1,3,5-三羟基-4-异戊烯基氧杂蒽酮

1,3,5-Trihydroxy-4-prenylxanthone

	产品编号	CFN98891
	CAS编号	53377-61-0
	分子式 = 分子量	C₁₈H₁₆O₅ = 312.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Xanthones
	植物来源	The herbs of Cudrania tricuspidata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
1,3,5-三羟基-4-异戊烯基氧杂蒽酮	CFN98891	53377-61-0	1mg	QQ客服：215959384
1,3,5-三羟基-4-异戊烯基氧杂蒽酮	CFN98891	53377-61-0	5mg	QQ客服：215959384
1,3,5-三羟基-4-异戊烯基氧杂蒽酮	CFN98891	53377-61-0	10mg	QQ客服：215959384
1,3,5-三羟基-4-异戊烯基氧杂蒽酮	CFN98891	53377-61-0	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Leipzig (Germany)

Imperial College London (United Kingdom)

St. Jude Children Research Hospital (USA)

Subang Jaya Medical Centre (Malaysia)

Nanjing University of Chinese Medicine (China)

Uniwersytet Gdański (Poland)

Worcester Polytechnic Institute (USA)

University of Madras (India)

Universitas Airlangga (Indonesia)

Colorado State University (USA)

Max-Planck-Insitut (Germany)

Tokyo Woman's Christian University (Japan)

Macau University of Science and Technology (China)

Universidade da Beira Interior (Germany)

More...

Description:

1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction.

Targets:

NF-kB | IkB | AP-1 | JNK | ERK | TGF-β/Smad | AChR | IKK | BChR | AChR | PDE | IRAK-1 | TAK

In vitro:

Nat Prod Commun. 2015 Feb;10(2):301-3.

Phosphodiesterase inhibitory activity of the flavonoids and xanthones from Anaxagorea luzonensis.[Pubmed: 25920267]

METHODS AND RESULTS:
Five flavonoids, one isoflavone and five xanthones were isolated from Anaxagorea luzonensis. Of these eleven isolated compounds, 1,3,5-Trihydroxy-4-prenylxanthone (3) was a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM.
CONCLUSIONS:
This is the first report showing that natural xanthones can exhibit promising PDE5 inhibitory activity. Moreover, this study revealed that the presence of the C-4 prenyl residue attached to the xanthone core is correlated with the significant PDE5 inhibitory activity.

Journal of Medicinal Plant Research, 2012 , 6 (21):3781-3785.

Cholinesterase inhibitory activities of xanthones from Anaxagorea luzonensis A. Gray[Reference: WebLink]

METHODS AND RESULTS:
Five xanthones (1-5) were isolated from the heartwood of Anaxagorea luzonensis A. Gray (Annonaceae) and this is the first report of the isolation of xanthone 1 (6-deoxyisojacareubin) from this species. The in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) of these isolated xanthones was highest in 1,3,5-Trihydroxy-4-prenylxanthone (3) for both enzymes with IC50 values of 56.3±0.4 and 46.0±0.3 μM, respectively.
CONCLUSIONS:
The presence of the C-4 prenyl residue attached to the xanthone core co-orrelated significantly with the AChE and BChE inhibitory activities and was significantly reduced by hydroxylation (removal of the carbon double bond and addition of a hydroxyl group).

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
6-Deoxyisojacareubin; 6-Deoxyisojacareubin	CFN89446	26486-92-0	C₁₈H₁₄O₅ = 310.30	5mg	QQ客服：3257982914
Ugaxanthone; Ugaxanthone	CFN96469	13179-11-8	C₁₈H₁₆O₆ = 328.32	5mg	QQ客服：215959384
异巴西红厚壳素 ; Isojacareubin	CFN96573	50597-93-8	C₁₈H₁₄O₆ = 326.31	5mg	QQ客服：215959384
1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one; 1,3,6,8-tetrahydroxy-4-(3-methyl-2-buten-1-yl)-9H-Xanthen-9-one	CFN92541	1319198-98-5	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：3257982914
6-脱氧巴西红厚壳素; 6-Deoxyjacareubin	CFN96276	16265-56-8	C₁₈H₁₄O₅ = 310.3	5mg	QQ客服：215959384
1,3,7-三羟基-2-异戊烯基氧杂蒽酮; 1,3,7-Trihydroxy-2-prenylxanthone	CFN98022	20245-39-0	C₁₈H₁₆O₅ = 312.3	5mg	QQ客服：3257982914
1,7-二羟基-3-甲氧基-2-异戊烯基氧杂蒽酮; 1,7-Dihydroxy-3-methoxy-2-prenylxanthone	CFN97264	77741-58-3	C₁₉H₁₈O₅ = 326.4	5mg	QQ客服：3257982914
1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮; 1,5,8-Trihydroxy-3-methoxy-2-prenylxanthone	CFN99202	110187-11-6	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：2056216494
1,4,5,6-四羟基-7-苯基氧蒽酮; 1,4,5,6-Tetrahydroxy-7-prenylxanthone	CFN99016	1001424-68-5	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：3257982914
1,4,6-三羟基-5-甲氧基-7-异戊二烯基呫吨酮; 1,4,6-Trihydroxy-5-methoxy-7-prenylxanthone	CFN99675	160623-47-2	C₁₉H₁₈O₆ = 342.4	5mg	QQ客服：3257982914

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.202 mL	16.0102 mL	32.0205 mL	64.041 mL	80.0512 mL
5 mM	0.6404 mL	3.202 mL	6.4041 mL	12.8082 mL	16.0102 mL
10 mM	0.3202 mL	1.601 mL	3.202 mL	6.4041 mL	8.0051 mL
50 mM	0.064 mL	0.3202 mL	0.6404 mL	1.2808 mL	1.601 mL
100 mM	0.032 mL	0.1601 mL	0.3202 mL	0.6404 mL	0.8005 mL