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  • 白芷属脑

    Heraclenol

    白芷属脑
    产品编号 CFN98402
    CAS编号 31575-93-6
    分子式 = 分子量 C16H16O6 = 304.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Heracleum repula Franch.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白芷属脑 CFN98402 31575-93-6 1mg QQ客服:215959384
    白芷属脑 CFN98402 31575-93-6 5mg QQ客服:215959384
    白芷属脑 CFN98402 31575-93-6 10mg QQ客服:215959384
    白芷属脑 CFN98402 31575-93-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Chung Hsing University (Taiwan)
  • Agricultural Research Organization (ARO) (Israel)
  • Stanford University (USA)
  • Monash University Malaysia (Malaysia)
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  • The Ohio State University (USA)
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  • Technical University of Denmark (Denmark)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • J Food Biochem.2019, 43(9):e12970
  • Int J Mol Sci.2018, 19(9):E2825
  • Biomed Pharmacother.2023, 163:114785.
  • Vet World.2023, 16(3):618-630.
  • Plant Physiol Biochem.2019, 144:355-364
  • Indian J. of Experimental Bio.2020, 9(58).
  • Int J Mol Sci.2022, 23(11):6104.
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Molecules.2021, 26(9):2765.
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • Food Research International2020, 108987
  • Journal of Analytical Chemistry2017, 854-861
  • LWT2020, 126:109313
  • J Pharm Anal.2016, 6(6):363-373
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Pharmaceutics.2021, 13(7):1028.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):21-39.
  • Ecol Evol.2022, 12(11):e9459.
  • Int J Mol Sci.2020, 21(9):3144.
  • ...
  • 生物活性
    Description: Heraclenol is a germination inhibitor in the parsley seeds. It has anti-inflammatory properties against the ear edema in mice produced by TPA. Heraclenol and heraclenin inhibit the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 uM.
    Targets: Immunology & Inflammation related
    In vitro:
    Phytochemistry,1978,17(1):158-9.
    The coumarin heraclenol as a growth inhibitor in parsley seeds.[Reference: WebLink]

    METHODS AND RESULTS:
    By the aid of germination assay with lettuce seeds, the germination inhibitors in the parsley seeds were investigated. One of the inhibitors was revealed to be heraclenol.
    In vivo:
    Planta Med. 2000 Apr;66(3):279-81.
    Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model.[Pubmed: 10821059]

    METHODS AND RESULTS:
    From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1-6 were examined against the ear edema in mice produced by TPA.
    CONCLUSIONS:
    The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.
    Photochem Photobiol. 2013 Sep-Oct;89(5):1216-25.
    In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umbelliferae medicinal plants, in melanoma cells.[Pubmed: 23802687]

    METHODS AND RESULTS:
    We examined the effects of six furocoumarins with alkoxy groups at the C-5 or C-8 position isolated from Umbelliferae medicinal plants on cell proliferation, and their mechanisms of action against B16F10 melanoma cells or in melanin-possessing hairless mice implanted with B16F10 cells, under UVA irradiation. Three furocoumarins with an alkoxy group at C-5, isoimperatorin (1), oxypeucedanin (2) and oxypeucedanin hydrate (3), showed antiproliferative activity and caused G2/M arrest at concentrations of 0.1-10.0 μm. Furthermore, three furocoumarins with an alkoxy group at C-8, imperatorin (4), heraclenin (5) and heraclenol (6), inhibited the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 μm. UVA plus 1, 2, 3, 4 and 6 reduced tumor growth and final tumor weight in B16F10-bearing mice at a dose of 0.3, 0.5 or 1.0 mg kg(-1) (intraperitoneal injection). UVA plus 1, 3 and 6 increased Chk1 phosphorylation and reduced cdc2 (Thr 161) phosphorylation in melanoma cells.
    CONCLUSIONS:
    We suggest that the antitumor actions of UVA plus furocoumarins with an alkoxy group at C-5 or C-8 were due to G2/M arrest of the cell cycle by an increase in phosphor-Chk1 and decrease in phospho-cdc2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2862 mL 16.4312 mL 32.8623 mL 65.7246 mL 82.1558 mL
    5 mM 0.6572 mL 3.2862 mL 6.5725 mL 13.1449 mL 16.4312 mL
    10 mM 0.3286 mL 1.6431 mL 3.2862 mL 6.5725 mL 8.2156 mL
    50 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.3145 mL 1.6431 mL
    100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6572 mL 0.8216 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    欧前胡素; Imperatorin CFN98758 482-44-0 C16H14O4 = 270.3 20mg QQ客服:1457312923
    独活素; Heraclenin CFN98354 2880-49-1 C16H14O5 = 286.3 5mg QQ客服:2159513211
    异栓翅芹醇; Isogosferol CFN98890 53319-52-1 C16H14O5 = 286.3 5mg QQ客服:1413575084
    异石当归素; Isosaxalin CFN98929 55481-86-2 C16H15ClO5 = 322.7 5mg QQ客服:3257982914
    白芷属脑; Heraclenol CFN98402 31575-93-6 C16H16O6 = 304.3 10mg QQ客服:2056216494
    (-)-白藏属脑; (-)-Heraclenol CFN89405 139079-42-8 C16H16O6 = 304.29 5mg QQ客服:3257982914
    独活属醇缩丙酮; Heraclenol acetonide CFN97112 64790-68-7 C19H20O6 = 344.4 5mg QQ客服:1457312923
    3'-O-BETA-D-吡喃葡萄糖苷白芷属脑酯; Heraclenol 3'-O-beta-D-glucopyranoside CFN98410 32207-10-6 C22H26O11 = 466.4 5mg QQ客服:2056216494
    Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside]; Heraclenol 3'-O-[beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside] CFN97243 765316-44-7 C27H34O15 = 598.6 5mg QQ客服:215959384
    Rivulobirin E; Rivulobirin E CFN98247 237407-59-9 C32H30O11 = 590.6 5mg QQ客服:3257982914

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