匙羹藤新苷元

Gymnemagenin

	产品编号	CFN90961
	CAS编号	22467-07-8
	分子式 = 分子量	C₃₀H₅₀O₆ = 506.71
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The leaves of Gymnema sylvestre.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
匙羹藤新苷元	CFN90961	22467-07-8	1mg	QQ客服：1413575084
匙羹藤新苷元	CFN90961	22467-07-8	5mg	QQ客服：1413575084
匙羹藤新苷元	CFN90961	22467-07-8	10mg	QQ客服：1413575084
匙羹藤新苷元	CFN90961	22467-07-8	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wisconsin-Madison (USA)

University of Stirling (United Kingdom)

Universidade Católica Portuguesa (Portugal)

University of Parma (Italy)

Universidade Federal de Goias (UFG) (Brazil)

Chinese University of Hong Kong (China)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

University of Perugia (Italy)

Korea Intitute of Science and Technology (KIST) (Korea)

Universidad de La Salle (Mexico)

John Innes Centre (United Kingdom)

Biotech R&D Institute (USA)

Lund University (Sweden)

University of Fribourg (Switzerland)

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Description:

Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity, it can be considered further for development into a potent anti-diabetic drug.

Targets:

Liver X Receptor

In vitro:

J Theor Biol. 2016 Feb 21;391:95-101.

In-silico analysis of gymnemagenin from Gymnema sylvestre (Retz.) R.Br. with targets related to diabetes.[Pubmed: 26711684 ]

Diabetes is a metabolic disorder characterized by higher than normal glucose in the blood. Most oral hypoglycemic drugs available in market produce adverse side effects which have resulted in continued search for new therapeutic agents with little or no side effects. Herbal drugs are considered relatively safer alternatives and Gymnema sylvestre is one of the most well established natural remedy for diabetes and is traded worldwide under several brands.
METHODS AND RESULTS:
In the present study an attempt has been made to use in silico techniques to understand and predict the drug likeliness of gymnemagenin, one of the key constituents of G. sylvestre against 15 proteins having key role in carbohydrate metabolism. Gymnemagenin was found to dock well with crystallographic structures of 7 of the 15 selected targets and was found even better than the two known clinically used antidiabetic compounds, repaglinide and sitagliptin taken in the study for comparison.
CONCLUSIONS:
Gymnemagenin therefore can be considered further for development into a potent anti-diabetic drug.

In vivo:

J Agric Food Chem. 2012 Mar 14;60(10):2517-24.

Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.[Pubmed: 22360666 ]

Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats.
METHODS AND RESULTS:
The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
乙酰基-alpha-乳香酸; 3-O-Acetyl-alpha-boswellic acid	CFN90529	89913-60-0	C₃₂H₅₀O₄ = 498.74	10mg	QQ客服：1457312923
3beta-羟基齐墩果-12-烯-27-酸; Beta-Peltoboykinolic acid	CFN96343	24778-48-1	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：1413575084
3-软脂酸赤二醇酯; Erythrodiol 3-palmitate	CFN98004	19833-13-7	C₄₆H₈₀O₃ = 681.1	5mg	QQ客服：2159513211
23-羟基龙吉苷元; 23-Hydroxylongispinogenin	CFN90948	42483-24-9	C₃₀H₅₀O₄ = 474.72	5mg	QQ客服：215959384
匙羹藤苷元; Gymnestrogenin	CFN90966	19942-02-0	C₃₀H₅₀O₅ = 490.72	5mg	QQ客服：2159513211
匙羹藤新苷元; Gymnemagenin	CFN90961	22467-07-8	C₃₀H₅₀O₆ = 506.71	10mg	QQ客服：2159513211
21-O-巴豆酰基匙羹藤新苷元; 21-O-Tigloylgymnemagenin	CFN90978	1581276-63-2	C₃₅H₅₆O₇ = 588.81	5mg	QQ客服：2159513211
原七叶皂苷元; Protoescigenin	CFN70307	20853-07-0	C₃₀H₅₀O₆ = 506.7	5mg	QQ客服：2159513211
齐墩果-12-烯-3,24-二醇; Olean-12-ene-3,24-diol	CFN99305	119318-15-9	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：1457312923
大豆甾醇B; Soyasapogenol B	CFN97007	595-15-3	C₃₀H₅₀O₃ = 458.7	10mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9735 mL	9.8676 mL	19.7352 mL	39.4703 mL	49.3379 mL
5 mM	0.3947 mL	1.9735 mL	3.947 mL	7.8941 mL	9.8676 mL
10 mM	0.1974 mL	0.9868 mL	1.9735 mL	3.947 mL	4.9338 mL
50 mM	0.0395 mL	0.1974 mL	0.3947 mL	0.7894 mL	0.9868 mL
100 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.3947 mL	0.4934 mL