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  • 氢化可的松

    Hydrocortisone

    氢化可的松
    产品编号 CFN90033
    CAS编号 50-23-7
    分子式 = 分子量 C21H30O5 = 362.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 From a simple carbon source by recombinant Saccharomyces cerevisiae strains.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    氢化可的松 CFN90033 50-23-7 10mg QQ客服:1457312923
    氢化可的松 CFN90033 50-23-7 20mg QQ客服:1457312923
    氢化可的松 CFN90033 50-23-7 50mg QQ客服:1457312923
    氢化可的松 CFN90033 50-23-7 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Universidade da Beira Interior (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Stirling (United Kingdom)
  • University of Bordeaux (France)
  • Seoul National University (Korea)
  • China Medical University (Taiwan)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of South Australia (Australia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Shanghai University of TCM (China)
  • Stanford University (USA)
  • Donald Danforth Plant Science Center (USA)
  • Uniwersytet Gdański (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Planta Med.2023, a-2192-2281.
  • Free Radic Biol Med.2016, 97:307-319
  • Inflammation.2015, 38(4):1502-16
  • Nutrients.2020, 12(5):1242.
  • Front Pharmacol.2021, 12:652860.
  • Pharmacological Reports2020, 1-9
  • Oncotarget.2016, 8(51):88386-88400
  • Anal Biochem.2019, 569:10-15
  • Antioxidants (Basel).2021, 10(9):1487.
  • Toxicol Res.2019, 35(4):371-387
  • JOTCSA.2023, 10(4); 893-902.
  • Chem Biol Interact.2022, 368:110248.
  • Front Cell Dev Biol.2021, 9:638174.
  • Molecules.2018, 23(9):E2121
  • Food Chem.2021, 360:130063.
  • Plant Physiol Biochem.2021, 160:166-174.
  • Molecules 2022, 27(3),1047.
  • Molecules.2016, 21(10)
  • J Nat Prod.2022, 85(5):1351-1362.
  • J Pharm Biomed Anal.2019, 164:119-127
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Int J Mol Sci.2019, 20(9):E2244
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • ...
  • 生物活性
    Description: Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. Hydrocortisone improves outcome by limiting this immunosuppressive feedback loop via an interleukin-10-dependent elimination of dendritic cell by natural killer cells. Chronic administration of hydrocortisone leads to deficits in certain tests of cognitive function sensitive to frontal lobe dysfunction and may contribute to the cognitive impairment reported in certain neuropsychiatric disorders. Hydrocortisone may reduce the extracellular spread of inflammation through the inhibition of matrix metalloproteinases.
    Targets: TNF-α | IL Receptor | AP-1 | MMP(e.g.TIMP) | NF-kB | IkB | IKK
    In vivo:
    Am J Respir Crit Care Med. 2003 Feb 15;167(4):512-20.
    Immunologic and hemodynamic effects of [Pubmed: 12426230]
    Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy.
    METHODS AND RESULTS:
    To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crossover study to receive either the first 100 mg of hydrocortisone as a loading dose and 10 mg per hour until Day 3 (n = 20) or placebo (n = 20), followed by the opposite medication until Day 6. Hydrocortisone infusion induced an increase of mean arterial pressure, systemic vascular resistance, and a decline of heart rate, cardiac index, and norepinephrine requirement. A reduction of plasma nitrite/nitrate indicated inhibition of nitric oxide formation and correlated with a reduction of vasopressor support. The inflammatory response (interleukin-6 and interleukin-8), endothelial (soluble E-selectin) and neutrophil activation (expression of CD11b, CD64), and antiinflammatory response (soluble tumor necrosis factor receptors I and II and interleukin-10) were attenuated. In peripheral blood monocytes, human leukocyte antigen-DR expression was only slightly depressed, whereas in vitro phagocytosis and the monocyte-activating cytokine interleukin-12 increased. Hydrocortisone withdrawal induced hemodynamic and immunologic rebound effects.
    CONCLUSIONS:
    In conclusion, hydrocortisone therapy restored hemodynamic stability and differentially modulated the immunologic response to stress in a way of antiinflammation rather than immunosuppression.
