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  • Neobritannilactone B

    Neobritannilactone B

    Neobritannilactone B
    产品编号 CFN92602
    CAS编号 886990-00-7
    分子式 = 分子量 C15H20O3 = 248.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Inula japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Neobritannilactone B CFN92602 886990-00-7 1mg QQ客服:2159513211
    Neobritannilactone B CFN92602 886990-00-7 5mg QQ客服:2159513211
    Neobritannilactone B CFN92602 886990-00-7 10mg QQ客服:2159513211
    Neobritannilactone B CFN92602 886990-00-7 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Harvard University (USA)
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  • Medizinische Universit?t Wien (Austria)
  • Periyar University (India)
  • Universidad Miguel Hernández (Spain)
  • Istanbul University (Turkey)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Plant Archives2020, 2(1),2929-2934
  • Biomedicines.2021, 9(8):954.
  • Reprod Toxicol.2020, 96:1-10.
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Front. Plant Sci.2022, 13:757852.
  • Food Res Int.2020, 128:108778
  • Int J Mol Med.2019, 43(6):2516-2522
  • Molecules.2019, 24(23):E4303
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Journal of Functional Foods2021, 84:104581
  • Spectrochim Acta A2019, 210:372-380
  • Nutrients.2021, 13(8):2901.
  • Plants (Basel).2021, 10(7):1376.
  • PLoS One.2018, 13(11):e0208055
  • Antioxidants (Basel).2021, 10(3):379.
  • Phytother Res.2015, 29(7):1088-96
  • Molecules.2019, 24(19):E3417
  • Molecules.2019, 24(21):E3834
  • PLoS One.2015, 10(5):e0127060
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Nat Chem Biol.2018, 14(8):760-763
  • ...
  • 生物活性
    Description: Neobritannilactone B has cytotoxic activity.
    In vitro:
    Arch Pharm Res. 2014 May;37(5):567-74.
    Hypo-pigmenting effect of sesquiterpenes from Inula britannica in B16 melanoma cells.[Pubmed: 24346861]
    During the course of screens to identify anti-melanogenic agents from natural resources, we found that the methanol extract of the dried flower of Inula britannica L. inhibited melanin synthesis in cultured melanoma cells stimulated with 3-isobutyl-1-methylxanthine (IBMX).
    METHODS AND RESULTS:
    A bioassay-guided isolation of the chloroform fraction of the I. britannica using an in vitro melanogenesis inhibition assay led to the isolation of sesquiterpenes, 1-O-acetylbritannilactone (1), britannilactone (2) and neobritannilactone B (3). Compounds 1 and 2 significantly reduced melanin production in a dose-dependent manner with IC50 values of 13.3 and 15.5 μM, respectively, whereas compound 3 was found to be cytotoxic. Compound 1 also inhibited the tyrosinase activity only in cell based-systems. Western blot analysis indicated that compound 1 inhibited melanogenesis by activating extracellular signal-regulated kinase (ERK) and Akt signaling and also inhibiting cAMP related binding protein, which regulates its downstream pathway, including tyrosinase, tyrosinase related protein-1 and TRP-2.
    CONCLUSIONS:
    These results demonstrated that compound 1, a major sesquiterpene from the flowers of I. britannica, exhibited anti-melanogenic activity by suppression of tyrosinase expression via ERK and Akt signaling. Taken together, our results suggest that these compounds may act as potent natural skin-lightening agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
    5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
    10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
    50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide CFN98630 39815-40-2 C17H22O6 = 322.4 5mg QQ客服:3257982914
    Heliangin; Heliangin CFN96222 13323-48-3 C20H26O6 = 362.4 5mg QQ客服:2159513211
    8beta-(4-Hydroxytigloyloxy)ovatifolin; 8beta-(4-Hydroxytigloyloxy)ovatifolin CFN96820 554449-27-3 C22H28O7 = 404.45 5mg QQ客服:2056216494
    Demethylsonchifolin; Demethylsonchifolin CFN97591 956384-55-7 C20H24O6 = 360.41 5mg QQ客服:215959384
    Uvedalin; Uvedalin CFN97776 24694-79-9 C23H28O9 = 448.47 5mg QQ客服:1413575084
    沼菊素氯海德林; Enhydrin chlorohydrin CFN97746 38230-99-8 C23H29ClO10 = 500.93 5mg QQ客服:1413575084
    Chlorouvedalin; Chlorouvedalin CFN97775 24694-80-2 C23H29ClO9 = 484.93 5mg QQ客服:1457312923
    异去氧苦地胆苦素; Isodeoxyelephantopin CFN97745 38927-54-7 C19H20O6 = 344.36 5mg QQ客服:215959384
    去氧苦地胆苦素; Deoxyelephantopin CFN97764 29307-03-7 C19H20O6 = 344.36 5mg QQ客服:3257982914
    地胆草种内酯; Scabertopin CFN97798 185213-52-9 C20H22O6 = 358.39 5mg QQ客服:2056216494

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