补骨脂香豆素A
Ficusin A
|
|
产品编号 |
CFN99817 |
| CAS编号 |
173429-83-9 |
| 分子式 = 分子量 |
C25H24O5 = 404.5 |
| 产品纯度 |
>=98% |
| 物理属性 |
Yellow powder |
| 化合物类型 |
Flavonoids |
| 植物来源 |
The seeds of Psoralea corylifolia Linn. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 补骨脂香豆素A |
CFN99817 |
173429-83-9 |
1mg |
QQ客服：2159513211 |
| 补骨脂香豆素A |
CFN99817 |
173429-83-9 |
5mg |
QQ客服：2159513211 |
| 补骨脂香豆素A |
CFN99817 |
173429-83-9 |
10mg |
QQ客服：2159513211 |
| 补骨脂香豆素A |
CFN99817 |
173429-83-9 |
20mg |
QQ客服：2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPARγ expression and improve the translocation and activation of GLUT4 in the adipose tissue, suggests that ficusin improves the insulin sensitivity on adipose tissue and it can be used for the treatment of obesity related type 2 diabetes mellitusl. |
| Targets: |
GLUT | PPAR |
| In vivo: |
| Chem. Biol. Interact.,2016,256:85-93. | | Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats.[Reference: WebLink] | In this study, the antioxidant, antilipidemic and antidiabetic effects of ficusin isolated from Ficus carica leaves and their effects on GLUT4 translocation and PPARγ expression were evaluated in HFD-STZ induced type 2 diabetic rats.
METHODS AND RESULTS:
Ficusin (20 and 40 mg/kg b. wt.) lowered the levels of fasting blood glucose, plasma insulin and body weight gain, in HFD-STZ induced diabetic rats. Ficusin Also significantly lowered the serum antioxidant enzymes (SOD, CAT and GPx) and lipids (TC, TG and FFA) levels to near normal. Ficusin significantly enhanced the PPARγ expression and improved the translocation and activation of GLUT4 in the adipose tissue. Molecular docking analysis exhibited promising interactions of GLUT4 and PPARγ into their active sites.
CONCLUSIONS:
This study suggests that ficusin improved the insulin sensitivity on adipose tissue and it can be used for the treatment of obesity related type 2 diabetes mellitus. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.4722 mL |
12.3609 mL |
24.7219 mL |
49.4438 mL |
61.8047 mL |
| 5 mM |
0.4944 mL |
2.4722 mL |
4.9444 mL |
9.8888 mL |
12.3609 mL |
| 10 mM |
0.2472 mL |
1.2361 mL |
2.4722 mL |
4.9444 mL |
6.1805 mL |
| 50 mM |
0.0494 mL |
0.2472 mL |
0.4944 mL |
0.9889 mL |
1.2361 mL |
| 100 mM |
0.0247 mL |
0.1236 mL |
0.2472 mL |
0.4944 mL |
0.618 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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