| In vitro: |
| Planta Medica, 2013,79 (5):55. | | Therapeutic Efficacy of Phenolic Compounds from Micnia prasina. in Acute Lymphoblastic Leukemia.[Reference: WebLink] |
METHODS AND RESULTS:
Three flavonones A, B, and C, were isolated from the leaves and stem of Miconia prasina. The flavonones were characterized structurally as (-)-farrerol (A), Angophorol (B) and desmethoxymatteucinol (C), respectively. Their structures were elucidated by spectroscopic analysis including HRMS, 1D, and 2D NMR. The anti-leukemia effect of the flavonones constituents of the Miconia prasina leaves was also examined in vitro, where the result showed that flavonones A, B and C exert potential anticancer activity through growth inhibition and apoptosis in K562 cells.
CONCLUSIONS:
This is the first report for these compounds being isolated from Miconia prasina, and it is the first time to measure their anti-leukemia activity against two human leukemia cell lines, HL60 and K562, after a 48h exposure. |
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