| In vitro: |
| Antiviral Res. 1999 Sep;43(2):79-92. | | Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1.[Pubmed: 10517310] | Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1).
METHODS AND RESULTS:
First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption. Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines. Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data: (1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol, a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation. | | J Econ Entomol. 2003 Aug;96(4):1267-74. | | Repellent effects of isoborneol on subterranean termites (Isoptera: Rhinotermitidae) in soils of different composition[Pubmed: 14503600] |
METHODS AND RESULTS:
The repellence of the plant-derived bicyclic monoterpenoid isoborneol on subterranean termites was assessed in short-term laboratory bioassays. Depending on concentration, application of isoborneol to different soil types was efficient in creating repellent soil barriers, which were not penetrated by workers of Reticulitermes santonensis De Feytaud or R. flavipes Kollar within 2 wk after adding the substance to the substrate. Isoborneol-treated barriers did not affect termite survival. The bioavailability of the active ingredient decreased with increasing clay content of the soil.
CONCLUSIONS:
Evaporation of isoborneol from treated soil increased with increasing particle size of the substrate and could be reduced by covering the soil surface. |
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