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  • 鹤氏唐松草碱

    Hernandezine

    鹤氏唐松草碱
    产品编号 CFN89519
    CAS编号 6681-13-6
    分子式 = 分子量 C39H44N2O7 = 652.77
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Thalictrum podocarpum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鹤氏唐松草碱 CFN89519 6681-13-6 1mg QQ客服:1413575084
    鹤氏唐松草碱 CFN89519 6681-13-6 5mg QQ客服:1413575084
    鹤氏唐松草碱 CFN89519 6681-13-6 10mg QQ客服:1413575084
    鹤氏唐松草碱 CFN89519 6681-13-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University of Science and Technology (Korea)
  • University of Toulouse (France)
  • Medizinische Universit?t Wien (Austria)
  • Macau University of Science and Technology (China)
  • Monash University (Australia)
  • Pennsylvania State University (USA)
  • Ateneo de Manila University (Philippines)
  • Universidad Industrial de Santander (Colombia)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of Hull (United Kingdom)
  • University of Vigo (Spain)
  • Utah State University (USA)
  • Shanghai University of TCM (China)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • J. Food Composition and Anal.2022, V 109:104482.
  • Molecules.2018, 23(10):E2638
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Crystals2020, 10(3), 206.
  • Phytother Res.2019, 33(5):1490-1500
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Pharmaceuticals.2022, 15(4), 402.
  • Mol Med Rep.2023 Oct;28(4):193.
  • Pest Manag Sci.2023, 79(8):2675-2685.
  • Front Plant Sci.2021, 12:673337.
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • J AOAC Int.2021, 104(6):1634-1651.
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Pathogens.2018, 7(3):E62
  • J Ethnopharmacol.2018, 210:88-94
  • J Ethnopharmacol.2022, 282:114574.
  • Pharmacol Rep.2019, 71(2):289-298
  • Oncotarget.2017, 8(64):108006-108019
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Environ Toxicol.2021, doi: 10.1002
  • Iranian Journal of Pharmaceutical Sciences2021, 17(2):25-36
  • PLoS One.2021, 16(6):e0248479.
  • ...
  • 生物活性
    Description: Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα expression/production in human macrophage cells (THP-1 and U937 lines). Hernandezine is a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells, it induces autophagic cell death in drug-resistant cancers. Hernandezine inhibits calcium-depletion stimulated calcium entry in human and bovine endothelial cells.
    Targets: AMPK | TNF-α | ROS | NF-kB | Autophagy | Calcium Channel
    In vitro:
    J Nat Prod. 2016 Aug 26;79(8):2135-42.
    Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.[Pubmed: 27504669 ]
    Considering the wide range of diversity and relatively nontoxic nature of natural products, developing a potential modulator of ABCB1 from natural sources is particularly valuable.
    METHODS AND RESULTS:
    Through screening of a large collection of purified bioactive natural products, Hernandezine was identified as a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells. Experimental data demonstrated that the bisbenzylisoquinoline alkaloid Hernandezine is selective for ABCB1, effectively inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. More importantly, Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations.
    CONCLUSIONS:
    Collectively, these findings reveal that Hernandezine has great potential to be further developed into a novel reversal agent for combination therapy in MDR cancer patients.
    Oncotarget. 2016 Feb 16;7(7):8090-104.
    Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers.[Pubmed: 26811496]
    Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours.
    METHODS AND RESULTS:
    Here, we showed that isoquinoline alkaloids, including liensinine, isoliensinine, dauricine, cepharanthine and Hernandezine, putatively induce cytotoxicity against a repertoire of cancer cell lines (HeLa, A549, MCF-7, PC3, HepG2, Hep3B and H1299). Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). Hernandezine possess the highest efficacy in provoking such cell death when compared with other examined compounds. We confirmed that isoquinoline alkaloid is structurally varied from the existing direct AMPK activators.
    CONCLUSIONS:
    In conclusion, isoquinoline alkaloid is a new class of compound that induce autophagic cell death in drug-resistant fibroblasts or cancers by exhibiting its direct activation on AMPK.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5319 mL 7.6597 mL 15.3193 mL 30.6387 mL 38.2983 mL
    5 mM 0.3064 mL 1.5319 mL 3.0639 mL 6.1277 mL 7.6597 mL
    10 mM 0.1532 mL 0.766 mL 1.5319 mL 3.0639 mL 3.8298 mL
    50 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.6128 mL 0.766 mL
    100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3064 mL 0.383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    汉防己甲素; 粉防己碱; Tetrandrine CFN99166 518-34-3 C38H42N2O6 = 622.76 20mg QQ客服:215959384
    芬氏唐松草碱; Thalidezine CFN89488 18251-36-0 C38H42N2O7 = 638.74 5mg QQ客服:2056216494
    鹤氏唐松草碱; Hernandezine CFN89519 6681-13-6 C39H44N2O7 = 652.77 5mg QQ客服:1457312923
    防己诺林碱; 粉防己乙素; 汉防己乙素; 去甲粉防己碱; Fangchinoline CFN99167 436-77-1 C37H40N2O6 = 608.71 20mg QQ客服:1413575084
    (-)-箭毒素; (-)-Curine CFN90532 436-05-5 C36H38N2O6 = 594.69 5mg QQ客服:2056216494
    汉防己乙素; Demethyl tetrandrine CFN90482 33889-68-8 C37H40N2O6 = 608.72 20mg QQ客服:1413575084
    Thalrugosidine; Thalrugosidine CFN89510 33954-34-6 C38H42N2O7 = 638.74 5mg QQ客服:215959384
    异粉防己碱N-2'-氧化物; Isotetrandrine N-2'-oxide CFN97190 70191-83-2 C38H42N2O7 = 638.8 5mg QQ客服:2056216494
    头花千金藤醇灵碱; Cepharanoline CFN91640 27686-34-6 C36H36N2O6 = 592.68 5mg QQ客服:2056216494
    千金藤素; Cepharanthine CFN98570 481-49-2 C37H38N2O6 = 606.71 20mg QQ客服:3257982914

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