Info: Read More
  • 中药标准品生产商,产品定制服务
  • Excisanin A

    Excisanin A

    Excisanin A
    产品编号 CFN89365
    CAS编号 78536-37-5
    分子式 = 分子量 C20H30O5 = 350.44
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The aerial parts of Isodon inflexus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Excisanin A CFN89365 78536-37-5 1mg QQ客服:1413575084
    Excisanin A CFN89365 78536-37-5 5mg QQ客服:1413575084
    Excisanin A CFN89365 78536-37-5 10mg QQ客服:1413575084
    Excisanin A CFN89365 78536-37-5 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Malaya (Malaysia)
  • Florida International University (USA)
  • University of Hull (United Kingdom)
  • Srinakharinwirot University (Thailand)
  • University of Vienna (Austria)
  • Washington State University (USA)
  • The Australian National University (Australia)
  • University of Otago (New Zealand)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • National Cancer Center Research Institute (Japan)
  • Universidad de Buenos Aires (Argentina)
  • Kyung Hee University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:770667.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • J Agric Food Chem.2020, 68(51):15164-15175
  • J Pharm Anal.2016, 6(6):363-373
  • Journal of Ginseng Research2021, 15 June.
  • Reprod Toxicol.2020, 96:1-10.
  • FEBS Lett.2021, 595(20):2608-2615.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Pharmaceutics.2020, 12(9):845.
  • Comput Biol Chem.2019, 83:107096
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Genes Genomics.2020, 10.1007
  • Front Pharmacol.2021, 12:652860.
  • iScience.2020, 23(2):100849.
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Tea Res. Ins. Of China2017, 1-12
  • Molecules.2018, 23(7):E1817
  • JEJU National University2022, 10478.
  • China Pharmacy2015, 26(27)
  • J Ethnopharmacol.2017, 197:157-164
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Journal of Ginseng Research2021, 3 June.
  • ...
  • 生物活性
    Description: ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP).
    Targets: MMP(e.g.TIMP) | FAK | PI3K | Akt | GSK-3 | Wnt/β-catenin | NO | PARP | JNK | Caspase | NF-kB | PGE
    In vitro:
    Mol Cancer Ther. 2009 Apr;8(4):873-82.
    ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway.[Pubmed: 19372560 ]
    Isodon diterpenoids have received considerable phytochemical and biological attention for their strong antitumor activity with low toxicity.
    METHODS AND RESULTS:
    In this study, Excisanin A, a diterpenoid compound purified from Isodon Macrocalyxin D, was tested on human Hep3B and MDA-MB-453 cell lines and Hep3B xenograft models. The results showed Excisanin A could inhibit the proliferation of Hep3B and MDA-MB-453 cells via induction of apoptosis, with the evidence of increasing AnnexinV-positive cells and characteristic morphologic changes of apoptosis in the nucleus. Also, Excisanin A sensitized Hep3B cells to 5-fluorouracil treatment or MDA-MB-453 cells to ADM treatment in vitro. In Hep3B xenograft models, Excisanin A at 20 mg/kg/d remarkably decreased the xenograft tumor size and induced tumor cells apoptosis using transferase-mediated FITC-12-dUTP nick-end labeling assay. More importantly, we found that Excisanin A could inhibit AKT activity and block its signal pathway in vitro and in vivo. And treatment with Excisanin A significantly reduced the number of viable cells in Hep3B/myr-AKT1 cells more than that in control cells.
    CONCLUSIONS:
    Together, Excisanin A might be a potent inhibitor of AKT signaling pathway in tumor cells. These data provide validation for the development of Excisanin A to treat cancers displaying elevated levels of AKT.
    Planta Med. 2001 Jul;67(5):406-10.
    Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells.[Pubmed: 11488452]

    METHODS AND RESULTS:
    A methanolic extract of the whole plant of Isodon japonicus (Labiatae) showed potent inhibition on the LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW264.7 cells. Four known kaurane diterpenes were isolated by activity-guided fractionation and their structures were identified as kamebanin (1), kamebacetal A (2), kamebakaurin (3), Excisanin A (4). All compounds also inhibited the LPS-induced NF-kappaB activation as assessed by NF-kappaB reporter assay and electrophoretic mobility shift assay (EMSA). Compounds 2-4 showed comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.
    CONCLUSIONS:
    These results suggest that kaurane diterpenes could exert their inhibitory effects on the production of NO and PGE2 through the suppression of NF-kappaB activation, and be partially responsible for the anti-inflammatory activities of the genus Isodon.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8536 mL 14.2678 mL 28.5356 mL 57.0711 mL 71.3389 mL
    5 mM 0.5707 mL 2.8536 mL 5.7071 mL 11.4142 mL 14.2678 mL
    10 mM 0.2854 mL 1.4268 mL 2.8536 mL 5.7071 mL 7.1339 mL
    50 mM 0.0571 mL 0.2854 mL 0.5707 mL 1.1414 mL 1.4268 mL
    100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.5707 mL 0.7134 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    毛萼晶A; Maoecrystal A CFN98585 96850-30-5 C22H28O6 = 388.45 10mg QQ客服:215959384
    尾叶香茶菜戊素; Kamebanin CFN98628 39388-57-3 C20H30O4 = 334.5 5mg QQ客服:2159513211
    香茶菜乙素; Excisanin B CFN97269 78536-36-4 C22H32O6 = 392.5 5mg QQ客服:1413575084
    腺华素; Adenanthin CFN99215 111917-59-0 C26H34O9 = 490.6 5mg QQ客服:215959384
    苍山香茶菜素; Bulleyanin CFN99347 123043-54-9 C28H38O10 = 534.6 5mg QQ客服:215959384
    蓝萼甲素; Glaucocalyxin A CFN90207 79498-31-0 C20H28O4 = 332.43 5mg QQ客服:215959384
    Excisanin A; Excisanin A CFN89365 78536-37-5 C20H30O5 = 350.44 5mg QQ客服:1413575084
    凉山香茶菜素A; Liangshanin A CFN99342 122717-54-8 C20H26O4 = 330.4 5mg QQ客服:2159513211
    叶含乙酰瘿花香茶菜素A; Rosthornin A CFN99364 125164-55-8 C22H32O5 = 376.5 5mg QQ客服:1413575084
    叶含乙酰瘿花香茶菜素B; Rosthornin B CFN99365 125181-21-7 C24H34O7 = 434.5 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产