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  • 蓝萼甲素

    Glaucocalyxin A

    蓝萼甲素
    产品编号 CFN90207
    CAS编号 79498-31-0
    分子式 = 分子量 C20H28O4 = 332.43
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Rabdosia rubescens.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蓝萼甲素 CFN90207 79498-31-0 1mg QQ客服:215959384
    蓝萼甲素 CFN90207 79498-31-0 5mg QQ客服:215959384
    蓝萼甲素 CFN90207 79498-31-0 10mg QQ客服:215959384
    蓝萼甲素 CFN90207 79498-31-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Antioquia (Colombia)
  • University of Eastern Finland (Finland)
  • University of Oslo (Norway)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Illinois at Chicago (USA)
  • Medizinische Universit?t Wien (Austria)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of East Anglia (United Kingdom)
  • Semmelweis Unicersity (Hungary)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Shanghai Institute of Organic Chemistry (China)
  • Siksha O Anusandhan University (India)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Wollongong (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2022, 157:111397.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Int J Mol Sci.2021, 22(11):5503.
  • Molecules.2019, 24(21):E3834
  • Int Immunopharmacol.2020, 90:107268.
  • Oncotarget.2016, 8(51):88386-88400
  • Foods.2020, 9(10):1348.
  • J Appl Toxicol.2020, 40(7):965-978.
  • Analytical Letters 2021, 54(4).
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Univerzita Karlova2021, 20.500.11956.
  • J Ethnopharmacol.2020, 260:112988.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.
  • Molecules2021, 26(1),230
  • Int Immunopharmacol.2019, 71:22-31
  • Food Chem.2022, 373(Pt B):131364.
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Front Plant Sci.2021, 12:673337.
  • Molecules.2021, 26(2):E255.
  • Neuropharmacology2019, 151437
  • Molecules.2019, 24(6):E1155
  • ...
  • 生物活性
    Description: Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand. Glaucocalyxin A has regulation of microglia activity, can attenuate lipopolysaccharide -stimulated neuroinflammation through NF-κB and p38 MAPK signaling pathways.Glaucocalyxin A may become a potential anti-fibrotic agent in Idiopathic pulmonary fibrosis (IPF) management, it can effectively ameliorate pulmonary fibrosis through the antagonism of leukocyte infiltration and proinflammatory cytokine production.
    Targets: Akt | Caspase | Syk | JNK | p38MAPK | COX | IL Receptor | NF-kB | IkB | TNF-α | NO | IKK
    In vitro:
    Acta Biochim Biophys Sin (Shanghai). 2013 Nov;45(11):946-52.
    Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells.[Pubmed: 24041957]
    Akt is becoming an attractive target in the development of anti-tumor agents. In the present study, we aimed to discover novel negative Akt regulators against malignant glioma.
    METHODS AND RESULTS:
    An Akt regulator screening platform performed in an Akt-GFP overexpression cell line was developed, and natural product library was screened and evaluated using this platform. In addition, the cytotoxic effect of the regulator was detected by MTT assay. Cell apoptosis was assayed by Hoechst 33342 staining and flow cytometry analysis. Afterwards, the apoptotic signaling pathway was investigated by western blot analysis. Glaucocalyxin A, isolated from Rabdosia japonica, was identified as a potent negative regulator of Akt. In human-derived malignant glioma U87MG cells, glaucocalyxin A inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Furthermore, glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein.
    CONCLUSIONS:
    Taken together, these results indicated that glaucocalyxin A may become a promising candidate in the treatment of malignant glioma.
    Eur J Med Chem. 2014 Oct 30;86:235-41.
    Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents.[Pubmed: 25164762]
    A series of Mannich base type derivatives of Glaucocalyxin A (GLA) were designed and prepared.
    METHODS AND RESULTS:
