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  • 杜鹃素

    Farrerol

    杜鹃素
    产品编号 CFN90337
    CAS编号 24211-30-1
    分子式 = 分子量 C17H16O5 = 300.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The leaves of Rhododendron dauricum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    杜鹃素 CFN90337 24211-30-1 10mg QQ客服:2056216494
    杜鹃素 CFN90337 24211-30-1 20mg QQ客服:2056216494
    杜鹃素 CFN90337 24211-30-1 50mg QQ客服:2056216494
    杜鹃素 CFN90337 24211-30-1 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • National Cancer Institute (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Indian Institute of Science (India)
  • Florida A&M University (USA)
  • Almansora University (Egypt)
  • Hamdard University (India)
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  • National Cancer Center Research Institute (Japan)
  • St. Jude Children Research Hospital (USA)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Michigan State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceutics.2021, 13(11):1839.
  • Planta Med.2023, a-2192-2281.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Molecules.2021, 26(12):3652.
  • South African J of Plant&Soil2018, 29-32
  • Fitoterapia.2022, 105141.
  • J Complement Integr Med.2024, jcim-2023-0177.
  • Phytochem Anal.2024, pca.3319.
  • Materials Today Communications2023, 37:107216
  • Plants (Basel).2023, 12(22):3877.
  • Journal of Plant Growth Regulation2022, 10705-2.
  • Viruses2023, 15(6), 1377
  • Toxins (Basel).2020, 12(4):210.
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Int J Mol Sci.2021, 22(11):5503.
  • Am J Chin Med.2015, 30:1-22
  • Phytother Res.2018, 32(12):2551-2559
  • Front. Physiol.2022, 790345.
  • Phytomedicine Plus2022, 2(1):100207.
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Journal of Functional Foods2022, 99: 105331.
  • ...
  • 生物活性
    Description: Farrerol has antioxidative, anti-bacterial, anti-inflammatory, antiangiogenic activities, it is a potential candidate for the intervention of endothelial-injury-associated cardiovascular diseases. Farrerol inactivates KEAP-1 or activates the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduces the intracellular production of reactive oxygen species via the induction of HO-1 expression. Farrerol can inhibit angiogenesis through down regulation of Akt/mTOR, Erk and Jak2/Stat3 signal pathway, and can inhibit IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-κB signaling pathway.
    Targets: HO-1 | ROS | Akt | p38MAPK | JNK | ERK | Nrf2 | Bcl-2/Bax | Caspase | NO | NF-kB | SOD | PGE | IL Receptor | PI3K | mTOR | JAK | STAT
    In vitro:
    Chem Biol Interact. 2015 Jun 22.
    The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells.[Pubmed: 26111761]
    Farrerol, (S)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone, isolated from rhododendron, has been shown to have antioxidative potential, but the molecular mechanism underlying this activity remains unclear. The inducible expression of heme oxygenase-1 (HO-1), a potent antioxidative and cytoprotective enzyme, is known to play an important role in cytoprotection in a variety of pathological models.
    METHODS AND RESULTS:
    In this study, we evaluated the antioxidative potential of farrerol against oxidative damage and investigated its antioxidative mechanism in RAW 264.7 cells. The molecular mechanism underlying the cytoprotective function of farrerol was determined by analyzing intracellular signaling pathways, transcriptional activation and the inhibitory effect of HO-1 on ROS production. Farrerol induced antioxidant enzymes mRNA expression, HO-1 protein expression and nuclear translocation of NF-E2-related factor 2 in RAW 264.7 macrophage cells. Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression. Further investigation utilizing Western blotting and specific inhibitors of Akt, p38, JNK and ERK demonstrated that Akt, p38, and ERK axis of signaling pathway mediates HO-1 expression. Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp). It is hence likely that farrerol inactivated KEAP-1 or activated the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduced the intracellular production of reactive oxygen species via the induction of HO-1 expression.
    CONCLUSIONS:
    These results support the central role of HO-1 in the cytoprotective effect of farrerol.
    Microb Pathog. 2013 Dec;65:1-6.
    Farrerol regulates antimicrobial peptide expression and reduces Staphylococcus aureus internalization into bovine mammary epithelial cells.[Pubmed: 24036182]
    Mastitis, defined as inflammation of the mammary gland, is an infectious disease with a major economic influence on dairy industry. Staphylococcus aureus is a common gram-positive pathogen that frequently causes subclinical, chronic infection of the mammary gland in dairy cows. Farrerol, a traditional Chinese medicine isolated from rhododendron, has been shown to have anti-bacterial activity. However, the effect of farrerol on S. aureus infection in mammary epithelium has not been studied in detail. The aim of this study was to investigate the effect of farrerol on the invasion of bovine mammary epithelial cells (bMEC) by S. aureus.
    METHODS AND RESULTS:
    The expression of antimicrobial peptide genes by bMEC were assessed in the presence or absence of S. aureus infection. Our results demonstrated that farrerol (4-16 μg/ml) reduced > 55% the internalization of S. aureus into bMEC. We also found that farrerol was able to down-regulate the mRNA expression of tracheal antimicrobial peptide (TAP) and bovine neutrophil β-defensin 5 (BNBD5) in bMEC infected with S. aureus. The Nitric oxide (NO) production of bMEC after S. aureus stimulation was decreased by farrerol treatment. Furthermore, farrerol treatment suppressed S. aureus-induced NF-κB activation in bMEC.
    CONCLUSIONS:
    These results demonstrated that farrerol modulated TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection and could be useful in protection against bovine mastitis.
    Eur J Pharmacol. 2015 Oct 5;764:443-7.
    Anti-inflammatory effects of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes.[Pubmed: 26162701 ]
    The present study aimed to investigate the anti-inflammatory effects and the underlying molecular mechanism of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes.
    METHODS AND RESULTS:
    Chondrocytes were pretreated with farrerol 1h before IL-1β stimulation. The effects of farrerol on NO and PGE2 production were tested by Griess reagent and ELISA. The effects of farrerol on COX-2, iNOS, Akt, phosphorylated Akt, and NF-κB activation were measured by western blot analysis. The results showed that farrerol remarkably inhibited IL-1β-induced NO and PGE2 production, as well as COX-2 and iNOS expression. Farrerol also inhibited IL-1β-induced NF-κB activation. Furthermore, farrerol significantly inhibited IL-1β-induced phosphorylation of PI3K and Akt.
    CONCLUSIONS:
    In conclusion, these results indicated that farrerol inhibited IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-κB signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7,4'-三羟基-8-甲基二氢黄酮; 5,7,4'-Trihydroxy-8-methylflavanone CFN90711 916917-28-7 C16H14O5 = 286.08 5mg QQ客服:1413575084
    去甲杜鹃素; Poriol CFN96502 14348-16-4 C16H14O5 = 286.28 10mg QQ客服:2159513211
    5,4’-二羟基-6-甲基-7-甲氧基黄烷酮; 7-O-Methylporiol CFN96038 206560-99-8 C17H16O5 = 300.3 5mg QQ客服:3257982914
    杜鹃素; Farrerol CFN90337 24211-30-1 C17H16O5 = 300.3 20mg QQ客服:3257982914
    Angophorol; Angophorol CFN96057 133442-54-3 C18H18O5 = 314.3 5mg QQ客服:3257982914
    6-Methyl-8-prenylnaringenin; 6-Methyl-8-prenylnaringenin CFN96548 261776-60-7 C21H22O5 = 354.40 5mg QQ客服:1457312923

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