灵芝酸Z

Ganoderic acid Z

	产品编号	CFN90295
	CAS编号	294674-09-2
	分子式 = 分子量	C₃₀H₄₂O₇ = 514.66
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruit body of Ganoderma lucidum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
灵芝酸Z	CFN90295	294674-09-2	1mg	QQ客服：2056216494
灵芝酸Z	CFN90295	294674-09-2	5mg	QQ客服：2056216494
灵芝酸Z	CFN90295	294674-09-2	10mg	QQ客服：2056216494
灵芝酸Z	CFN90295	294674-09-2	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universita' Degli Studi Di Cagliari (Italy)

University of Zurich (Switzerland)

University of Pretoria (South Africa)

Melbourne University (Australia)

Florida A&M University (USA)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

Sri Ramachandra University (India)

Agricultural Research Organization (ARO) (Israel)

University of Fribourg (Switzerland)

Universidad de Antioquia (Colombia)

Technical University of Denmark (Denmark)

Universidad de La Salle (Mexico)

Florida International University (USA)

Korea Food Research Institute(KFRI) (Korea)

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Description:

The binding affinities of ganoderic acid DM and ganoderic acid Z (ΔGbind, −16.83 and−10.99 kcal mol−1) are comparable to that of current commercial drug oseltamivir (−23.62 kcal mol−1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Targets:

Antifection

In vitro:

Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1026-33.

Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells.[Pubmed: 10923835]

METHODS AND RESULTS:
Six new highly oxygenated lanostane-type triterpenes, called ganoderic acid gamma (1), ganoderic acid delta (2), ganoderic acid epsilon (3), ganoderic acid zeta (Ganoderic acid Z,4), ganoderic acid eta (5) and ganoderic acid theta (6), were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D (7) and ganoderic acid C2 (8). Their structures of the new triterpenes were determined as (23S)-7beta,15alpha,23-trihydroxy-3,11-dioxolanosta-8, 24(E)-diene-26-oic acid (1), (23S)-7alpha,15alpha23-trihydroxy-3,11-dioxolanosta-8, 24(E)-diene-26-oic acid (2), (23S)-3beta3,7beta, 23-trihydroxy-11,15-dioxolanosta-8,24(E)-diene-26-oic acid (3), (23S)-3beta,23-dihydroxy-7,11,15-trioxolanosta-8, 24(E)-diene-26-oic acid (4), (23S)-3beta,7beta,12beta,23-tetrahydroxy-11,15-dioxolanos ta-8,24(E)-diene-26-oic acid (5) and (23S)-3beta,12beta23-trihydroxy-7,11,15-trioxolanosta-8,24(E )-diene-26-oic acid (6), respectively, by chemical and spectroscopic means, which included the determination of a chiral center in the side chain by a modification of Mosher's method. The cytotoxicity of the compounds isolated from the Ganoderma spores was carried out in vitro against Meth-A and LLC tumor cell lines.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
灵芝酸D甲酯; Methyl ganoderate D	CFN95581	97210-12-3	C₃₁H₄₄O₇ = 528.7	5mg	QQ客服：2159513211
12-羟基灵芝酸D; 12-Hydroxyganoderic acid D	CFN91921	942950-96-1	C₃₀H₄₂O₈ = 530.65	5mg	QQ客服：215959384
12-乙酰氧基灵芝酸D; 12-Acetoxy ganoderic acid D	CFN95535	N/A	C₃₂H₄₄O₉ = 572.7	5mg	QQ客服：2056216494
12β-灵芝酸M; Ganoderic acid M	CFN90747	100761-17-9	C₃₀H₄₂O₈ = 530.7	10mg	QQ客服：1413575084
灵芝酸Z; Ganoderic acid Z	CFN90295	294674-09-2	C₃₀H₄₂O₇ = 514.66	5mg	QQ客服：215959384
灵芝酸AM1; Ganoderic acid AM1	CFN90296	149507-55-1	C₃₀H₄₂O₇ = 514.66	5mg	QQ客服：3257982914
Ethyl ganoderate J; Ethyl ganoderate J	CFN92576	1189555-95-0	C₃₂H₄₆O₇ = 542.7	5mg	QQ客服：1413575084
灵芝酸E甲酯; Methyl ganoderate E	CFN95582	98718-43-5	C₃₁H₄₂O₇ = 526.7	5mg	QQ客服：3257982914
Hainanic acid B; Hainanic acid B	CFN95526	1637737-46-2	C₃₀H₄₂O₇ = 514.7	5mg	QQ客服：215959384
新化合物18; New compound 18	CFN95527	N/A	C₃₀H₄₄O₇ = 516.7	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.943 mL	9.7152 mL	19.4303 mL	38.8606 mL	48.5758 mL
5 mM	0.3886 mL	1.943 mL	3.8861 mL	7.7721 mL	9.7152 mL
10 mM	0.1943 mL	0.9715 mL	1.943 mL	3.8861 mL	4.8576 mL
50 mM	0.0389 mL	0.1943 mL	0.3886 mL	0.7772 mL	0.9715 mL
100 mM	0.0194 mL	0.0972 mL	0.1943 mL	0.3886 mL	0.4858 mL