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  • 欧前胡素

    Imperatorin

    欧前胡素
    产品编号 CFN98758
    CAS编号 482-44-0
    分子式 = 分子量 C16H14O4 = 270.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica Benth. et Hook.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    欧前胡素 CFN98758 482-44-0 10mg QQ客服:2159513211
    欧前胡素 CFN98758 482-44-0 20mg QQ客服:2159513211
    欧前胡素 CFN98758 482-44-0 50mg QQ客服:2159513211
    欧前胡素 CFN98758 482-44-0 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Deutsches Krebsforschungszentrum (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Beira Interior (Portugal)
  • University of Virginia (USA)
  • Periyar University (India)
  • Charles Sturt University (Denmark)
  • Sanford Burnham Medical Research Institute (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Sapienza University of Rome (Italy)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Medicine and Pharmacy (Romania)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Colorado State University (USA)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2018, 23(7):E1817
  • Cancer Lett. 2023, 18:216584.
  • Planta Med.2023, a-2192-2281.
  • Biomed Pharmacother.2022, 156:113929.
  • Phytother Res.2015, 29(7):1088-96
  • J-STAGE2015, 249-255
  • J Ethnopharmacol.2023, 317:116789.
  • Kasetsart University2022, ethesis.1144.
  • Molecules.2018, 23(7):E1659
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Microchemical Journal2023. 191:108938
  • Journal of Apicultural Research2021, 60(1)
  • Foods.2022, 11(12):1773.
  • Scientific World Journal.2014, 2014:654193
  • Viruses2023, 15(6), 1377
  • Pharmaceutics2022, 14(2),376.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Analytical sci. & Tech2020, 33(5):224-231
  • Metab Eng.2022, 75:143-152.
  • J Chromatogr A.2017, 1518:46-58
  • ACS Omega2020, 5,33,20825-20830
  • Acta Physiologiae Plantarum2016, 38:7
  • ...
  • 生物活性
    Description: Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol); it is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Imperatorin is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. Imperatorin has anticonvulsant, anti-inflammatory, anti-oxidant, neuroprotection, and anti-cancer effects, it also has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. Imperatorin dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC), and blocks the HSP27 and HSP72 gene expression.
    Targets: COX | Caspase | HSP (e.g. HSP90) | Sodium Channel | Potassium Channel | Bcl-2/Bax | PPAR | NOS | BChE | TRPV1
    In vitro:
    Biomol Ther (Seoul). 2015 Sep; 23(5): 421–427.
    Imperatorin Suppresses Degranulation and Eicosanoid Generation in Activated Bone Marrow-Derived Mast Cells.[Pubmed: 26336581]
    Imperatorin has been known to exert many biological functions including anti-inflammatory activity.
    METHODS AND RESULTS:
    In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and the generation of eicosanoids (leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)) in IgE/antigen (Ag)-stimulated BMMC. To elucidate the molecular mechanism involved in this process, we investigated the effect of imperatorin on intracellular signaling in BMMC. Biochemical analyses of the IgE/Ag-mediated signaling pathway demonstrated that imperatorin dramatically attenuated degranulation and the production of 5-lipoxygenase-dependent LTC4 and cyclooxygenase-2-dependent PGD2 through the inhibition of intracellular calcium influx/phospholipase Cγ1, cytosolic phospholipase A2/mitogen-activated protein kinases and/or nuclear factor-κB pathways in BMMC.
    CONCLUSIONS:
    These results suggest that the effects of imperatorin on inhibition of degranulation and eicosanoid generation through the suppression of multiple steps of IgE/Ag-mediated signaling pathways would be beneficial for the prevention of allergic inflammation.
    Oncol Rep. 2016 Apr;35(4):1995-2002.
    Imperatorin exhibits anticancer activities in human colon cancer cells via the caspase cascade.[Pubmed: 26794238 ]
    Despite advances in medical treatments for colon cancer, it remains one of the leading causes of cancer-related mortality among men. Thus, more efficacious treatment strategies for colon cancer are needed. Imperatorin is one of the major ingredients present in the root of Angelica dahurica, and has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. However, the medical properties of imperatorin remain unclear.
    METHODS AND RESULTS:
    In the present study, the anti‑proliferative activities of imperatorin were investigated in the HT‑29 colon cancer cell line. The results showed that imperatorin significantly inhibited HT‑29 colon cancer cell growth with an IC50 value of 78 μM. Imperatorin induced the apoptosis of colon cancer cells through upregulation of p53 and the caspase cascade. Our findings revealed that imperatorin induced cell cycle arrest in the G1 phase. The apoptotic index showed a steady increment when the imperatorin concentration was increased.
    CONCLUSIONS:
    The results suggest that imperatorin exerts considerable anti‑proliferative activities in HT‑29 colon cancer cells and highlight the potential of imperatorin as an anticancer agent for colon cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
    5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
    10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
    50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    欧前胡素; Imperatorin CFN98758 482-44-0 C16H14O4 = 270.3 20mg QQ客服:1413575084
    独活素; Heraclenin CFN98354 2880-49-1 C16H14O5 = 286.3 5mg QQ客服:1413575084
    异栓翅芹醇; Isogosferol CFN98890 53319-52-1 C16H14O5 = 286.3 5mg QQ客服:215959384
    异石当归素; Isosaxalin CFN98929 55481-86-2 C16H15ClO5 = 322.7 5mg QQ客服:1457312923
    白芷属脑; Heraclenol CFN98402 31575-93-6 C16H16O6 = 304.3 10mg QQ客服:2159513211
    (-)-白藏属脑; (-)-Heraclenol CFN89405 139079-42-8 C16H16O6 = 304.29 5mg QQ客服:3257982914
    独活属醇缩丙酮; Heraclenol acetonide CFN97112 64790-68-7 C19H20O6 = 344.4 5mg QQ客服:215959384
    3'-O-BETA-D-吡喃葡萄糖苷白芷属脑酯; Heraclenol 3'-O-beta-D-glucopyranoside CFN98410 32207-10-6 C22H26O11 = 466.4 5mg QQ客服:1457312923
    Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]; Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] CFN97243 765316-44-7 C27H34O15 = 598.6 5mg QQ客服:1413575084
    Rivulobirin E; Rivulobirin E CFN98247 237407-59-9 C32H30O11 = 590.6 5mg QQ客服:1413575084

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