    J Clin Endocrinol Metab. 2001 Dec;86(12):5988-91.
    Hydrocortisone suppresses intranuclear activator-protein-1 (AP-1) binding activity in mononuclear cells and plasma matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9).[Pubmed: 11739475 ]
    Having demonstrated recently that hydrocortisone (HC) suppresses intranuclear and total cellular nuclear factor-kappa B (NF-kappa B) and increases inhibitor kappa B (I kappa B) in mononuclear cells (MNC), in vivo, we have now investigated the effect of hydrocortisone on the other major pro-inflammatory transcription factor, AP-1 and the two proteins, MMP-2 and MMP-9, whose transcription is modulated by it. MMP's hydrolyze extracellular matrix proteins and thus, allow the spread of inflammation.
    METHODS AND RESULTS:
    HC (100 mg) was given intravenously to eight normal subjects following an overnight fast. Blood samples were obtained at 0, 1, 2, 4, 8 and 24 h. MNC were separated and the nuclear fractions and cellular homogenates were prepared by standard techniques. AP-1 binding activity was measured by electrophoretic mobility shift assay (EMSA). Plasma MMP-2 and MMP-9 were measured by ELISA. AP-1 binding activity fell significantly at 1, 2, 4 and 8 h. Plasma MMP-2 concentration also decreased significantly at 1, 2, 4 and 8 h while MMP-9 decreased at 1 and 2 h.
    CONCLUSIONS:
    These data demonstrate that the acute anti-inflammatory effect of HC, in vivo, is, in part, due to AP-1 suppression and a reduction in MMP-2 and MMP-9. Thus, HC may reduce the extracellular spread of inflammation through the inhibition of matrix metalloproteinases.
    Psychopharmacology (Berl). 1999 Aug;145(3):260-6.
    The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers.[Pubmed: 10494574]
    Corticosteroids are elevated in certain neuropsychiatric disorders and this may contribute to the neuropsychological impairments reported in these disorders. To examine the effects of hydrocortisone on learning, memory and executive function.
    METHODS AND RESULTS:
    Hydrocortisone 20 mg was administered twice daily for 10 days to normal male volunteers in a randomized, placebo control, crossover, within-subject design. Learning, memory and executive function were measured using selected subtests from the Cambridge Neuropsychological Test Automated Battery. Hydrocortisone caused impairments of visuo-spatial memory. These included increased within search errors and impaired use of strategies on the spatial working memory subtest. In addition, administration of hydrocortisone was associated with more errors in the paired associate learning subtest, although no effect was found on the Tower of London. Hydrocortisone speeded response latencies in certain tests (pattern and spatial recognition memory).
    CONCLUSIONS:
    These results indicate that chronic administration of hydrocortisone leads to deficits in certain tests of cognitive function sensitive to frontal lobe dysfunction and may contribute to the cognitive impairment reported in certain neuropsychiatric disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7589 mL 13.7946 mL 27.5893 mL 55.1785 mL 68.9731 mL
    5 mM 0.5518 mL 2.7589 mL 5.5179 mL 11.0357 mL 13.7946 mL
    10 mM 0.2759 mL 1.3795 mL 2.7589 mL 5.5179 mL 6.8973 mL
    50 mM 0.0552 mL 0.2759 mL 0.5518 mL 1.1036 mL 1.3795 mL
    100 mM 0.0276 mL 0.1379 mL 0.2759 mL 0.5518 mL 0.6897 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    孕烯醇酮; Pregnenolone CFN99497 145-13-1 C21H32O2 = 316.5 20mg QQ客服:2056216494
    孕酮; 黄体素; 黄体酮; Progesterone CFN90039 57-83-0 C21H30O2 = 314.46 20mg QQ客服:3257982914
    6,7-二羟基欧奕二烯酮A; 6,7-Dihydroneridienone A CFN96120 72959-46-7 C21H28O3 = 328.5 5mg QQ客服:3257982914
    11β-羟基黄体酮; 11Beta-hydroxyprogesterone CFN90052 600-57-7 C21H30O3 = 330.46 20mg QQ客服:1413575084
    氢化可的松; Hydrocortisone CFN90033 50-23-7 C21H30O5 = 362.46 20mg QQ客服:215959384
    肾上腺酮; Corticosterone CFN90044 50-22-6 C21H30O4 = 346.46 20mg QQ客服:215959384
    欧奕二烯酮B; Neridienone B CFN97057 61671-56-5 C21H28O4 = 344.5 5mg QQ客服:1413575084
    21-去氧基欧奕二烯酮; 21-Deoxyneridienone B CFN97487 924910-83-8 C21H28O3 = 328.5 5mg QQ客服:3257982914

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