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  • 人参皂苷Rg6

    Ginsenoside Rg6

    人参皂苷Rg6
    产品编号 CFN90565
    CAS编号 147419-93-0
    分子式 = 分子量 C42H70O12 = 766.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷Rg6 CFN90565 147419-93-0 1mg QQ客服:2056216494
    人参皂苷Rg6 CFN90565 147419-93-0 5mg QQ客服:2056216494
    人参皂苷Rg6 CFN90565 147419-93-0 10mg QQ客服:2056216494
    人参皂苷Rg6 CFN90565 147419-93-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JEJU National University2022, 24032.
  • Cancers (Basel).2023, 15(1):37.
  • Nutrients.2020, 12(12):3638.
  • Inflammation2015, 38(1):445-55
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  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • BMC Complement Altern Med.2016, 16:213
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  • Molecules.2019, 24(2):329
  • J Ethnopharmacol.2022, 291:115159.
  • Plants (Basel).2023, 12(22):3877.
  • Preprints2022, 202211.0388.v1.
  • Phytomedicine.2020, 79, 153351
  • Pak J Pharm Sci.2018, 31:311-315
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • ...
  • 生物活性
    Description: Ginsenoside Rg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis, the mechanism may through mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression.
    Targets: Bcl-2/Bax
    In vitro:
    Biomol Ther (Seoul) . 2014 Jan;22(1):55-61.
    Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosides from Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells[Pubmed: 24596622]
    Abstract Panax ginseng is a medicinal herb that is used worldwide. Its medicinal effects are primarily attributable to ginsenosides located in the root, leaf, seed, and flower. The flower buds of Panax ginseng (FBPG) are rich in various bioactive ginsenosides, which exert immunomodulatory and anti-inflammatory activities. The aim of the present study was to assess the effect of 18 ginsenosides isolated from steamed FBPG on the transcriptional activity of NF-κB and the expression of tumor necrosis factor-α (TNF-α)-stimulated target genes in liver-derived cell lines. Noticeably, the ginsenosides Rk3 and Rs4 exerted the strongest activity, inhibiting NF-κB in a dose-dependent manner. SF and Rg6 also showed moderately inhibitory effects. Furthermore, these four compounds inhibited the TNF-α-induced expression of IL8, CXCL1, iNOS, and ICAM1 genes. Consequently, ginsenosides purified from steamed FBPG have therapeutic potential in TNF-α-mediated diseases such as chronic hepatic inflammation. Keywords: Hepatocyte derived cells; NF-κB inhibitory activity; Panax ginseng flower buds; Tumor necrosis factor-α.
    Molecules . 2013 Jul 9;18(7):8109-19.
    Apoptosis-inducing effect of ginsenoside Rg6 on human lymphocytoma JK cells[Pubmed: 23839115]
    Abstract In this communication our aim was to study the JK cell growth inhibitory and apoptosis-inducing effects of ginsenoside Rg6 (GRg6) from steamed notoginseng on human lymphocytoma. The CCK-8 method was used to observe the anti-proliferative effect of GRg6 on human lymphocytoma JK cells. Flow cytometry was performed to analyze the influence of GRg6 on cell cycle. The Annexin-V FITC/PI double-staining method was used to detect the ratio of apoptotic cells. JC-1 staining was undertaken to observe the influence of GRg6 on intracellular mitochondrial membrane potential. Finally, western blots were conducted to detect the expression level of apoptosis-related Bax and the Bcl-2 proteins. The results suggested that GRg6 can inhibit the proliferation of human lymphocytoma JK cells. GRg6 blocks an S arrest in the cell cycle. With the increase in GRg6 concentration, the potential in the cell decreased in a dose dependent manner, and Bax protein expression gradually increased, whereas Bcl-2 protein expression gradually decreased. In conclusion, GRg6 can inhibit JK cell proliferation in human lymphocytoma and induce its apoptosis. The mechanism of action may be related to mitochondrial dysfunction and an increase of Bax expression and decrease of Bcl-2 expression caused by GRg6.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3046 mL 6.5232 mL 13.0463 mL 26.0926 mL 32.6158 mL
    5 mM 0.2609 mL 1.3046 mL 2.6093 mL 5.2185 mL 6.5232 mL
    10 mM 0.1305 mL 0.6523 mL 1.3046 mL 2.6093 mL 3.2616 mL
    50 mM 0.0261 mL 0.1305 mL 0.2609 mL 0.5219 mL 0.6523 mL
    100 mM 0.013 mL 0.0652 mL 0.1305 mL 0.2609 mL 0.3262 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rk3; Ginsenoside Rk3 CFN92593 364779-15-7 C36H60O8 = 620.9 10mg QQ客服:2159513211
    人参皂苷Rg6; Ginsenoside Rg6 CFN90565 147419-93-0 C42H70O12 = 766.5 5mg QQ客服:3257982914
    人参皂苷Rh4; Ginsenoside Rh4 CFN92594 174721-08-5 C36H60O8 = 620.9 10mg QQ客服:2056216494
    人参皂苷Rg4; Ginsenoside Rg4 CFN90572 126223-28-7 C42H70O12 = 767.0 5mg QQ客服:1457312923
    3-乙酰氧基-24-羟基达玛-20,25-二烯; 3-Acetoxy-24-hydroxydammara-20,25-diene CFN99477 143519-04-4 C32H52O3 = 484.8 5mg QQ客服:2056216494
    人参皂苷Rk2; Ginsenoside Rk2 CFN92818 364779-14-6 C36H60O7 = 604.9 5mg QQ客服:1457312923
    人参皂苷Rk1; Ginsenoside Rk1 CFN92644 494753-69-4 C42H70O12 = 767.0 20mg QQ客服:1457312923
    人参皂苷Rh3; Ginsenoside Rh3 CFN99972 105558-26-7 C36H60O7 = 604.86 5mg QQ客服:2159513211
    人参皂苷Rg5; Ginsenoside Rg5 CFN92643 186763-78-0 C42H70O12 = 767.0 10mg QQ客服:1413575084
    达木林A; Damulin A CFN91838 1202868-74-3 C42H70O13 = 783.0 5mg QQ客服:215959384

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