Hyperxanthone E

	产品编号	CFN91900
	CAS编号	819860-76-9
	分子式 = 分子量	C₁₈H₁₆O₆ = 328.32
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Garcinia mangostana
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Hyperxanthone E	CFN91900	819860-76-9	1mg	QQ客服：3257982914
Hyperxanthone E	CFN91900	819860-76-9	5mg	QQ客服：3257982914
Hyperxanthone E	CFN91900	819860-76-9	10mg	QQ客服：3257982914
Hyperxanthone E	CFN91900	819860-76-9	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
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PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Seoul National University of Science and Technology (Korea)

Johannes Gutenberg University Mainz (JGU) (Germany)

Florida A&M University (USA)

Korea Institute of Oriental Medicine (Korea)

Seoul National University (Korea)

Universidade da Beira Interior (Germany)

Stanford University (USA)

University of East Anglia (United Kingdom)

Cornell University (USA)

Universitas Airlangga (Indonesia)

Amity University (India)

Kamphaengphet Rajabhat University (Thailand)

Istanbul University (Turkey)

University of the Basque Country (Spain)

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Description:

Hyperxanthone E is a phytoalexin from Hypericum calycinum cell cultures.

In vitro:

Plant Physiol. 2012 Nov;160(3):1267-80.

Cinnamate:CoA ligase initiates the biosynthesis of a benzoate-derived xanthone phytoalexin in Hypericum calycinum cell cultures.[Pubmed: 22992510]

Although a number of plant natural products are derived from benzoic acid, the biosynthesis of this structurally simple precursor is poorly understood. Hypericum calycinum cell cultures accumulate a benzoic acid-derived xanthone phytoalexin, Hyperxanthone E, in response to elicitor treatment.
METHODS AND RESULTS:
Using a subtracted complementary DNA (cDNA) library and sequence information about conserved coenzyme A (CoA) ligase motifs, a cDNA encoding cinnamate:CoA ligase (CNL) was isolated. This enzyme channels metabolic flux from the general phenylpropanoid pathway into benzenoid metabolism. HcCNL preferred cinnamic acid as a substrate but failed to activate benzoic acid. Enzyme activity was strictly dependent on the presence of Mg2⁺ and K⁺ at optimum concentrations of 2.5 and 100 mM, respectively. Coordinated increases in the Phe ammonia-lyase and HcCNL transcript levels preceded the accumulation of Hyperxanthone E in cell cultures of H. calycinum after the addition of the elicitor. HcCNL contained a carboxyl-terminal type 1 peroxisomal targeting signal made up by the tripeptide Ser-Arg-Leu, which directed an amino-terminal reporter fusion to the peroxisomes.
CONCLUSIONS:
Masking the targeting signal by carboxyl-terminal reporter fusion led to cytoplasmic localization. A phylogenetic tree consisted of two evolutionarily distinct clusters. One cluster was formed by CoA ligases related to benzenoid metabolism, including HcCNL. The other cluster comprised 4-coumarate:CoA ligases from spermatophytes, ferns, and mosses, indicating divergence of the two clades prior to the divergence of the higher plant lineages.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0458 mL	15.229 mL	30.4581 mL	60.9162 mL	76.1452 mL
5 mM	0.6092 mL	3.0458 mL	6.0916 mL	12.1832 mL	15.229 mL
10 mM	0.3046 mL	1.5229 mL	3.0458 mL	6.0916 mL	7.6145 mL
50 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2183 mL	1.5229 mL
100 mM	0.0305 mL	0.1523 mL	0.3046 mL	0.6092 mL	0.7615 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one; 1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one	CFN92541	1319198-98-5	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：2056216494
6-脱氧巴西红厚壳素; 6-Deoxyjacareubin	CFN96276	16265-56-8	C₁₈H₁₄O₅ = 310.3	5mg	QQ客服：1413575084
1,3,7-三羟基-2-异戊烯基氧杂蒽酮; 1,3,7-Trihydroxy-2-prenylxanthone	CFN98022	20245-39-0	C₁₈H₁₆O₅ = 312.3	5mg	QQ客服：2159513211
1,7-二羟基-3-甲氧基-2-异戊烯基氧杂蒽酮; 1,7-Dihydroxy-3-methoxy-2-prenylxanthone	CFN97264	77741-58-3	C₁₉H₁₈O₅ = 326.4	5mg	QQ客服：2056216494
1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮; 1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone	CFN99202	110187-11-6	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：3257982914
1,4,5,6-四羟基-7-苯基氧蒽酮; 1,4,5,6-Tetrahydroxy-7-prenylxanthone	CFN99016	1001424-68-5	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：2159513211
1,4,6-三羟基-5-甲氧基-7-异戊二烯基呫吨酮; 1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone	CFN99675	160623-47-2	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：3257982914
7,9,12-三羟基-2,2-二甲基-2H,6H-吡喃并[3,2-b]氧杂蒽-6-酮; O-Demethylforbexanthone	CFN97493	92609-77-3	C₁₈H₁₄O₆ = 326.3	5mg	QQ客服：2159513211
Hyperxanthone E; Hyperxanthone E	CFN91900	819860-76-9	C₁₈H₁₆O₆ = 328.32	5mg	QQ客服：215959384
3,4-二氢-7,10-二羟基-12-甲氧基-2,2-二甲基-2H,6H-吡喃并[3,2-b]氧杂蒽-6-酮; Garcinexanthone A	CFN99206	1107620-67-6	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：2056216494