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  • 野马追内酯A

    Eupalinolide A

    野马追内酯A
    产品编号 CFN90381
    CAS编号 877822-41-8
    分子式 = 分子量 C24H30O9 = 462.49
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Eupatorium lindleyanum DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    野马追内酯A CFN90381 877822-41-8 10mg QQ客服:215959384
    野马追内酯A CFN90381 877822-41-8 20mg QQ客服:215959384
    野马追内酯A CFN90381 877822-41-8 50mg QQ客服:215959384
    野马追内酯A CFN90381 877822-41-8 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Helsinki (Finland)
  • Mahidol University (Thailand)
  • Medical University of Gdansk (Poland)
  • Universidad de La Salle (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Med Food.2019, 22(10):1067-1077
  • Food and Fermentation Industries2018, 44(371)
  • Front Pharmacol.2021, 12:690113.
  • Journal of Functional Foods2021, 84:104581
  • Biomed Pharmacother.2019, 111:262-269
  • Toxins (Basel).2021, 13(9):593.
  • Molecules.2020, 25(23):5556.
  • Molecules.2023, 28(3):958.
  • Biorxiv2019, 10.1101
  • Molecules.2019, 24(23):E4303
  • Phytother Res.2022, 10.1002:ptr.7602.
  • Int J Mol Sci.2022, 23(1):538.
  • Journal of Functional Foods2022, 96: 105216.
  • J Food Sci.2022, 87(11):4905-4916.
  • J Nat Med.2017, 71(4):745-756
  • Nutrients.2020, 12(12):3607.
  • Nat Prod Sci.2014, 20(3):182-190
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Molecules.2023, 28(19):6775.
  • Scientific World Journal.2014, 2014:654193
  • Vietnam Journal of Science2022,64(2):69-75.
  • iScience.2020, 23(2):100849.
  • Molecules.2019, 24(1):E159
  • ...
  • 生物活性
    Description: Eupalinolide A and Eupalinolide B induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. They could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.
    Targets: HSP (e.g. HSP90)
    In vitro:
    Biochem Pharmacol. 2012 Apr 1;83(7):909-22.
    Purification and characterization of HSP-inducers from Eupatorium lindleyanum.[Pubmed: 22245466]
    The expression of heat shock proteins (HSPs), particularly HSP70, provides resistance to stressors. We recently reported that ultraviolet (UV)-induced melanin production and skin damage were suppressed in transgenic mice expressing HSP70 and that an extract of Eupatorium lindleyanum induces the expression of HSP70 in cells.
    METHODS AND RESULTS:
    Here we report the purification of Eupalinolide A and B (EA and EB) from E. lindleyanum, and describe their actions as HSP-inducers. Eupalinolide A and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability. Treatment of cells with Eupalinolide A or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the Eupalinolide A - or EB-mediated induction of HSP70 expression. Furthermore, EB inhibited the interaction between HSF1 and HSP90, which is known to inhibit the activity of HSF1. These findings suggest that Eupalinolide A and EB induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90. Eupalinolide A and EB both induced the expression of HSP70 synergistically with other stressors. Furthermore, pre-treatment of cells with Eupalinolide A or EB suppressed melanin production and stressor-induced apoptosis. These effects were suppressed by the artificial suppression of HSP70 expression. In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin.
    CONCLUSIONS:
    These results suggest that Eupalinolide A and EB could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.
    In vivo:
    J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 16;995-996C:1-7.
    Pharmacokinetics of eupalinolide A, eupalinolide B and hyperoside from Eupatorium lindleyanum in rats by LC/MS/MS.[Pubmed: 26011510]
    A simple, selective, and sensitive LC/MS/MS method was developed and validated for simultaneous determination of Eupalinolide A, eupalinolide B, and hyperoside in rat plasma. Plasma samples were processed by protein precipitation with acetonitrile.
    METHODS AND RESULTS:
    The three analytes, together with internal standard (IS, lysionotin), were separated on a Venusil MP-C18 column (50mm×2.1mm, 3μm) using a mobile phase of methanol and 10mM ammonium acetate (45:55, v/v) with isocratic elution. Mass spectrometric detection was performed by multiple-reaction monitoring mode via electrospray ionization source. Linear calibration curves were obtained for the following concentration range: 1.28-640ng/mL for Eupalinolide A; 1.98-990ng/mL for EB; and 2.00-1000ng/mL for HYP. The intra- and inter-day precision was less than 10.25%, and the accuracy was between 89.16% and 110.63%. The extraction recovery of the analytes and IS from rat plasma was above 88.75%.
    CONCLUSIONS:
    The validated method has been successfully applied to pharmacokinetic studies of the three analytes following intragastric administration of Eupatorium lindleyanum extract at a single dose of 100, 250, and 625mg/kg to Sprague-Dawley rats, respectively. The pharmacokinetic results may help to better understand the pharmacological actions of the herb E. lindleyanum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1622 mL 10.811 mL 21.6221 mL 43.2442 mL 54.0552 mL
    5 mM 0.4324 mL 2.1622 mL 4.3244 mL 8.6488 mL 10.811 mL
    10 mM 0.2162 mL 1.0811 mL 2.1622 mL 4.3244 mL 5.4055 mL
    50 mM 0.0432 mL 0.2162 mL 0.4324 mL 0.8649 mL 1.0811 mL
    100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.4324 mL 0.5406 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Carabrolactone A; Carabrolactone A CFN99286 1187925-30-9 C15H22O5 = 282.3 5mg QQ客服:2159513211
    11(13)-去氢腋生依瓦菊素; 11(13)-Dehydroivaxillin CFN97438 87441-73-4 C15H20O4 = 264.3 5mg QQ客服:2056216494
    Aeruginolactone; Aeruginolactone CFN92791 1005208-88-7 C15H20O3 = 248.3 5mg QQ客服:2159513211
    野马追内酯O; Eupalinolide O CFN91839 2170228-67-6 C22H26O8 = 418.4 5mg QQ客服:3257982914
    野马追内酯A; Eupalinolide A CFN90381 877822-41-8 C24H30O9 = 462.49 20mg QQ客服:2159513211
    野马追内酯B; Eupalinolide B CFN90382 877822-40-7 C24H30O9 = 462.49 20mg QQ客服:2159513211
    野马追内酯K; Eupalinolide K CFN99435 108657-10-9 C20H26O6 = 362.4 10mg QQ客服:1413575084
    4,15-Isoatriplicolide methylacrylate; 4,15-Isoatriplicolide methylacrylate CFN92956 133559-38-3 C19H20O6 = 344.36 5mg QQ客服:215959384
    Isoatriplicolide tiglate; Isoatriplicolide tiglate CFN92955 133559-39-4 C20H22O6 = 358.39 5mg QQ客服:2056216494

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