Glycinol

	产品编号	CFN95122
	CAS编号	69393-95-9
	分子式 = 分子量	C₁₅H₁₂O₅ = 272.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Derris robusta
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产品名称	产品编号	CAS编号	包装	QQ客服
Glycinol	CFN95122	69393-95-9	1mg	QQ客服：2159513211
Glycinol	CFN95122	69393-95-9	5mg	QQ客服：2159513211
Glycinol	CFN95122	69393-95-9	10mg	QQ客服：2159513211
Glycinol	CFN95122	69393-95-9	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Northeast Normal University Changchun (China)

University of Brasilia (Brazil)

The Australian National University (Australia)

National Cancer Center Research Institute (Japan)

Imperial College London (United Kingdom)

Shanghai University of TCM (China)

University of Indonesia (Indonesia)

Nanjing University of Chinese Medicine (China)

Universidade da Beira Interior (Germany)

Universidad de Antioquia (Colombia)

Macau University of Science and Technology (China)

University of Maryland (USA)

Mendel University in Brno (Czech Republic)

More...

Description:

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.

In vitro:

Regen Med. 2017 Jul;12(5):513-524.

Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.[Pubmed: 28718749 ]

Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential.
METHODS AND RESULTS:
The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). BMSCs isolated from older donors demonstrated reduced osteogenesis. 17β-estradiol and glycinol exposure rescued the age-related reduction in osteogenic differentiation of BMSCs. These results correlated with the induction of osteogenic genes and estrogen receptor-α (ER-α) following glycinol treatment. ER antagonist studies further support that glycinol promotes osteogenesis through ER signaling.
CONCLUSIONS:
The results from these studies support investigating glycinol as a potential preventive or treatment for osteoporosis.

In vivo:

Eksp Klin Farmakol. 2010 Oct;73(10):21-4.

[Influence of new neurohypophyseal hormone analogs on sodium and water reabsorption in rat kidney].[Pubmed: 21254509]

New analogs of some neurohypophyseal hormones (oxypressin, hydrin, glumitocin, vasotocin) have been synthesized.
METHODS AND RESULTS:
Experiments with injection of these peptides to rats showed that substitution of C-terminal glycinamide on beta-ethanolamine (glycinol) or ethylamine in 1-deamino-arginine vasotocin resulted in loss of natriuretic but not antidiuretic activity.
CONCLUSIONS:
Analogs of oxypressin and hydrin exhibited neither natriuretic activity nor ability to affect water reabsorption. Glumitocin analog induced renal sodium ion excretion and did not influence potassium ion excretion.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3,9-二羟基紫檀碱; 3,9-Dihydroxypterocarpan	CFN97043	61135-91-9	C₁₅H₁₂O₄ = 256.3	5mg	QQ客服：3257982914
异美迪紫檀素; Isomedicarpin	CFN97226	74560-05-7	C₁₆H₁₄O₄ = 270.3	5mg	QQ客服：2056216494
美迪紫檀素; Medicarpin	CFN98411	32383-76-9	C₁₆H₁₄O₄ = 270.3	10mg	QQ客服：2056216494
美迪紫檀素-3-O-葡萄糖苷; Medicarpin 3-O-glucoside	CFN89498	52766-70-8	C₂₂H₂₄O₉ = 432.42	5mg	QQ客服：1413575084
Glycinol; Glycinol	CFN95122	69393-95-9	C₁₅H₁₂O₅ = 272.3	5mg	QQ客服：2159513211
6alpha-羟基美迪紫檀素; 6alpha-Hydroxymedicarpin	CFN96029	61135-92-0	C₁₆H₁₄O₅ = 286.3	5mg	QQ客服：2159513211
3,9-二甲氧基紫檀碱; 高紫檀素; Homopterocarpin	CFN97720	606-91-7	C₁₇H₁₆O₄ = 284.31	5mg	QQ客服：2159513211
(-)-Variabilin; (-)-Variabilin	CFN97945	370102-93-5	C₁₇H₁₆O₅ = 300.3	5mg	QQ客服：1457312923
3-羟基-9,10-二甲氧基紫檀烷; Methylnissolin	CFN90838	73340-41-7	C₁₇H₁₆O₅ = 300.3	10mg	QQ客服：2159513211
美迪紫檀苷; Methylnissolin-3-O-glucoside	CFN93199	94367-42-7	C₂₃H₂₆O₁₀ = 462.5	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6724 mL	18.3621 mL	36.7242 mL	73.4484 mL	91.8105 mL
5 mM	0.7345 mL	3.6724 mL	7.3448 mL	14.6897 mL	18.3621 mL
10 mM	0.3672 mL	1.8362 mL	3.6724 mL	7.3448 mL	9.1811 mL
50 mM	0.0734 mL	0.3672 mL	0.7345 mL	1.469 mL	1.8362 mL
100 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.7345 mL	0.9181 mL