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  • 11β-羟基黄体酮

    • 11β-羟基黄体酮

    11Beta-hydroxyprogesterone

    11β-羟基黄体酮
    		产品编号 CFN90052
    CAS编号 600-57-7
    分子式 = 分子量 C21H30O3 = 330.46
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Steroids
    植物来源
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    11β-羟基黄体酮 CFN90052 600-57-7 10mg QQ客服：2056216494
    11β-羟基黄体酮 CFN90052 600-57-7 20mg QQ客服：2056216494
    11β-羟基黄体酮 CFN90052 600-57-7 50mg QQ客服：2056216494
    11β-羟基黄体酮 CFN90052 600-57-7 100mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals.2022, 15(4), 402.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Nutrients.2018, 11(1):E17
  • Journal of Functional Foods2022, 91:105019.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Int Immunopharmacol.2022, 106:108603.
  • Front Pharmacol.2020, 11:251.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • China Pharmacy2015, 26(27)
  • Green Chemistry2021, ISSUE 2.
  • Sci Rep.2023, 13(1):13072.
  • Research on Crops.2017, 18(3):569
  • Biorxiv.2020, doi: 10.1101.
  • Metabolites.2023, 13(5):625.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Toxicol In Vitro.2023, 86:105521.
  • Biomed Pharmacother.2024, 173:116319.
  • Molecules 2022, 27(3),960.
  • Mol Immunol. 2016, 78:121-132
  • Forensic Sci Int.2022, 341:111475.
  • J Ethnopharmacol.2024, 326:117902.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Nat Commun.2021, 12(1):681.
  • ...
    • 生物活性
    Description: The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
    Targets: Sodium Channel
    In vivo:
    Hypertension. 1996 Mar;27(3 Pt 1):421-5.
    11alpha- and 11beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat.[Pubmed: 8698448]
    The progesterone derivatives 11alpha-hydroxyprogesterone and 11Beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxysteroid dehydrogenase metabolizes active glucocorticoids to their inactive 11-dehydro products and protects renal mineralocorticoid receptors from the high circulating levels of endogenous glucocorticoids. 11 beta-Hydroxysteroid dehydrogenase has been suggested to be important not only in the control of renal sodium retention but also of blood pressure.
    METHODS AND RESULTS:
    To assess the possible blood pressure-modulating effects of 11alpha- and 11Beta-hydroxyprogesterone , we infused these substances into both intact and adrenalectomized Sprague-Dawley rats continuously for 14 days. Both 11alpha- and 11Beta-hydroxyprogesterone caused a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. The hypertensive effects of 11alpha-hydroxyprogesterone were abolished by adrenalectomy and significantly attenuated when 11alpha-hydroxyprogesterone was infused together with the specific mineralocorticoid receptor antagonist RU28318. In an additional series of experiments, 11alpha-hydroxyprogesterone significantly amplified the hypertensive effects of corticosterone in adrenalectomized spontaneously hypertensive rats but had no effects by itself in this experimental animal.
    CONCLUSIONS:
    These results demonstrate that both 11alpha-hydroxyprogesterone and 11Beta-hydroxyprogesterone are potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors. 11Beta-hydroxyprogesterone , and similar endogenous progesterone metabolites that inhibit 11 beta-hydroxysteroid dehydrogenase, may be involved in the pathology of certain hypertensive states.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0261 mL 15.1304 mL 30.2608 mL 60.5217 mL 75.6521 mL
    5 mM 0.6052 mL 3.0261 mL 6.0522 mL 12.1043 mL 15.1304 mL
    10 mM 0.3026 mL 1.513 mL 3.0261 mL 6.0522 mL 7.5652 mL
    50 mM 0.0605 mL 0.3026 mL 0.6052 mL 1.2104 mL 1.513 mL
    100 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.6052 mL 0.7565 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    孕烯醇酮; Pregnenolone CFN99497 145-13-1 C21H32O2 = 316.5 20mg QQ客服：1457312923
    孕酮； 黄体素； 黄体酮; Progesterone CFN90039 57-83-0 C21H30O2 = 314.46 20mg QQ客服：1413575084
    6,7-二羟基欧奕二烯酮A; 6,7-Dihydroneridienone A CFN96120 72959-46-7 C21H28O3 = 328.5 5mg QQ客服：215959384
    11β-羟基黄体酮; 11Beta-hydroxyprogesterone CFN90052 600-57-7 C21H30O3 = 330.46 20mg QQ客服：1457312923
    氢化可的松; Hydrocortisone CFN90033 50-23-7 C21H30O5 = 362.46 20mg QQ客服：2056216494
    肾上腺酮; Corticosterone CFN90044 50-22-6 C21H30O4 = 346.46 20mg QQ客服：215959384
    欧奕二烯酮B; Neridienone B CFN97057 61671-56-5 C21H28O4 = 344.5 5mg QQ客服：1413575084
    21-去氧基欧奕二烯酮; 21-Deoxyneridienone B CFN97487 924910-83-8 C21H28O3 = 328.5 5mg QQ客服：1413575084

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