    The cytotoxicity of these compounds was evaluated against six tumor cell lines (SMMC-7721, B16, SGC-7901, A549, KB, HL-60). Most compounds exhibited potent antiproliferative effects with low micromolar IC50 values. Compound 1 with para methyl benzyl amine moiety and compound 16 with cyclohexylamine moiety displayed the highest inhibition efficacy. Significantly, the cytotoxicity of compound 1 was much lower than GLA against the normal human liver cell (HL-7702). The in vitro stability assay revealed that transformation of GLA to Mannich base type derivatives improved the compound stability in rat plasma. Finally, decomposition product analysis supported that compound 1 could act as a prodrug and release GLA in the intracellular environment.
    PLoS One. 2013 Dec 30;8(12):e85120.
    Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.[Pubmed: 24386454]
    A series of Mannich base type derivatives of Glaucocalyxin A (GLA) were designed and prepared.
    METHODS AND RESULTS:
    The cytotoxicity of these compounds was evaluated against six tumor cell lines (SMMC-7721, B16, SGC-7901, A549, KB, HL-60). Most compounds exhibited potent antiproliferative effects with low micromolar IC50 values. Compound 1 with para methyl benzyl amine moiety and compound 16 with cyclohexylamine moiety displayed the highest inhibition efficacy. Significantly, the cytotoxicity of compound 1 was much lower than GLA against the normal human liver cell (HL-7702).
    CONCLUSIONS:
    The in vitro stability assay revealed that transformation of GLA to Mannich base type derivatives improved the compound stability in rat plasma. Finally, decomposition product analysis supported that compound 1 could act as a prodrug and release GLA in the intracellular environment.
    Thromb Haemost. 1992 Apr 2;67(4):458-60.
    Inhibition by glaucocalyxin A of aggregation of rabbit platelets induced by ADP, arachidonic acid and platelet-activating factor, and inhibition of [3H]-PAF binding.[Pubmed: 1631795]
    Glaucocalyxin A is a new diterpenoid isolated from the ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in the northeastern China.
    METHODS AND RESULTS:
    When it was incubated with washed rabbit platelets, glaucocalyxin A inhibited ADP- or arachidonic acid-induced platelet aggregation with IC50 values of 4.4 mumol/l, 14.1 mumol/l respectively. Glaucocalyxin A also inhibited PAF-induced aggregation of rabbit platelets which were refractory to ADP and arachidonic acid with an IC50 value of 13.7 mumol/l.
    CONCLUSIONS:
    Analysis of [3H]-PAF binding showed that glaucocalyxin A prevented [3H]-PAF binding to intact washed rabbit platelets with an IC50 value of 8.16 mumol/l, which was consistent with its inhibition of PAF-induced platelet aggregation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0082 mL 15.0408 mL 30.0815 mL 60.163 mL 75.2038 mL
    5 mM 0.6016 mL 3.0082 mL 6.0163 mL 12.0326 mL 15.0408 mL
    10 mM 0.3008 mL 1.5041 mL 3.0082 mL 6.0163 mL 7.5204 mL
    50 mM 0.0602 mL 0.3008 mL 0.6016 mL 1.2033 mL 1.5041 mL
    100 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    香茶菜乙素; Excisanin B CFN97269 78536-36-4 C22H32O6 = 392.5 5mg QQ客服:3257982914
    腺华素; Adenanthin CFN99215 111917-59-0 C26H34O9 = 490.6 5mg QQ客服:215959384
    苍山香茶菜素; Bulleyanin CFN99347 123043-54-9 C28H38O10 = 534.6 5mg QQ客服:2159513211
    蓝萼甲素; Glaucocalyxin A CFN90207 79498-31-0 C20H28O4 = 332.43 5mg QQ客服:215959384
    Excisanin A; Excisanin A CFN89365 78536-37-5 C20H30O5 = 350.44 5mg QQ客服:215959384
    凉山香茶菜素A; Liangshanin A CFN99342 122717-54-8 C20H26O4 = 330.4 5mg QQ客服:2056216494
    叶含乙酰瘿花香茶菜素A; Rosthornin A CFN99364 125164-55-8 C22H32O5 = 376.5 5mg QQ客服:2056216494
    叶含乙酰瘿花香茶菜素B; Rosthornin B CFN99365 125181-21-7 C24H34O7 = 434.5 5mg QQ客服:2159513211
    滇杠柳素A; Forrestin A CFN99635 152175-76-3 C30H42O11 = 578.7 5mg QQ客服:215959384
    毛萼晶A; Maoecrystal A CFN98585 96850-30-5 C22H28O6 = 388.45 10mg QQ客服:2056216494

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