欧前胡素

Imperatorin

	产品编号	CFN98758
	CAS编号	482-44-0
	分子式 = 分子量	C₁₆H₁₄O₄ = 270.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica dahurica Benth. et Hook.
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产品名称	产品编号	CAS编号	包装	QQ客服
欧前胡素	CFN98758	482-44-0	10mg	QQ客服：1413575084
欧前胡素	CFN98758	482-44-0	20mg	QQ客服：1413575084
欧前胡素	CFN98758	482-44-0	50mg	QQ客服：1413575084
欧前胡素	CFN98758	482-44-0	100mg	QQ客服：1413575084

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Description:

Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol); it is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Imperatorin is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. Imperatorin has anticonvulsant, anti-inflammatory, anti-oxidant, neuroprotection, and anti-cancer effects, it also has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. Imperatorin dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC), and blocks the HSP27 and HSP72 gene expression.

Targets:

In vitro:

Biomol Ther (Seoul). 2015 Sep; 23(5): 421–427.

Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells.[Pubmed: 26336581]

Imperatorin has been known to exert many biological functions including anti-inflammatory activity.
METHODS AND RESULTS:
In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and the generation of eicosanoids (leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)) in IgE/antigen (Ag)-stimulated BMMC. To elucidate the molecular mechanism involved in this process, we investigated the effect of imperatorin on intracellular signaling in BMMC. Biochemical analyses of the IgE/Ag-mediated signaling pathway demonstrated that imperatorin dramatically attenuated degranulation and the production of 5-lipoxygenase-dependent LTC4 and cyclooxygenase-2-dependent PGD2 through the inhibition of intracellular calcium influx/phospholipase Cγ1, cytosolic phospholipase A2/mitogen-activated protein kinases and/or nuclear factor-κB pathways in BMMC.
CONCLUSIONS:
These results suggest that the effects of imperatorin on inhibition of degranulation and eicosanoid generation through the suppression of multiple steps of IgE/Ag-mediated signaling pathways would be beneficial for the prevention of allergic inflammation.

Oncol Rep. 2016 Apr;35(4):1995-2002.

Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade.[Pubmed: 26794238 ]

Despite advances in medical treatments for colon cancer, it remains one of the leading causes of cancer-related mortality among men. Thus, more efficacious treatment strategies for colon cancer are needed. Imperatorin is one of the major ingredients present in the root of Angelica dahurica, and has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. However, the medical properties of imperatorin remain unclear.
METHODS AND RESULTS:
In the present study, the anti‑proliferative activities of imperatorin were investigated in the HT‑29 colon cancer cell line. The results showed that imperatorin significantly inhibited HT‑29 colon cancer cell growth with an IC50 value of 78 μM. Imperatorin induced the apoptosis of colon cancer cells through upregulation of p53 and the caspase cascade. Our findings revealed that imperatorin induced cell cycle arrest in the G1 phase. The apoptotic index showed a steady increment when the imperatorin concentration was increased.
CONCLUSIONS:
The results suggest that imperatorin exerts considerable anti‑proliferative activities in HT‑29 colon cancer cells and highlight the potential of imperatorin as an anticancer agent for colon cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
欧前胡素; Imperatorin	CFN98758	482-44-0	C₁₆H₁₄O₄ = 270.3	20mg	QQ客服：215959384
独活素; Heraclenin	CFN98354	2880-49-1	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：1413575084
异栓翅芹醇; Isogosferol	CFN98890	53319-52-1	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：215959384
异石当归素; Isosaxalin	CFN98929	55481-86-2	C₁₆H₁₅ClO₅ = 322.7	5mg	QQ客服：3257982914
白芷属脑; Heraclenol	CFN98402	31575-93-6	C₁₆H₁₆O₆ = 304.3	10mg	QQ客服：2056216494
(-)-白藏属脑; (-)-Heraclenol	CFN89405	139079-42-8	C₁₆H₁₆O₆ = 304.29	5mg	QQ客服：1457312923
独活属醇缩丙酮; Heraclenol acetonide	CFN97112	64790-68-7	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：1413575084
3'-O-BETA-D-吡喃葡萄糖苷白芷属脑酯; Heraclenol 3'-O-beta-D-glucopyranoside	CFN98410	32207-10-6	C₂₂H₂₆O₁₁ = 466.4	5mg	QQ客服：215959384
Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]; Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]	CFN97243	765316-44-7	C₂₇H₃₄O₁₅ = 598.6	5mg	QQ客服：3257982914
Rivulobirin E; Rivulobirin E	CFN98247	237407-59-9	C₃₂H₃₀O₁₁ = 590.6	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6996 mL	18.498 mL	36.9959 mL	73.9919 mL	92.4898 mL
5 mM	0.7399 mL	3.6996 mL	7.3992 mL	14.7984 mL	18.498 mL
10 mM	0.37 mL	1.8498 mL	3.6996 mL	7.3992 mL	9.249 mL
50 mM	0.074 mL	0.37 mL	0.7399 mL	1.4798 mL	1.8498 mL
100 mM	0.037 mL	0.185 mL	0.37 mL	0.7399 mL	0.9249 mL

欧前胡素

Imperatorin

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