波棱酮

Herpetone

	产品编号	CFN90676
	CAS编号	951677-22-8
	分子式 = 分子量	C₂₉H₃₀O₉ = 522.54
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The fruits of Herpetospermum pedunculosum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
波棱酮	CFN90676	951677-22-8	1mg	QQ客服：1457312923
波棱酮	CFN90676	951677-22-8	5mg	QQ客服：1457312923
波棱酮	CFN90676	951677-22-8	10mg	QQ客服：1457312923
波棱酮	CFN90676	951677-22-8	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Aveiro University (Portugal)

Chinese University of Hong Kong (China)

Istanbul University (Turkey)

University of Lodz (Poland)

Calcutta University (India)

Universit?t Basel (Switzerland)

Utrecht University (Netherlands)

Florida International University (USA)

Sant Gadge Baba Amravati University (India)

Deutsches Krebsforschungszentrum (Germany)

MTT Agrifood Research Finland (Finland)

Worcester Polytechnic Institute (USA)

University of Eastern Finland (Finland)

Chungnam National University (Korea)

More...

Description:

Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity.

Targets:

HBV

In vitro:

Molecules. 2016 Dec 27;22(1). pii: E14.

Anti-HBV Activities of Three Compounds Extracted and Purified from Herpetospermum Seeds.[Pubmed: 28035986 ]

The goal of this research was to evaluate the anti-hepatitis B virus (HBV) activities of three compounds extracted and purified from Herpetospermum seeds (HS) on HepG2.2.15 cells.
METHODS AND RESULTS:
Herpetin (HPT), Herpetone (HPO), and herpetfluorenone (HPF) were isolated from HS and identified using HR-ESI-MS and NMR. Different concentrations of the drugs were added to the HepG2.2.15 cells. Cell toxicity was observed with an MTT assay, cell culture supernatants were collected, and HBsAg and HBeAg were detected by ELISA. The content of HBV DNA was determined via quantitative polymerase chain reaction (PCR) with fluorescent probes. The 50% toxicity concentration (TC50) of HPF was 531.48 μg/mL, suggesting that this species is less toxic than HPT and HPO.
CONCLUSIONS:
HPT and HPF showed more potent antiviral activities than HPO. The 50% inhibition concentration (IC50) values of HPF on HBsAg and HBeAg were 176.99 and 134.53 μg/mL, respectively, and the corresponding therapeutic index (TI) values were 2.66 and 3.49, respectively. HPT and HPF were shown to significantly reduce the level of HBV DNA in the HepG2.2.15 culture medium compared to the negative control. This initial investigation of the anti-HBV constituents of HS yielded three compounds that revealed a synergistic effect of multiple components in the ethnopharmacological use of HS.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
松脂素二甲醚; Pinoresinol dimethyl ether	CFN90879	29106-36-3	C₂₂H₂₆O₆ = 386.4	20mg	QQ客服：1413575084
桉脂素; Eudesmin	CFN96266	526-06-7	C₂₂H₂₆O₆ = 386.4	20mg	QQ客服：2159513211
3,4,5'-Trimethoxy-3',4'-methylenedioxy-7,9':7',9-diepoxylignan; 3,4,5'-Trimethoxy-3',4'-methylenedioxy-7,9':7',9-diepoxylignan	CFN96935	873867-94-8	C₂₂H₂₄O₇ = 400.42	5mg	QQ客服：1413575084
二乙酸(+)-松脂醇酯; Pinoresinol diacetate	CFN98420	32971-25-8	C₂₄H₂₆O₈ = 442.5	5mg	QQ客服：1457312923
松脂醇-4-O-beta-D-吡喃葡萄糖苷; Pinoresinol 4-O-beta-D-glucopyranoside	CFN97180	69251-96-3	C₂₆H₃₂O₁₁ = 520.5	20mg	QQ客服：215959384
(+)-表松脂素-4′-O-β-D-葡萄糖苷; Epipinoresinol-4-O-beta-D-glucoside	CFN80044	24404-49-7	C₂₆H₃₂O₁₁ = 520.52	5mg	QQ客服：1413575084
松脂醇二葡萄糖苷; Pinoresinol diglucoside	CFN99994	63902-38-5	C₃₂H₄₂O₁₆ = 682.67	20mg	QQ客服：1457312923
8-羟基松脂醇-4'-O-beta-D-吡喃葡萄糖苷; 8-Hydroxypinoresinol-4'-O-beta-D-glucopyranoside	CFN95356	102582-69-4	C₂₆H₃₂O₁₂ = 536.5	5mg	QQ客服：1457312923
8-羟基松脂醇二葡萄糖苷; 8-Hydroxypinoresinol diglucoside	CFN95083	112747-99-6	C₃₂H₄₂O₁₇ = 698.7	5mg	QQ客服：2056216494
8-羟基松脂醇; 8-Hydroxypinoresinol	CFN92432	81426-17-7	C₂₀H₂₂O₇ = 374.4	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9137 mL	9.5686 mL	19.1373 mL	38.2746 mL	47.8432 mL
5 mM	0.3827 mL	1.9137 mL	3.8275 mL	7.6549 mL	9.5686 mL
10 mM	0.1914 mL	0.9569 mL	1.9137 mL	3.8275 mL	4.7843 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	0.7655 mL	0.9569 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.3827 mL	0.4784 mL