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  • Heliangin

    • Heliangin

    Heliangin

    Heliangin
    		产品编号 CFN96222
    CAS编号 13323-48-3
    分子式 = 分子量 C20H26O6 = 362.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Helianthus tuberosus L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Heliangin CFN96222 13323-48-3 1mg QQ客服：2056216494
    Heliangin CFN96222 13323-48-3 5mg QQ客服：2056216494
    Heliangin CFN96222 13323-48-3 10mg QQ客服：2056216494
    Heliangin CFN96222 13323-48-3 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Kyung Hee University (Korea)
  • Sri Ramachandra University (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Worcester Polytechnic Institute (USA)
  • Pennsylvania State University (USA)
  • Universit?t Basel (Switzerland)
  • Medical University of Gdansk (Poland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • The Ohio State University (USA)
  • Chungnam National University (Korea)
  • University of Hertfordshire (United Kingdom)
  • University of Dicle (Turkey)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Biomolecules2021, 11(10),1513.
  • Horticulturae2021, 7(1),5.
  • Molecules2022, 27(14):4601
  • The Journal of Korean Medicine2023, 44(4):26-40.
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • J. Food Composition and Anal.2022, V 109:104482.
  • bioRxiv - Biochemistry2023, 541790.
  • Food Chemistry2023, 137837.
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Evid Based Complement Alternat Med.2021, 8855980.
  • J Ethnopharmacol.2022, 282:114574.
  • Biomed Pharmacother.2022, 145:112474.
  • Int J Mol Sci.2020, 21(22):8816.
  • Biol Pharm Bull.2017, 40(6):797-806
  • Food Research2022, 6(6): 30-38.
  • Antioxidants (Basel).2021, 10(1):112.
  • Food Res Int.2020, 133:109130.
  • Free Radic Biol Med.2021, 166:104-115.
  • Saf Health Work.2019, 10(2):196-204
  • J. of The Korean Society of Food Culture2017, 144-149
  • Plants (Basel).2023, 12(5):1120.
  • ...
    • 生物活性
    Description: Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells.
    Targets: MAPK | NF-kB | TNF-α | IL Receptor | PGE
    In vivo:
    Biomed Pharmacother. 2017 Apr;88:102-8.
    Heliangin inhibited lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells.[Pubmed: 28095354 ]
    The Heliangin is a natural agent mainly isolated from Helianthus tuberosus L. (Asteraceae). In order to investigate the anti-inflammatory effect of Heliangin, several typical models in vivo and in vitro were performed.
    METHODS AND RESULTS:
    The RAW264.7 mouse macrophages cells were employed in vitro and dexamethasone were conducted as positive. The cytotoxicity results of Heliangin on RAW 264.7 cells provided the safety in vitro for further study.Moreover, we founded that MAPK and NF-κB signaling pathway play important roles in Heliangin's activity on RAW264.7 cells. Secondly, the acute toxic study results of Heliangin manifested the safety in vivo. Heliangin exerted anti-inflammation effect in a xylene-induced ear swelling in BALB/C mice and carrageenan-induced paw edema model in SD rats. The cytokines levels (TNF-α, IL-6 and PGE2) were decreased.
    CONCLUSIONS:
    The paw tissue immunochemistry assay demonstrated the IL-6 protein level changes in carrageenan-induced paw edema model under Heliangin administration.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7594 mL 13.7969 mL 27.5938 mL 55.1876 mL 68.9845 mL
    5 mM 0.5519 mL 2.7594 mL 5.5188 mL 11.0375 mL 13.7969 mL
    10 mM 0.2759 mL 1.3797 mL 2.7594 mL 5.5188 mL 6.8985 mL
    50 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.1038 mL 1.3797 mL
    100 mM 0.0276 mL 0.138 mL 0.2759 mL 0.5519 mL 0.6898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    地胆草种内酯; Scabertopin CFN97798 185213-52-9 C20H22O6 = 358.39 20mg QQ客服：2056216494
    异地胆草种内酯; Isoscabertopin CFN97740 439923-16-7 C20H22O6 = 358.39 20mg QQ客服：3257982914
    地胆草内酯B; Elephscabertopin B CFN95734 2522820-34-2 C19H20O7 = 360.4 5mg QQ客服：3257982914
    Elephantopinolide D; Elephantopinolide D CFN95735 2522817-71-4 C20H22O7 = 374.4 5mg QQ客服：3257982914
    8beta-(4'-Hydroxytigloyloxy)costunolide; 8beta-(4'-Hydroxytigloyloxy)costunolide CFN92903 94190-32-6 C20H26O5 = 346.42 5mg QQ客服：1457312923
    Neobritannilactone B; Neobritannilactone B CFN92602 886990-00-7 C15H20O3 = 248.3 5mg QQ客服：215959384
    2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide CFN90346 72229-33-5 C15H20O4 = 264.32 5mg QQ客服：3257982914
    表美国鹅掌楸内酯; Epitulipinolide CFN98252 24164-13-4 C17H22O4 = 290.4 5mg QQ客服：3257982914
    小白菊内酯; Parthenolide CFN98034 20554-84-1 C15H20O3 = 248.3 20mg QQ客服：2159513211
    鹅掌揪内酯; Lipiferolide CFN98642 41059-80-7 C17H22O5 = 306.4 5mg QQ客服：3257982914

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