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  • 人参皂苷Rk3

    Ginsenoside Rk3

    产品编号 CFN92593
    CAS编号 364779-15-7
    分子式 = 分子量 C36H60O8 = 620.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rk3 CFN92593 364779-15-7 1mg QQ客服:2159513211
    人参皂苷Rk3 CFN92593 364779-15-7 5mg QQ客服:2159513211
    人参皂苷Rk3 CFN92593 364779-15-7 10mg QQ客服:2159513211
    人参皂苷Rk3 CFN92593 364779-15-7 20mg QQ客服:2159513211
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Imperial College London (United Kingdom)
  • Massachusetts General Hospital (USA)
  • Chungnam National University (Korea)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Melbourne University (Australia)
  • University of Padjajaran (Indonesia)
  • Cornell University (USA)
  • University of Maryland (USA)
  • Monash University Malaysia (Malaysia)
  • Pennsylvania State University (USA)
  • Biotech R&D Institute (USA)
  • Harvard University (USA)
  • Shanghai Institute of Organic Chemistry (China)
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  • J Microbiol Biotechnol.2020, 30(2):178-186.
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  • Molecules 2021, 26(4),1092.
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  • Molecules2022, 27(11):3606.
  • Metabolites.2020, 11(1):E11.
  • Tissue Cell.2022, 78:101901.
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • J Anal Toxicol.2021, bkab015.
  • J Biomol Struct Dyn.2022, 1-21.
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  • Phytochemistry.2017, 141:162-170
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  • ...
  • 生物活性
    Description: Ginsenoside Rk3 is often used as a major ingredient of the compound preparation for ischemic heart diseases, it could have a role in treating inflammatory diseases. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells.
    Targets: Bcl-2/Bax | Caspase | Akt | Nrf2 | HO-1 | MAPK | NF-κB
    In vitro:
    Evid Based Complement Alternat Med. 2013;2013:690190.
    Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway.[Pubmed: 23935671 ]
    Cardiac hypertrophy is a thickening of the heart muscle that is associated with cardiovascular diseases such as hypertension and myocardial infarction. It occurs initially as an adaptive process against increased workloads and often leads to sudden arrhythmic deaths. Studies suggest that the lethal arrhythmia is attributed to hypertrophy-induced destabilization of cardiac electrical activity, especially the prolongation of the action potential. The reduced activity of Ito is demonstrated to be responsible for the ionic mechanism of prolonged action potential duration and arrhythmogeneity. Isosteviol (STV), a derivative of stevioside, plays a protective role in a variety of stress-induced cardiac diseases.
    Here we report effects of STV on rat ISO-induced hypertrophic cardiomyocytes. STV alleviated ISO-induced hypertrophy of cardiomyocytes by decreasing cell area of hypertrophied cardiomyocytes. STV application prevented the prolongation of action potential which was prominent in hypertrophied cells.
    The decrease and increase of current densities for Ito and ICaL observed in hypertrophied myocytes were both prevented by STV application. In addition, the results of qRT-PCR suggested that the changes of electrophysiological activity of Ito and ICaL are correlated to the alterations of the mRNA transcription level.
    In vivo:
    Food Funct . 2017 Oct 18;8(10):3723-3736.
    Anticancer effects of ginsenoside Rk3 on non-small cell lung cancer cells: in vitro and in vivo[Pubmed: 28949353]
    Abstract Ginsenoside Rk3 (Rk3) is present in the roots of processed Panax notoginseng herbs and it exerts anti-platelet aggregation, pro-immunogenic and cardioprotective effects. However, little is known regarding the anticancer activities of this compound, especially in lung cancer. This study was designed to investigate the anticancer effects of Rk3 on non-small cell lung cancer (NSCLC) cells and in an H460 xenograft tumor model. Our results showed that Rk3 reduced cell viability, inhibited both cell proliferation and colony formation, and induced G1 phase cell cycle arrest by downregulating the expression of cyclin D1 and CDK4 and upregulating the expression of P21. Rk3 also induced apoptosis in a concentration-dependent manner in H460 and A549 cells by Annexin V/PI staining, TUNEL assay and JC-1 staining, resulting in a change in the nuclear morphology. Moreover, Rk3 induced the activation of caspase-8, -9, and -3, promoted changes in mitochondrial membrane potential, decreased the expression of Bcl-2, increased the expression of Bax, and caused the release of cytochrome c, which indicated that the apoptosis-inducing effects of Rk3 were triggered via death receptor-mediated mitochondria-dependent pathways. Furthermore, Rk3 significantly inhibited the growth of H460 xenograft tumors without an obvious effect on the body weight of the treated mice. Histological analysis indicated that Rk3 inhibited tumor growth by altering the proliferation and morphology of tumor cells. In addition, we confirmed that Rk3 inhibited angiogenesis via CD34 staining and chick embryo chorioallantoic membrane (CAM) assay in vivo. Taken together, our findings revealed not only the anticancer effect of Rk3 on NSCLC cells but also a new promising therapeutic agent for human NSCLC.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6106 mL 8.0528 mL 16.1057 mL 32.2113 mL 40.2641 mL
    5 mM 0.3221 mL 1.6106 mL 3.2211 mL 6.4423 mL 8.0528 mL
    10 mM 0.1611 mL 0.8053 mL 1.6106 mL 3.2211 mL 4.0264 mL
    50 mM 0.0322 mL 0.1611 mL 0.3221 mL 0.6442 mL 0.8053 mL
    100 mM 0.0161 mL 0.0805 mL 0.1611 mL 0.3221 mL 0.4026 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 5mg QQ客服:1457312923
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:2159513211
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 5mg QQ客服:1457312923
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:215959384
    达木林A; Damulin A CFN91838 1202868-74-3 C42H70O13 = 783.0 5mg QQ客服:1413575084
    达木林B; Damulin B CFN91837 1202868-75-4 C42H70O13 = 783.0 5mg QQ客服:1457312923
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:2056216494
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 5mg QQ客服:1413575084
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:215959384
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:3257982914





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