic activities by MTT method. Eleven compounds were isolated and identified as osthole (1), bergaptan (2), xanthotoxol (3), xanthotoxin (4), imperatorin (5), isopimpinellin (6), osthenol (7), psoralen (8), 5,7-dimethoxycoumarin (9), oxypeucedaninhydrate (10), and swietenocoumarin F (11). Compounds 7, 9-11 were isolated from the Cnidium genus for the first time.
CONCLUSIONS:
Compounds 1,5,10 and 11 showed significant cytotoxic activities against L1210 cell lines at a concentration of 1 x 10(-5) mol x L(-1) with inhibitory rates of were 70.13, 63.10, 55.77, and 75.08% respectively. | | Z Naturforsch C. 2008 Jan-Feb;63(1-2):21-8. | | Antifungal activity of coumarins.[Pubmed: 18386483 ] |
METHODS AND RESULTS:
The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method.
CONCLUSIONS:
Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 microg/ml for Fusarium solani and 250 micro/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position. | | Z Naturforsch C. 2005 Sep-Oct;60(9-10):693-700. | | Antibacterial activity of coumarins.[Pubmed: 16320610 ] |
METHODS AND RESULTS:
The antibacterial activity of coumarin per se and other 45 coumarin derivatives was tested against strains of Bacillus cereus MIP 96016, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus ATCC 25923. The inhibitory effects of coumarins were affected by their substitution patterns. Osthenol (44) showed the most effective antibacterial activity against Gram-positive bacteria with MIC values ranging between 125 and 62.5 microg/ml.
CONCLUSIONS:
These results suggested that the prenyl chain of 44 at position 8 and the presence of OH at position 7 of the benzenic ring are required for the antibacterial activity against these strains. |
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