| In vitro: |
| Chinese Journal of Medicinal Chemistry,2009,19(3):195-9. | | Triterpenoidal constituents of Pericampylus glaucus and their antitumor activity in vitro[Reference: WebLink] | To investigate triterpenoidal constituents of Pericampylus glaucus(Lam.)Merr.and to eva-luate their antitumor activities.
METHODS AND RESULTS:
Various chromatographic means were used for the isolation of triterpenes and the compounds obtained were identified by the spectroscopic method.Antitumor activities were also assayed by MTT method. Five triterpenes were isolated from Pericampylus glaucus and identified as hopenone-B(1),hopenol-B(2),22-hydroxyhopan-3-one(3),Erythrodiol 3-palmitate(4),and 5β,24-cyclofriedelan-3-one(5),respectively.Among them,compound 4 inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 μg·mL-1,while others did not show inhibitory effect at the concentration tested.
CONCLUSIONS:
Compounds 1-5 were isolated from the genus Pericampylus for the first time.Compound 4 is the first reported antitumor constituent of Pericampylus glaucus and its antitumor activity was also assayed for the first time.The 13C-NMR data for 2 and the 1H-NMR and 13C-NMR data for 1 and 5 were reported for the first time. |
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